pygl phosphorylase, glycogen, liver [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pyglprovided by ZNC
Official Full Name: phosphorylase, glycogen, liverprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041205-1
See related: AllianceGenome:ZFIN:ZDB-GENE-041205-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66314
Summary: Predicted to enable glycogen phosphorylase activity and pyridoxal phosphate binding activity. Predicted to be involved in glycogen catabolic process. Predicted to act upstream of or within glycogen metabolic process. Predicted to be active in cytoplasm. Is expressed in eye; heart; kidney; liver; and muscle. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease VI; and lactic acidosis. Orthologous to human PYGL (glycogen phosphorylase L). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (36846767..36863039, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (36720935..36737207, complement)
103	previous assembly	Zv9 (GCF_000002035.4)	13	NC_007124.5 (37248633..37264905, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation.
Title: The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation.

Submit: New GeneRIF Correction

General gene information

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Homology

Orthologs from Annotation Pipeline: 474 organisms have orthologs with human gene pygl
Orthologs

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 1,4-alpha-oligoglucan phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables SHG alpha-glucan phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables glycogen phosphorylase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables glycogen phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables linear malto-oligosaccharide phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within glycogen metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: glycogen phosphorylase, liver form

Names: phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)

NP_001008538.1

EC 2.4.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008538.1 → NP_001008538.1 glycogen phosphorylase, liver form

See identical proteins and their annotated locations for NP_001008538.1

Status: PROVISIONAL

Source sequence(s)

BC085616

UniProtKB/TrEMBL

Q5RKM9

Conserved Domains (2) summary

cd04300
Location:29 → 940

GT1_Glycogen_Phosphorylase; This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of ...

TIGR02093
Location:32 → 940

P_ylase; glycogen/starch/alpha-glucan phosphorylases