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OAS1 2'-5'-oligoadenylate synthetase 1 [ Homo sapiens (human) ]

Gene ID: 4938, updated on 7-Jun-2020

Summary

Official Symbol
OAS1provided by HGNC
Official Full Name
2'-5'-oligoadenylate synthetase 1provided by HGNC
Primary source
HGNC:HGNC:8086
See related
Ensembl:ENSG00000089127 MIM:164350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OIAS; IFI-4; OIASI; E18/E16
Summary
This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in spleen (RPKM 18.0), colon (RPKM 15.8) and 24 other tissues See more
Orthologs

Genomic context

See OAS1 in Genome Data Viewer
Location:
12q24.13
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (112906777..112933219)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (113344739..113357712)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase non-receptor type 11 Neighboring gene rabphilin 3A Neighboring gene microRNA 1302-1 Neighboring gene 2'-5'-oligoadenylate synthetase 3 Neighboring gene 2'-5'-oligoadenylate synthetase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population.
NHGRI GWA Catalog
Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of 2'-5'-oligoadenylate synthetase 1 (OAS1) in human B cells PubMed
Nef nef Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Nef may antagonize restriction activity of OAS1 against production of infectious wild-type HIV-1 PubMed
Tat tat HIV-1 and the viral protein Tat modulate the expression of 2',5'-oligoadenylate synthetase 1, 40/46kDa (OAS1) in immature dendritic cells and monocyte-derived macrophages PubMed
tat HIV-1 Tat interacts with interferon-inducible enzymes 2-5A synthetase and dsRNA-dependent protein kinase to influence the rate of translation and protein synthesis in vitro PubMed
Vpr vpr Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Vpr may antagonize restriction activity of OAS1 against production of infectious wild-type HIV-1 PubMed
Vpu vpu Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Vpu may antagonize restriction activity of OAS1 against production of infectious wild-type HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
2'-5'-oligoadenylate synthetase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
2'-5'-oligoadenylate synthetase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding TAS
Traceable Author Statement
more info
PubMed 
double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to virus TAS
Traceable Author Statement
more info
 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
colocalizes_with cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
2'-5'-oligoadenylate synthase 1
Names
(2-5')oligo(A) synthase 1
2',5'-oligo A synthetase 1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
2'-5'-oligoisoadenylate synthetase 1
2-5A synthase 1
2-5A synthetase 1
E16 (2'-5') oligo A synthetase
NP_001027581.1
NP_001307080.1
NP_002525.2
NP_058132.2
XP_006719497.1
XP_011536715.1
XP_016874850.1
XP_016874851.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011530.2 RefSeqGene

    Range
    5029..17970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032409.3NP_001027581.1  2'-5'-oligoadenylate synthase 1 isoform 3

    See identical proteins and their annotated locations for NP_001027581.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3 (also known as p48), which has a longer, distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AJ629455, AY730628, BF055326, CB112445
    Consensus CDS
    CCDS31905.1
    UniProtKB/Swiss-Prot
    P00973
    Related
    ENSP00000388001.2, ENST00000445409.6
    Conserved Domains (2) summary
    cd05400
    Location:29211
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:163343
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
  2. NM_001320151.2NP_001307080.1  2'-5'-oligoadenylate synthase 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR compared to variant 1. It encodes isoform 4 (also known as p44b), which has a shorter, distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA085948, AC004551, AJ629455, CB112445
    Consensus CDS
    CCDS81742.1
    UniProtKB/Swiss-Prot
    P00973
    UniProtKB/TrEMBL
    F8VXY3
    Related
    ENSP00000448790.1, ENST00000551241.5
    Conserved Domains (2) summary
    cd05400
    Location:29211
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:163343
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
  3. NM_002534.3NP_002525.2  2'-5'-oligoadenylate synthase 1 isoform 2

    See identical proteins and their annotated locations for NP_002525.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 (also known as E16, p40, or p42), which has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC061587, BE048946, CB112445
    Consensus CDS
    CCDS44980.1
    UniProtKB/Swiss-Prot
    P00973
    Related
    ENSP00000415721.2, ENST00000452357.6
    Conserved Domains (2) summary
    cd05400
    Location:29211
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:163343
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
  4. NM_016816.4NP_058132.2  2'-5'-oligoadenylate synthase 1 isoform 1

    See identical proteins and their annotated locations for NP_058132.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. It encodes isoform 1 (also known as E18 and p46). This variant is produced in individuals with a G allele at a polymorphic splice acceptor site in the 3' most intron(PMID:15732009).
    Source sequence(s)
    AJ629455, AK225384, CB112445
    Consensus CDS
    CCDS41838.1
    UniProtKB/Swiss-Prot
    P00973
    Related
    ENSP00000202917.5, ENST00000202917.10
    Conserved Domains (2) summary
    cd05400
    Location:29211
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:163343
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    112906777..112933219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019361.2XP_016874850.1  2'-5'-oligoadenylate synthase 1 isoform X2

  2. XM_011538413.2XP_011536715.1  2'-5'-oligoadenylate synthase 1 isoform X1

    Conserved Domains (2) summary
    cd05400
    Location:29156
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:210335
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
  3. XM_006719434.2XP_006719497.1  2'-5'-oligoadenylate synthase 1 isoform X3

    Conserved Domains (2) summary
    cd05400
    Location:29211
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:163343
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
  4. XM_017019362.1XP_016874851.1  2'-5'-oligoadenylate synthase 1 isoform X4

RNA

  1. XR_944558.2 RNA Sequence

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