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TRIM72 tripartite motif containing 72 [ Homo sapiens (human) ]

Gene ID: 493829, updated on 1-Aug-2020

Summary

Official Symbol
TRIM72provided by HGNC
Official Full Name
tripartite motif containing 72provided by HGNC
Primary source
HGNC:HGNC:32671
See related
Ensembl:ENSG00000177238 MIM:613288
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MG53
Expression
Biased expression in prostate (RPKM 2.0), esophagus (RPKM 0.3) and 1 other tissue See more
Orthologs

Genomic context

See TRIM72 in Genome Data Viewer
Location:
16p11.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (31214119..31231537)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31225342..31236510)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene FUS RNA binding protein Neighboring gene PYCARD antisense RNA 1 Neighboring gene PYD and CARD domain containing Neighboring gene pyrin domain containing 1 Neighboring gene integrin subunit alpha M Neighboring gene integrin subunit alpha X pseudogene Neighboring gene integrin subunit alpha X

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
exocytosis IEA
Inferred from Electronic Annotation
more info
 
muscle contraction TAS
Traceable Author Statement
more info
 
muscle organ development ISS
Inferred from Sequence or Structural Similarity
more info
 
muscle system process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myotube differentiation IEA
Inferred from Electronic Annotation
more info
 
plasma membrane repair ISS
Inferred from Sequence or Structural Similarity
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic vesicle membrane TAS
Traceable Author Statement
more info
 
sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sarcolemma ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
tripartite motif-containing protein 72
Names
mitsugumin-53
tripartite motif containing 72, E3 ubiquitin protein ligase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008274.4NP_001008275.2  tripartite motif-containing protein 72

    See identical proteins and their annotated locations for NP_001008275.2

    Status: VALIDATED

    Source sequence(s)
    AC009088, AK131485, DA058421
    Consensus CDS
    CCDS32437.1
    UniProtKB/Swiss-Prot
    Q6ZMU5
    Related
    ENSP00000312675.3, ENST00000322122.8
    Conserved Domains (3) summary
    cd13742
    Location:278470
    SPRY_PRY_TRIM72; PRY/SPRY domain in tripartite motif-binding protein 72 (TRIM72)
    pfam00643
    Location:81121
    zf-B_box; B-box zinc finger
    cd16612
    Location:1157
    RING-HC_TRIM72_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 72 (TRIM72) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    31214119..31231537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023254.1XP_016878743.1  tripartite motif-containing protein 72 isoform X1

    Conserved Domains (1) summary
    cd13742
    Location:134326
    SPRY_PRY_TRIM72; PRY/SPRY domain in tripartite motif-binding protein 72 (TRIM72)
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