U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pcdh2ab12 protocadherin 2 alpha b 12 [ Danio rerio (zebrafish) ]

Gene ID: 493600, updated on 5-Jul-2025
Official Symbol
pcdh2ab12provided by ZNC
Official Full Name
protocadherin 2 alpha b 12provided by ZNC
Primary source
ZFIN:ZDB-GENE-041118-11
See related
Ensembl:ENSDARG00000104080 AllianceGenome:ZFIN:ZDB-GENE-041118-11
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zcnrv12; zCNRv7ss-1
Summary
Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including PCDHA8 (protocadherin alpha 8). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table
See pcdh2ab12 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 14 NC_133189.1 (2633786..2700373, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 14 NC_007125.7 (2123123..2187202, complement)

Chromosome 14 - NC_133189.1Genomic Context describing neighboring genes Neighboring gene protocadherin 2 gamma 16 Neighboring gene protocadherin 2 gamma 13 Neighboring gene protocadherin 2 gamma 12 Neighboring gene protocadherin 2 gamma 17 Neighboring gene protocadherin 2 gamma 9 Neighboring gene protocadherin 2 gamma 8 Neighboring gene protocadherin 2 gamma 7 Neighboring gene protocadherin 2 gamma 6 Neighboring gene protocadherin 2 gamma 5 Neighboring gene protocadherin 2 gamma 2 Neighboring gene protocadherin 2 gamma 1 Neighboring gene protocadherin beta-16-like Neighboring gene protocadherin 2 gamma 3 Neighboring gene protocadherin 2 alpha b 10 Neighboring gene protocadherin 2 alpha a 15 Neighboring gene protocadherin 2 alpha b 9 Neighboring gene protocadherin 2 alpha b 7 Neighboring gene protocadherin 2 alpha b 5 Neighboring gene protocadherin 2 alpha b 3 Neighboring gene protocadherin 2 alpha b2 Neighboring gene protocadherin 2 alpha a 3 Neighboring gene protocadherin 2 alpha a 1 Neighboring gene protocadherin 2 alpha c Neighboring gene protocadherin alpha-3-like Neighboring gene protocadherin alpha-3-like

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Regulation of protocadherin gene expression by multiple neuron-restrictive silencer elements scattered in the gene cluster. Tan YP, et al. Nucleic Acids Res, 2010 Aug. PMID 20385576, Free PMC Article
  2. Genomic organization and transcripts of the zebrafish Protocadherin genes. Tada MN, et al. Gene, 2004 Oct 13. PMID 15475161
  3. Gene conversion and the evolution of protocadherin gene cluster diversity. Noonan JP, et al. Genome Res, 2004 Mar. PMID 14993203, Free PMC Article
  4. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, et al. Genome Res, 2004 Jan. PMID 14672974, Free PMC Article
  5. Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes. Wu Q. Genetics, 2005 Apr. PMID 15744052, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protocadherin 2 alpha b 12
Names
cadherin-related neuronal receptor variable 12
cadherin-related neuronal receptor variable 9 short splicing form 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009591.2 → NP_001009591.2  protocadherin 2 alpha b 12 precursor

    Status: VALIDATED

    Source sequence(s)
    CR847851, CT573264
    UniProtKB/TrEMBL
    A0A8M1N3Y1, Q60I65
    Related
    ENSDARP00000130636.1, ENSDART00000160205.2
    Conserved Domains (4) summary
    cd11304
    Location:243 → 343
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:26 → 108
    Cadherin_2; Cadherin-like
    pfam15974
    Location:795 → 912
    Cadherin_tail; Cadherin C-terminal cytoplasmic tail, catenin-binding region
    pfam16492
    Location:686 → 758
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133189.1 Reference GRCz12tu Primary Assembly

    Range
    2633786..2700373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools