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PHOSPHO2 phosphatase, orphan 2 [ Homo sapiens (human) ]

Gene ID: 493911, updated on 23-Nov-2021

Summary

Official Symbol
PHOSPHO2provided by HGNC
Official Full Name
phosphatase, orphan 2provided by HGNC
Primary source
HGNC:HGNC:28316
See related
Ensembl:ENSG00000144362
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 6.7), prostate (RPKM 5.4) and 25 other tissues See more
Orthologs
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Genomic context

See PHOSPHO2 in Genome Data Viewer
Location:
2q31.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (169694469..169701708)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170550979..170558218)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase G Neighboring gene cilia and flagella associated protein 210 Neighboring gene CYFIP related Rac1 interactor B pseudogene Neighboring gene PHOSPHO2-KLHL23 readthrough Neighboring gene kelch like family member 23 Neighboring gene thioredoxin 1 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Readthrough PHOSPHO2-KLHL23

Readthrough gene: PHOSPHO2-KLHL23, Included gene: KLHL23

Homology

Clone Names

  • MGC22679, MGC111048

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables pyridoxal phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pyridoxal phosphate phosphatase PHOSPHO2
NP_001008489.1
NP_001186214.1
NP_001186215.1
NP_001186216.1
NP_001186217.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008489.4NP_001008489.1  pyridoxal phosphate phosphatase PHOSPHO2

    See identical proteins and their annotated locations for NP_001008489.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein.
    Source sequence(s)
    BC106013
    Consensus CDS
    CCDS33319.1
    UniProtKB/Swiss-Prot
    Q8TCD6
    Related
    ENSP00000352782.3, ENST00000359744.8
    Conserved Domains (1) summary
    pfam06888
    Location:3239
    Put_Phosphatase; Putative Phosphatase
  2. NM_001199285.2NP_001186214.1  pyridoxal phosphate phosphatase PHOSPHO2

    See identical proteins and their annotated locations for NP_001186214.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein.
    Source sequence(s)
    AK314915, BC106013
    Consensus CDS
    CCDS33319.1
    UniProtKB/Swiss-Prot
    Q8TCD6
    Conserved Domains (1) summary
    pfam06888
    Location:3239
    Put_Phosphatase; Putative Phosphatase
  3. NM_001199286.2NP_001186215.1  pyridoxal phosphate phosphatase PHOSPHO2

    See identical proteins and their annotated locations for NP_001186215.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants (1-5) encode the same protein.
    Source sequence(s)
    BC106013, BI550291, DA211528
    Consensus CDS
    CCDS33319.1
    UniProtKB/Swiss-Prot
    Q8TCD6
    Related
    ENSP00000481046.1, ENST00000616524.4
    Conserved Domains (1) summary
    pfam06888
    Location:3239
    Put_Phosphatase; Putative Phosphatase
  4. NM_001199287.2NP_001186216.1  pyridoxal phosphate phosphatase PHOSPHO2

    See identical proteins and their annotated locations for NP_001186216.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein.
    Source sequence(s)
    BC106013, BM820383, DA211528
    Consensus CDS
    CCDS33319.1
    UniProtKB/Swiss-Prot
    Q8TCD6
    Related
    ENSP00000481680.1, ENST00000616481.4
    Conserved Domains (1) summary
    pfam06888
    Location:3239
    Put_Phosphatase; Putative Phosphatase
  5. NM_001199288.2NP_001186217.1  pyridoxal phosphate phosphatase PHOSPHO2

    See identical proteins and their annotated locations for NP_001186217.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein.
    Source sequence(s)
    BC106013, DA211528, DB443540
    Consensus CDS
    CCDS33319.1
    UniProtKB/Swiss-Prot
    Q8TCD6
    Related
    ENSP00000481857.1, ENST00000617738.4
    Conserved Domains (1) summary
    pfam06888
    Location:3239
    Put_Phosphatase; Putative Phosphatase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    169694469..169701708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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