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GPX8 glutathione peroxidase 8 (putative) [ Homo sapiens (human) ]

Gene ID: 493869, updated on 12-Oct-2019

Summary

Official Symbol
GPX8provided by HGNC
Official Full Name
glutathione peroxidase 8 (putative)provided by HGNC
Primary source
HGNC:HGNC:33100
See related
Ensembl:ENSG00000164294 MIM:617172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPx-8; UNQ847; EPLA847; GSHPx-8
Expression
Broad expression in placenta (RPKM 14.8), endometrium (RPKM 12.4) and 20 other tissues See more
Orthologs

Genomic context

See GPX8 in Genome Data Viewer
Location:
5q11.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (55160155..55167297)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (54455984..54463129)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene granzyme A pseudogene 1 Neighboring gene granzyme A Neighboring gene cell division cycle 20B Neighboring gene microRNA 449a Neighboring gene microRNA 449b

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity EXP
Inferred from Experiment
more info
PubMed 
peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable glutathione peroxidase 8
NP_001008398.2
NP_001293126.1
NP_001293127.1
NP_001293130.1
XP_006714694.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008397.4NP_001008398.2  probable glutathione peroxidase 8 isoform a

    See identical proteins and their annotated locations for NP_001008398.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK074216, BM988796, BX537894, BX647770, CN390753
    Consensus CDS
    CCDS34156.1
    UniProtKB/Swiss-Prot
    Q8TED1
    Related
    ENSP00000423822.1, ENST00000503787.6
    Conserved Domains (1) summary
    TIGR02540
    Location:46198
    gpx7; putative glutathione peroxidase Gpx7
  2. NM_001306197.2NP_001293126.1  probable glutathione peroxidase 8 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' terminal exon, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK298545, BM988796, BX537894, BX647770, CN390753
    Consensus CDS
    CCDS78009.1
    UniProtKB/Swiss-Prot
    Q8TED1
    UniProtKB/TrEMBL
    B4DPY0, E7ETY7
    Related
    ENSP00000427466.1, ENST00000515370.1
    Conserved Domains (1) summary
    cl00388
    Location:15147
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  3. NM_001306198.2NP_001293127.1  probable glutathione peroxidase 8 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon, resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK074216, AK307365, BM988796, BX537894, BX647770, CN390753
    Consensus CDS
    CCDS82997.1
    UniProtKB/Swiss-Prot
    Q8TED1
    UniProtKB/TrEMBL
    J3KNB5
    Related
    ENSP00000296734.6, ENST00000296734.6
    Conserved Domains (1) summary
    cl00388
    Location:4669
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  4. NM_001306201.2NP_001293130.1  probable glutathione peroxidase 8 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in both the 5' terminal exon and in an internal exon, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.
    Source sequence(s)
    AK074216, BM988796, BX537894, BX647770, CN390753, DA660205
    UniProtKB/Swiss-Prot
    Q8TED1
    Conserved Domains (1) summary
    cl00388
    Location:14105
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RNA

  1. NR_131336.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) splices out an alternate segment in the 5' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BM988796, BX537894, BX647770, CN390753
    Related
    ENST00000506123.5
  2. NR_131337.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) splices out an alternate segment in the 5' terminal exon, and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BM835879, BM988796, BX537894, BX647770, CN390753
  3. NR_131338.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) splices out an alternate segment in the 5' terminal exon, and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK074216, BM988796, BX537894, BX647770, CN390753, HY174481
  4. NR_131340.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK074216, BG620710, BM988796, BX537894, BX647770, CN390753

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    55160155..55167297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714631.2XP_006714694.1  probable glutathione peroxidase 8 isoform X1

    Conserved Domains (1) summary
    TIGR02540
    Location:46199
    gpx7; putative glutathione peroxidase Gpx7
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