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AFF2 ALF transcription elongation factor 2 [ Canis lupus familiaris (dog) ]

Gene ID: 492193, updated on 25-Jul-2026
Official Symbol
AFF2provided by VGNC
Official Full Name
ALF transcription elongation factor 2provided by VGNC
Primary source
VGNC:VGNC:49896
See related
Ensembl:ENSCAFG00845021181 RGD:12207860
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See AFF2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (118755641..119226966)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (102589304..103060400)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (117807028..118275870)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (115868624..116336571)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (118079841..118547888)

Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC119868242 Neighboring gene uncharacterized LOC111094925 Neighboring gene uncharacterized LOC102153113

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G-quadruplex RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of RNA splicing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
AF4/FMR2 family member 2

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051843.1 Reference ROS_Cfam_1.0

    Range
    118755641..119226966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038451057.1 → XP_038306985.1  AF4/FMR2 family member 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I3PGJ9
    Related
    ENSCAFP00845029585.1, ENSCAFT00845037754.1
    Conserved Domains (4) summary
    PTZ00449
    Location:587 → 865
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:18 → 529
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:794 → 808
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1048 → 1303
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  2. XM_038451055.1 → XP_038306983.1  AF4/FMR2 family member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PGJ9
    Conserved Domains (4) summary
    PTZ00449
    Location:598 → 876
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 540
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:805 → 819
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1059 → 1314
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  3. XM_038451058.1 → XP_038306986.1  AF4/FMR2 family member 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I3PGT9
    Conserved Domains (4) summary
    PTZ00449
    Location:569 → 847
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 511
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:776 → 790
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1030 → 1285
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  4. XM_038451056.1 → XP_038306984.1  AF4/FMR2 family member 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PGJ9
    Conserved Domains (4) summary
    PTZ00449
    Location:594 → 872
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 536
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:801 → 815
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1055 → 1310
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  5. XM_038451059.1 → XP_038306987.1  AF4/FMR2 family member 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I3PGT9
    Conserved Domains (4) summary
    PTZ00449
    Location:565 → 843
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 507
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:772 → 786
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1026 → 1281
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  6. XM_038451060.1 → XP_038306988.1  AF4/FMR2 family member 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I3PCN3
    Related
    ENSCAFP00845029790.1, ENSCAFT00845038016.1
    Conserved Domains (4) summary
    PTZ00449
    Location:307 → 585
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:64 → 249
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:514 → 528
    AF4_int; AF4 interaction motif
    pfam18876
    Location:768 → 1023
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  7. XM_038451061.1 → XP_038306989.1  AF4/FMR2 family member 2 isoform X7

    UniProtKB/TrEMBL
    A0A8I3PCN3
    Conserved Domains (4) summary
    PTZ00449
    Location:278 → 556
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:64 → 220
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:485 → 499
    AF4_int; AF4 interaction motif
    pfam18876
    Location:739 → 994
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049299.1 Alternate UMICH_Zoey_3.1

    Range
    115868624..116336571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038524525.1 → XP_038380453.1  

    Conserved Domains (4) summary
    PTZ00449
    Location:587 → 865
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:18 → 529
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:794 → 808
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1048 → 1303
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  2. XM_038524523.1 → XP_038380451.1  

    Conserved Domains (4) summary
    PTZ00449
    Location:598 → 876
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 540
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:805 → 819
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1059 → 1314
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  3. XM_038524526.1 → XP_038380454.1  

    Conserved Domains (4) summary
    PTZ00449
    Location:569 → 847
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 511
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:776 → 790
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1030 → 1285
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  4. XM_038524524.1 → XP_038380452.1  

    Conserved Domains (4) summary
    PTZ00449
    Location:594 → 872
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 536
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:801 → 815
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1055 → 1310
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  5. XM_038524527.1 → XP_038380455.1  

