U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ace2 angiotensin I converting enzyme 2 [ Danio rerio (zebrafish) ]

Gene ID: 492331, updated on 9-Sep-2025
Official Symbol
ace2provided by ZNC
Official Full Name
angiotensin I converting enzyme 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-041114-6
See related
Ensembl:ENSDARG00000016918 AllianceGenome:ZFIN:ZDB-GENE-041114-6
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92514
Summary
Predicted to enable carboxypeptidase activity and metallopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in several cellular components, including apical plasma membrane; cilium; and extracellular region. Predicted to be active in extracellular space and plasma membrane. Is expressed in brain; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See ace2 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 11 NC_133186.1 (32217279..32232019, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 11 NC_007122.7 (29981678..29996360, complement)

Chromosome 11 - NC_133186.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438539 Neighboring gene si:ch73-226l13.2 Neighboring gene interleukin-1 family member A Neighboring gene Nance-Horan syndrome b (congenital cataracts and dental anomalies) Neighboring gene cyclin dependent kinase like 5 Neighboring gene Scm polycomb group protein like 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. ACE2 orthologues in non-mammalian vertebrates (Danio, Gallus, Fugu, Tetraodon and Xenopus). Chou CF, et al. Gene, 2006 Aug 1. PMID 16781089, Free PMC Article
  2. Intranasal delivery of SARS-CoV-2 spike protein is sufficient to cause olfactory damage, inflammation and olfactory dysfunction in zebrafish. Kraus A, et al. Brain Behav Immun, 2022 May. PMID 35307504, Free PMC Article
  3. Functional analysis of co-expression networks of zebrafish ace2 reveals enrichment of pathways associated with development and disease. Keskus AG, et al. Genome, 2022 Feb. PMID 34606733
  4. Structural libraries of protein models for multiple species to understand evolution of the renin-angiotensin system. Prokop JW, et al. Gen Comp Endocrinol, 2015 May 1. PMID 25260253, Free PMC Article
  5. Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell Entry. Choi SSA, et al. J Virol, 2022 Dec 21. PMID 36448804, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional analysis of co-expression networks of zebrafish ace2 reveals enrichment of pathways associated with development and disease.
    Title: Functional analysis of co-expression networks of zebrafish ace2 reveals enrichment of pathways associated with development and disease.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxypeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-dipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in angiotensin maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
angiotensin-converting enzyme 2
Names
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
XP_005169416.1
XP_005169417.1
XP_068080258.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007297.2 → NP_001007298.2  angiotensin-converting enzyme 2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000011

  2. NM_001442150.1 → NP_001429079.1  angiotensin-converting enzyme 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000011

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133186.1 Reference GRCz12tu Primary Assembly

    Range
    32217279..32232019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005169360.5 → XP_005169417.1  angiotensin-converting enzyme 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BGN5
    Conserved Domains (2) summary
    cd06461
    Location:27 → 598
    M2_ACE; Peptidase family M2 Angiotensin converting enzyme (ACE)
    pfam16959
    Location:619 → 770
    Collectrin; Renal amino acid transporter

  2. XM_005169359.5 → XP_005169416.1  angiotensin-converting enzyme 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BGQ7, E7F9E5
    Related
    ENSDARP00000106752.2, ENSDART00000126110.4
    Conserved Domains (2) summary
    cd06461
    Location:27 → 598
    M2_ACE; Peptidase family M2 Angiotensin converting enzyme (ACE)
    pfam16959
    Location:630 → 781
    Collectrin; Renal amino acid transporter

  3. XM_068224157.1 → XP_068080258.1  angiotensin-converting enzyme 2 isoform X3

    UniProtKB/TrEMBL
    A0AB32TXH6
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools