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OAS2 2'-5'-oligoadenylate synthetase 2 [ Homo sapiens (human) ]

Gene ID: 4939, updated on 3-Jun-2018
Official Symbol
OAS2provided by HGNC
Official Full Name
2'-5'-oligoadenylate synthetase 2provided by HGNC
Primary source
HGNC:HGNC:8087
See related
Ensembl:ENSG00000111335 MIM:603350; Vega:OTTHUMG00000169802
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 18.2), lymph node (RPKM 14.1) and 22 other tissues See more
Orthologs
See OAS2 in Genome Data Viewer
Location:
12q24.13
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (112978466..113011723)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (113416274..113449528)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene 2'-5'-oligoadenylate synthetase 1 Neighboring gene 2'-5'-oligoadenylate synthetase 3 Neighboring gene inner mitochondrial membrane peptidase subunit 1 pseudogene 2 Neighboring gene ribosomal protein S15a pseudogene 32

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 and the viral protein Tat modulate the expression of 2',5'-oligoadenylate synthetase 2, 69/71kDa (OAS2) in immature dendritic cells and monocyte-derived macrophages PubMed
tat HIV-1 Tat interacts with interferon-inducible enzymes 2-5A synthetase and dsRNA-dependent protein kinase to influence the rate of translation and protein synthesis in vitro PubMed
Vpr vpr HIV-1 Vpr upregulates the gene expression of OAS2 in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Hepatitis C, organism-specific biosystem (from KEGG)
    Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hepatitis C, conserved biosystem (from KEGG)
    Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
    Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...
  • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
    Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC78578

Gene Ontology Provided by GOA

Function Evidence Code Pubs
2'-5'-oligoadenylate synthetase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
2'-5'-oligoadenylate synthetase activity IDA
Inferred from Direct Assay
more info
PubMed 
2'-5'-oligoadenylate synthetase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ATP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA catabolic process IEA
Inferred from Electronic Annotation
more info
 
defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
regulation of lactation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to virus TAS
Traceable Author Statement
more info
PubMed 
type I interferon signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
2'-5'-oligoadenylate synthase 2
Names
(2'-5')oligo(A) synthetase 2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
2-5A synthase 2
p69 OAS / p71 OAS
NP_001027903.1
NP_002526.2
NP_058197.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029692.1 RefSeqGene

    Range
    5001..38255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032731.1NP_001027903.1  2'-5'-oligoadenylate synthase 2 isoform 3

    See identical proteins and their annotated locations for NP_001027903.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an additional segment in the 5' coding region, compared to variant 1, which leads to a premature stop codon. It encodes isoform 3, which has a shorter, distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC004551, BC069052, BE885222
    Consensus CDS
    CCDS44982.1
    UniProtKB/Swiss-Prot
    P29728
    UniProtKB/TrEMBL
    Q7Z6D0
    Related
    ENSP00000411763.2, OTTHUMP00000242133, ENST00000449768.2, OTTHUMT00000405946
    Conserved Domains (1) summary
    cd05400
    Location:31150
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
  2. NM_002535.2NP_002526.2  2'-5'-oligoadenylate synthase 2 isoform 2

    See identical proteins and their annotated locations for NP_002526.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional segment in the 3' coding region, compared to variant 1, which leads to a premature stop codon. It encodes isoform 2, also known as p69, which has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC004551, BC049215, BE885222, BQ213828
    Consensus CDS
    CCDS41839.1
    UniProtKB/Swiss-Prot
    P29728
    Related
    ENSP00000376362.2, OTTHUMP00000242132, ENST00000392583.6, OTTHUMT00000405945
    Conserved Domains (2) summary
    cd05400
    Location:362545
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:498685
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
  3. NM_016817.2NP_058197.2  2'-5'-oligoadenylate synthase 2 isoform 1

    See identical proteins and their annotated locations for NP_058197.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1), which is also known as the p71 isoform.
    Source sequence(s)
    AC004551, BC049215, BE885222, BQ213828
    Consensus CDS
    CCDS31906.1
    UniProtKB/Swiss-Prot
    P29728
    Related
    ENSP00000342278.4, OTTHUMP00000242125, ENST00000342315.8, OTTHUMT00000405937
    Conserved Domains (2) summary
    cd05400
    Location:362545
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:496683
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    112978466..113011723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001748725.2 RNA Sequence

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