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pygl phosphorylase, glycogen, liver [ Danio rerio (zebrafish) ]

Gene ID: 493916, updated on 5-Jul-2025
Official Symbol
pyglprovided by ZNC
Official Full Name
phosphorylase, glycogen, liverprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041205-1
See related
Ensembl:ENSDARG00000002197 AllianceGenome:ZFIN:ZDB-GENE-041205-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:66314
Summary
Predicted to enable glycogen phosphorylase activity and pyridoxal phosphate binding activity. Predicted to be involved in glycogen catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be active in cytoplasm. Is expressed in eye; heart; kidney; liver; and muscle. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease VI; and lactic acidosis. Orthologous to human PYGL (glycogen phosphorylase L). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See pygl in Genome Data Viewer
Location:
chromosome: 13
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 13 NC_133188.1 (40313650..40330782, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 13 NC_007124.7 (36846767..36863047, complement)

Chromosome 13 - NC_133188.1Genomic Context describing neighboring genes Neighboring gene salvador family WW domain containing protein 1 Neighboring gene ninein (GSK3B interacting protein) Neighboring gene tripartite motif containing 9 Neighboring gene thioredoxin-related transmembrane protein 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation. Martínez-Navarro FJ, et al. Dev Comp Immunol, 2020 Jul. PMID 32126244
  2. gys1 regulates maternal glycogen reserve essential for embryonic development in zebrafish. Chen J, et al. Heliyon, 2024 May 30. PMID 38803914, Free PMC Article
  3. Corosolic acid isolated from Eriobotrya japonica leaves reduces glucose level in human hepatocellular carcinoma cells, zebrafish and rats. Xu S, et al. Sci Rep, 2019 Mar 13. PMID 30867526, Free PMC Article
  4. Glucose metabolism and gene expression in juvenile zebrafish (Danio rerio) challenged with a high carbohydrate diet: effects of an acute glucose stimulus during late embryonic life. Rocha F, et al. Br J Nutr, 2015 Feb 14. PMID 25609020
  5. Glucose overload in yolk has little effect on the long-term modulation of carbohydrate metabolic genes in zebrafish (Danio rerio). Rocha F, et al. J Exp Biol, 2014 Apr 1. PMID 24363414

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation.
    Title: The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1,4-alpha-oligoglucan phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glycogen phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycogen phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
glycogen phosphorylase, liver form
Names
phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)
NP_001410619.1
XP_073775635.1
XP_073775636.1
XP_073775637.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001423690.1 → NP_001410619.1  glycogen phosphorylase, liver form

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000013
    UniProtKB/TrEMBL
    A0AB13A8T7
    Related
    ENSDARP00000123720.1, ENSDART00000149011.2

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133188.1 Reference GRCz12tu Primary Assembly

    Range
    40313650..40330782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073919534.1 → XP_073775635.1  glycogen phosphorylase, liver form isoform X1

    UniProtKB/TrEMBL
    A0AB13A8T7

  2. XM_073919536.1 → XP_073775637.1  glycogen phosphorylase, liver form isoform X1

    UniProtKB/TrEMBL
    A0AB13A8T7

  3. XM_073919535.1 → XP_073775636.1  glycogen phosphorylase, liver form isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001008538.1: Suppressed sequence

    Description
    NM_001008538.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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