smad3 SMAD family member 3 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: smad3provided by Xenbase
Official Full Name: SMAD family member 3provided by Xenbase
Primary source: Xenbase:XB-GENE-481992
See related: Ensembl:ENSXETG00000007804
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: Xmad3; madh3; XSmad3; XenMLP; jv15-2; hspc193; hst17436
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	3	NC_030679.2 (117365966..117426998)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	3	NC_030679.1 (116708039..116789519, complement)

Chromosome 3 - NC_030679.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Smad2-Smad2 and Smad2-Smad4 complexes accumulate rapidly in the nuclei of responding cells following Activin treatment.
Title: Nuclear accumulation of Smad complexes occurs only after the midblastula transition in Xenopus.

Submit: New GeneRIF Correction

General gene information

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Markers

Smad3 (e-PCR), detects polymorphism
- UniSTS:466571

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mothers against decapentaplegic homolog 3

Names: mothers against DPP homolog 3; smad 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008436.2 → NP_001008436.1 mothers against decapentaplegic homolog 3

See identical proteins and their annotated locations for NP_001008436.1

Status: PROVISIONAL

Source sequence(s)

BC080156

UniProtKB/TrEMBL

A0A6I8PPP3, Q68EP5

Related

ENSXETP00000064162.2, ENSXETT00000101227.2

Conserved Domains (2) summary

cd10491
Location:8 → 132

MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3

cd10985
Location:224 → 414

MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3