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RNASE12 ribonuclease A family member 12 (inactive) [ Homo sapiens (human) ]

Gene ID: 493901, updated on 7-Jul-2022

Summary

Official Symbol
RNASE12provided by HGNC
Official Full Name
ribonuclease A family member 12 (inactive)provided by HGNC
Primary source
HGNC:HGNC:24211
See related
Ensembl:ENSG00000258436 AllianceGenome:HGNC:24211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAI1; HEL-S-85p
Summary
Predicted to enable nucleic acid binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See RNASE12 in Genome Data Viewer
Location:
14q11.2
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (20590073..20591376, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (14787199..14788502, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21058232..21059535, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene SET pseudogene 1 Neighboring gene ribonuclease A family member 9 (inactive) Neighboring gene ribonuclease A family member 11 (inactive) Neighboring gene RNASE11 and RNASE12 antisense RNA 1 Neighboring gene uncharacterized LOC124903280 Neighboring gene tRNA-Pro (anticodon AGG) 2-5 Neighboring gene tRNA-Leu (anticodon AAG) 2-3

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT enables ribonuclease activity IKR
Inferred from Key Residues
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable inactive ribonuclease-like protein 12
Names
epididymis secretory sperm binding protein Li 85p
ribonuclease A I1
ribonuclease, RNase A family, 12 (non-active)
ribonuclease-like protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024822.4NP_001019993.1  probable inactive ribonuclease-like protein 12 precursor

    See identical proteins and their annotated locations for NP_001019993.1

    Status: VALIDATED

    Source sequence(s)
    AL163195
    Consensus CDS
    CCDS32037.1
    UniProtKB/Swiss-Prot
    Q5GAN4
    UniProtKB/TrEMBL
    W0UV30
    Related
    ENSP00000512867.1, ENST00000696784.1
    Conserved Domains (1) summary
    cd00163
    Location:24143
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    20590073..20591376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    14787199..14788502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)