azin1 antizyme inhibitor 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: azin1provided by Xenbase
Official Full Name: antizyme inhibitor 1provided by Xenbase
Primary source: Xenbase:XB-GENE-948396
See related: Ensembl:ENSXETG00000004118 AllianceGenome:Xenbase:XB-GENE-948396
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: oazin
Summary: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. [provided by RefSeq, Sep 2014]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	6	NC_030682.2 (131426777..131443188, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	6	NC_030682.1 (118627632..118644426)

Chromosome 6 - NC_030682.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables ornithine decarboxylase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine decarboxylase activator activity	IEA Inferred from Electronic Annotation more info
enables ornithine decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in polyamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of polyamine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in putrescine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: antizyme inhibitor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007943.2 → NP_001007944.1 antizyme inhibitor 1

See identical proteins and their annotated locations for NP_001007944.1

Status: REVIEWED

Source sequence(s)

AL898289, BX702262, CN109697, CR761232

UniProtKB/TrEMBL

A0A8J1JRG8, F6SRX9, Q66KD4

Related

ENSXETP00000008894.3, ENSXETT00000008894.5

Conserved Domains (1) summary

cd06831
Location:26 → 417

PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030682.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

131426777..131443188 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_031903322.1 → XP_031759182.1 antizyme inhibitor 1 isoform X2

UniProtKB/TrEMBL

A0A8J1JMS2

Conserved Domains (1) summary

cl00261
Location:1 → 252

PLPDE_III; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes
XM_031903321.1 → XP_031759181.1 antizyme inhibitor 1 isoform X1

UniProtKB/TrEMBL

A0A8J1JRG8, F6SRX9, Q66KD4

Conserved Domains (1) summary

cd06831
Location:26 → 417

PLPDE_III_ODC_like_AZI; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase-like Antizyme Inhibitor