cetp cholesteryl ester transfer protein, plasma [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cetpprovided by ZNC
Official Full Name: cholesteryl ester transfer protein, plasmaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041114-54
See related: Ensembl:ENSDARG00000030872 AllianceGenome:ZFIN:ZDB-GENE-041114-54
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:103675
Summary: Predicted to enable several functions, including cholesterol binding activity; phosphatidylcholine binding activity; and triglyceride binding activity. Predicted to be involved in several processes, including cholesterol homeostasis; glycerolipid metabolic process; and plasma lipoprotein particle remodeling. Predicted to act upstream of or within reverse cholesterol transport and steroid metabolic process. Predicted to be located in extracellular region. Predicted to be part of high-density lipoprotein particle. Is expressed in asteriscus; liver; otic vesicle; and yolk syncytial layer. Human ortholog(s) of this gene implicated in carotid artery disease and hyperalphalipoproteinemia 1. Orthologous to human CETP (cholesteryl ester transfer protein). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	18	NC_133193.1 (18996545..19006749)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (17611624..17621821)

Chromosome 18 - NC_133193.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol transfer activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine binding	IBA Inferred from Biological aspect of Ancestor more info
enables triglyceride binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol transport	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in low-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylcholine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in reverse cholesterol transport	IEA Inferred from Electronic Annotation more info
involved_in triglyceride homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride transport	IEA Inferred from Electronic Annotation more info
involved_in very-low-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in very-low-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of high-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cholesteryl ester transfer protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007360.1 → NP_001007361.1 cholesteryl ester transfer protein precursor

See identical proteins and their annotated locations for NP_001007361.1

Status: PROVISIONAL

Source sequence(s)

BC085584

UniProtKB/TrEMBL

A0A8M1N3A1, A0ACM8Q5Z5, Q5U3E2

Related

ENSDARP00000046890.6, ENSDART00000046891.7

Conserved Domains (1) summary

cl00188
Location:31 → 256

BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...