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TRIM72 tripartite motif containing 72 [ Homo sapiens (human) ]

Gene ID: 493829, updated on 13-May-2022

Summary

Official Symbol
TRIM72provided by HGNC
Official Full Name
tripartite motif containing 72provided by HGNC
Primary source
HGNC:HGNC:32671
See related
Ensembl:ENSG00000177238 MIM:613288; AllianceGenome:HGNC:32671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MG53
Summary
Enables identical protein binding activity. Predicted to be involved in several processes, including cellular protein metabolic process; plasma membrane repair; and protein homooligomerization. Predicted to act upstream of or within negative regulation of insulin receptor signaling pathway; negative regulation of insulin-like growth factor receptor signaling pathway; and negative regulation of myotube differentiation. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be active in cytoplasm and sarcolemma. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in prostate (RPKM 2.0), esophagus (RPKM 0.3) and 1 other tissue See more
Orthologs
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Genomic context

See TRIM72 in Genome Data Viewer
Location:
16p11.2
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (31214119..31231537)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (31601549..31618973)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31225440..31242858)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene FUS RNA binding protein Neighboring gene PYCARD antisense RNA 1 Neighboring gene PYD and CARD domain containing Neighboring gene pyrin domain containing 1 Neighboring gene integrin subunit alpha M Neighboring gene integrin subunit alpha X pseudogene Neighboring gene integrin subunit alpha X

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin conjugating enzyme binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in muscle organ development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in muscle system process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of myotube differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in plasma membrane repair ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein homooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasmic vesicle membrane TAS
Traceable Author Statement
more info
 
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sarcolemma ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
tripartite motif-containing protein 72
Names
mitsugumin-53
tripartite motif containing 72, E3 ubiquitin protein ligase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008274.4NP_001008275.2  tripartite motif-containing protein 72

    See identical proteins and their annotated locations for NP_001008275.2

    Status: VALIDATED

    Source sequence(s)
    AC009088, AK131485, DA058421
    Consensus CDS
    CCDS32437.1
    UniProtKB/Swiss-Prot
    Q6ZMU5
    Related
    ENSP00000312675.3, ENST00000322122.8
    Conserved Domains (3) summary
    cd13742
    Location:278470
    SPRY_PRY_TRIM72; PRY/SPRY domain in tripartite motif-binding protein 72 (TRIM72)
    cd16612
    Location:1157
    RING-HC_TRIM72_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 72 (TRIM72) and similar proteins
    cl00034
    Location:84125
    Bbox_SF; B-box-type zinc finger superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    31214119..31231537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    31601549..31618973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)