extl3 exostosin-like glycosyltransferase 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: extl3provided by ZNC
Official Full Name: exostosin-like glycosyltransferase 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-041124-2
See related: Ensembl:ENSDARG00000026811 AllianceGenome:ZFIN:ZDB-GENE-041124-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7141548
Summary: Predicted to enable glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Acts upstream of or within several processes, including axon guidance; embryonic pectoral fin morphogenesis; and proteoglycan biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus. Is expressed in nervous system and pectoral fin musculature. Orthologous to human EXTL3 (exostosin like glycosyltransferase 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	20	NC_133195.1 (53148460..53225887, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (49937995..50014992, complement)

Chromosome 20 - NC_133195.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of chondroitin sulfate and heparan sulfate biosynthesis in zebrafish larvae homozygous for mutations in ext2, extl3, uxs1, or b3gat3
Title: On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis.
Ext2 and extl3 are differentially required for Fgf10, but not Fgf4, signalling during limb development.
Title: HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables glycosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic pectoral fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response to wounding	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pectoral fin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pectoral fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of keratinocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein glycosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thymus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: exostosin-like 3

Names: box; boxer; exostoses (multiple)-like 3

NP_001008402.1

EC 2.4.1.223

XP_005170268.1

EC 2.4.1.223

XP_073788493.1

EC 2.4.1.223

XP_073788494.1

EC 2.4.1.223

XP_073788495.1

EC 2.4.1.223

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008402.1 → NP_001008402.1 exostosin-like 3

See identical proteins and their annotated locations for NP_001008402.1

Status: PROVISIONAL

Source sequence(s)

AY786436

UniProtKB/TrEMBL

A0A2R8QIT5, F8W3U5, Q5U7D2

Related

ENSDARP00000155128.1, ENSDART00000187569.1

Conserved Domains (3) summary

pfam03016
Location:183 → 498

Exostosin; Exostosin family

pfam09258
Location:661 → 894

Glyco_transf_64; Glycosyl transferase family 64 domain

cl23720
Location:79 → 143

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)