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MAN2B1 mannosidase alpha class 2B member 1 [ Felis catus (domestic cat) ]

Gene ID: 493697, updated on 17-Aug-2024

Summary

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Official Symbol
MAN2B1
Official Full Name
mannosidase alpha class 2B member 1
Primary source
VGNC:VGNC:111315
See related
EnsemblRapid:ENSFCTG00005031301
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Also known as
MANB
Orthologs
human mouse all
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Genomic context

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See MAN2B1 in Genome Data Viewer
Location:
chromosome: A2
Exon count:
24
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) A2 NC_058369.1 (8950052..8965933, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) A2 NC_018724.3 (9005210..9021069, complement)

Chromosome A2 - NC_058369.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 709-like Neighboring gene transfer RNA arginine (anticodon UCG) Neighboring gene zinc finger protein 791 Neighboring gene WD repeat domain 83 opposite strand Neighboring gene WD repeat domain 83 Neighboring gene deoxyhypusine synthase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification of feline lysosomal alpha-mannosidase, determination of its cDNA sequence and identification of a mutation causing alpha-mannosidosis in Persian cats. Berg T, et al. Biochem J, 1997 Dec 15. PMID 9396732, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mannose metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
lysosomal alpha-mannosidase
Names
laman
lysosomal acid alpha-mannosidase
mannosidase alpha-B
NP_001009222.1
XP_006928517.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009222.1 → NP_001009222.1  lysosomal alpha-mannosidase precursor

    See identical proteins and their annotated locations for NP_001009222.1

    Status: PROVISIONAL

    Source sequence(s)
    AF010191
    UniProtKB/Swiss-Prot
    O46432
    UniProtKB/TrEMBL
    A0A2I2UJS0
    Related
    ENSFCTP00005059040.1, ENSFCTT00005087199.1
    Conserved Domains (4) summary
    PLN02701
    Location:64 → 997
    PLN02701; alpha-mannosidase
    cd10810
    Location:64 → 342
    GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
    smart00872
    Location:389 → 467
    Alpha-mann_mid; Alpha mannosidase, middle domain
    pfam07748
    Location:512 → 997
    Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain

RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058369.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    8950052..8965933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006928455.4 → XP_006928517.2  lysosomal alpha-mannosidase isoform X1

    UniProtKB/TrEMBL
    A0A2I2UJS0
    Related
    ENSFCTP00005058980.1, ENSFCTT00005087090.1
    Conserved Domains (2) summary
    PLN02701
    Location:64 → 996
    PLN02701; alpha-mannosidase
    cd10810
    Location:64 → 342
    GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46432.1 GenPept UniProtKB/Swiss-Prot:O46432

Gene LinkOut

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