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spred1 sprouty related, EVH1 domain containing 1 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 493399, updated on 5-Sep-2025
Official Symbol
spred1provided by Xenbase
Official Full Name
sprouty related, EVH1 domain containing 1provided by Xenbase
Primary source
Xenbase:XB-GENE-482851
See related
Ensembl:ENSXETG00000018057 AllianceGenome:Xenbase:XB-GENE-482851
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
Xspred1; Xtspred1
Summary
Predicted to enable phosphatase binding activity. Predicted to act upstream of or within regulation of signal transduction. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in Legius syndrome. Orthologous to human SPRED1 (sprouty related EVH1 domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See spred1 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
6
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 8 NC_030684.2 (110791673..110841608, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 8 NC_030684.1 (90501110..90551512, complement)

Chromosome 8 - NC_030684.2Genomic Context describing neighboring genes Neighboring gene decreased expression in renal and prostate cancer protein-like Neighboring gene family with sequence similarity 98 member B Neighboring gene uncharacterized LOC100498462 Neighboring gene Meis homeobox 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. 1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family. Harmer NJ, et al. FEBS Lett, 2005 Feb 14. PMID 15710406
  2. FGF signal interpretation is directed by Sprouty and Spred proteins during mesoderm formation. Sivak JM, et al. Dev Cell, 2005 May. PMID 15866160
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spred1 and 2 inhibit MAPK activation and mesoderm specification, with little effect on Ca(2+) or PKCdelta signaling.
    Title: FGF signal interpretation is directed by Sprouty and Spred proteins during mesoderm formation.
  2. crystal structure of the Enabled/vasodilator-stimulated phosphoprotein homology-1 (EVH1) domain from Xenopus tropicalis Spred1, solved to 1.15 A resolution
    Title: 1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family.
Submit: New GeneRIF Correction

Homology

Clone Names

  • MGC79569

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
sprouty-related, EVH1 domain-containing protein 1
Names
spred-1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008036.1 → NP_001008037.1  sprouty-related, EVH1 domain-containing protein 1

    See identical proteins and their annotated locations for NP_001008037.1

    Status: PROVISIONAL

    Source sequence(s)
    BC080919
    UniProtKB/Swiss-Prot
    Q66JG9
    UniProtKB/TrEMBL
    A0A803J3S4
    Related
    ENSXETP00000039156.5, ENSXETT00000039156.5
    Conserved Domains (2) summary
    cd10574
    Location:10 → 122
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    pfam05210
    Location:297 → 390
    Sprouty; Sprouty protein (Spry)

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    110791673..110841608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66JG9.1 GenPept UniProtKB/Swiss-Prot:Q66JG9

Gene LinkOut

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Molecular Biology Databases
Research Materials