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ARHGAP4 Rho GTPase activating protein 4 [ Canis lupus familiaris (dog) ]

Gene ID: 492245, updated on 25-Jul-2026
Official Symbol
ARHGAP4provided by VGNC
Official Full Name
Rho GTPase activating protein 4provided by VGNC
Primary source
VGNC:VGNC:38063
See related
Ensembl:ENSCAFG00845026108 RGD:12259686
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See ARHGAP4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
25
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (124896249..124913499, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (107083712..107100978, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (122942263..122959510, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (120665512..120682776, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (123180944..123198176, complement)

Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene L1 cell adhesion molecule Neighboring gene arginine vasopressin receptor 2 Neighboring gene N-alpha-acetyltransferase 10, NatA catalytic subunit Neighboring gene renin binding protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
rho GTPase-activating protein 4

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051843.1 Reference ROS_Cfam_1.0

    Range
    124896249..124913499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038451247.1 → XP_038307175.1  rho GTPase-activating protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LFI7, A0A8I3S9X0
    Related
    ENSCAFP00845036177.1, ENSCAFT00845046075.1
    Conserved Domains (3) summary
    cd07656
    Location:26 → 292
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:514 → 701
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:760 → 813
    SH3; Src Homology 3 domain superfamily

  2. XM_038451249.1 → XP_038307177.1  rho GTPase-activating protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LFI7
    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily

  3. XM_038451248.1 → XP_038307176.1  rho GTPase-activating protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LFI7
    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily

  4. XM_038451250.1 → XP_038307178.1  rho GTPase-activating protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LFI7
    Related
    ENSCAFP00845036352.1, ENSCAFT00845046289.1
    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049299.1 Alternate UMICH_Zoey_3.1

    Range
    120665512..120682776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038524714.1 → XP_038380642.1  

    Conserved Domains (3) summary
    cd07656
    Location:26 → 292
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:514 → 701
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:760 → 813
    SH3; Src Homology 3 domain superfamily

  2. XM_038524718.1 → XP_038380646.1  

    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily

  3. XM_038524716.1 → XP_038380644.1  

    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily

  4. XM_038524719.1 → XP_038380647.1  

    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily

  5. XM_038524717.1 → XP_038380645.1  

    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily

  6. XM_038524715.1 → XP_038380643.1  

    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

    Range
    123180944..123198176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038653200.1 → XP_038509128.1  

    Conserved Domains (3) summary
    cd07656
    Location:26 → 292
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:514 → 701
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:760 → 813
    SH3; Src Homology 3 domain superfamily

  2. XM_038653202.1 → XP_038509130.1  

    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily

  3. XM_038653201.1 → XP_038509129.1  

    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily

  4. XM_038653203.1 → XP_038509131.1  

    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

    Range
    122942263..122959510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038588679.1 → XP_038444607.1  rho GTPase-activating protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LFI7, A0A8I3S9X0
    Conserved Domains (3) summary
    cd07656
    Location:26 → 292
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:514 → 701
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:760 → 813
    SH3; Src Homology 3 domain superfamily

  2. XM_038588681.1 → XP_038444609.1  rho GTPase-activating protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LFI7
    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily

  3. XM_038588680.1 → XP_038444608.1  rho GTPase-activating protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LFI7
    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily

  4. XM_038588682.1 → XP_038444610.1  rho GTPase-activating protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LFI7
    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    107083712..107100978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_549365.8 → XP_549365.3  rho GTPase-activating protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LFI7, A0A8I3S9X0
    Conserved Domains (3) summary
    cd07656
    Location:26 → 292
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:514 → 701
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:760 → 813
    SH3; Src Homology 3 domain superfamily

  2. XM_038464866.1 → XP_038320794.1  rho GTPase-activating protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LFI7
    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily

  3. XM_038464864.1 → XP_038320792.1  rho GTPase-activating protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LFI7
    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily

  4. XM_005642001.4 → XP_005642058.1  rho GTPase-activating protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LFI7
    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily

  5. XM_038464865.1 → XP_038320793.1  rho GTPase-activating protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LFI7
    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:737 → 790
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
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