angptl4 angiopoietin-like 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: angptl4provided by ZNC
Official Full Name: angiopoietin-like 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-041111-222
See related: Ensembl:ENSDARG00000035859 AllianceGenome:ZFIN:ZDB-GENE-041111-222
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fiaf; im:7144703; si:rp71-39b20.7
Summary: Predicted to enable enzyme inhibitor activity. Acts upstream of or within apoptotic process involved in blood vessel morphogenesis and response to bacterium. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in endocrine pancreas; intestinal epithelium; intestine; and liver. Orthologous to human ANGPTL4 (angiopoietin like 4). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	2	NC_133177.1 (27867472..27873233)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (24536761..24542522)

Chromosome 2 - NC_133177.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

angptl4 gene expression as a marker of adaptive homeostatic response to social isolation across the lifespan in zebrafish.
Title: angptl4 gene expression as a marker of adaptive homeostatic response to social isolation across the lifespan in zebrafish.
These results suggest that the microbiota might regulate host intestinal Angptl4 protein expression and peripheral fat storage by suppressing the activity of an intestine-specific transcriptional enhancer.
Title: Intronic cis-regulatory modules mediate tissue-specific and microbial control of angptl4/fiaf transcription.

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General gene information

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Markers

fj89c07.y1 (e-PCR)
- UniSTS:200243

fb98d07.y1 (e-PCR)
- UniSTS:191964

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables enzyme inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride homeostasis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: angiopoietin-related protein 4

Names: angiopoietin-like 4 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256203.1 → NP_001243132.1 angiopoietin-related protein 4 precursor

Status: VALIDATED

Source sequence(s)

JBMGRA010000002

UniProtKB/TrEMBL

A0A8M1NYZ0

Related

ENSDARP00000122994.1, ENSDART00000144149.3

Conserved Domains (2) summary

cd00087
Location:240 → 453

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam16043
Location:78 → 224

DUF4795; Domain of unknown function (DUF4795)