    Conserved Domains (4) summary
    PTZ00449
    Location:565 → 843
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 507
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:772 → 786
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1026 → 1281
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  6. XM_038524528.1 → XP_038380456.1  

    Conserved Domains (4) summary
    PTZ00449
    Location:307 → 585
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:64 → 249
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:514 → 528
    AF4_int; AF4 interaction motif
    pfam18876
    Location:768 → 1023
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  7. XM_038524529.1 → XP_038380457.1  

    Conserved Domains (4) summary
    PTZ00449
    Location:278 → 556
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:64 → 220
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:485 → 499
    AF4_int; AF4 interaction motif
    pfam18876
    Location:739 → 994
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

    Range
    118079841..118547888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038653016.1 → XP_038508944.1  

    Conserved Domains (4) summary
    PTZ00449
    Location:587 → 865
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:18 → 529
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:794 → 808
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1048 → 1303
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  2. XM_038653014.1 → XP_038508942.1  

    Conserved Domains (4) summary
    PTZ00449
    Location:598 → 876
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 540
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:805 → 819
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1059 → 1314
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  3. XM_038653017.1 → XP_038508945.1  

    Conserved Domains (4) summary
    PTZ00449
    Location:569 → 847
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 511
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:776 → 790
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1030 → 1285
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  4. XM_038653015.1 → XP_038508943.1  

    Conserved Domains (4) summary
    PTZ00449
    Location:594 → 872
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 536
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:801 → 815
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1055 → 1310
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  5. XM_038653018.1 → XP_038508946.1  

    Conserved Domains (4) summary
    PTZ00449
    Location:565 → 843
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 507
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:772 → 786
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1026 → 1281
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  6. XM_038653019.1 → XP_038508947.1  

    Conserved Domains (4) summary
    PTZ00449
    Location:307 → 585
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:64 → 249
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:514 → 528
    AF4_int; AF4 interaction motif
    pfam18876
    Location:768 → 1023
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  7. XM_038653020.1 → XP_038508948.1  

    Conserved Domains (4) summary
    PTZ00449
    Location:278 → 556
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:64 → 220
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:485 → 499
    AF4_int; AF4 interaction motif
    pfam18876
    Location:739 → 994
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

    Range
    117807028..118275870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038588490.1 → XP_038444418.1  AF4/FMR2 family member 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I3PGJ9
    Conserved Domains (4) summary
    PTZ00449
    Location:587 → 865
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:18 → 529
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:794 → 808
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1048 → 1303
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  2. XM_038588488.1 → XP_038444416.1  AF4/FMR2 family member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PGJ9
    Conserved Domains (4) summary
    PTZ00449
    Location:598 → 876
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 540
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:805 → 819
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1059 → 1314
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  3. XM_038588491.1 → XP_038444419.1  AF4/FMR2 family member 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I3PGT9
    Conserved Domains (4) summary
    PTZ00449
    Location:569 → 847
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 511
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:776 → 790
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1030 → 1285
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  4. XM_038588489.1 → XP_038444417.1  AF4/FMR2 family member 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PGJ9
    Conserved Domains (4) summary
    PTZ00449
    Location:594 → 872
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 536
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:801 → 815
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1055 → 1310
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  5. XM_038588492.1 → XP_038444420.1  AF4/FMR2 family member 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I3PGT9
    Conserved Domains (4) summary
    PTZ00449
    Location:565 → 843
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 507
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:772 → 786
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1026 → 1281
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  6. XM_038588493.1 → XP_038444421.1  AF4/FMR2 family member 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I3PCN3
    Conserved Domains (4) summary
    PTZ00449
    Location:307 → 585
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:64 → 249
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:514 → 528
    AF4_int; AF4 interaction motif
    pfam18876
    Location:768 → 1023
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  7. XM_038588494.1 → XP_038444422.1  AF4/FMR2 family member 2 isoform X7

    UniProtKB/TrEMBL
    A0A8I3PCN3
    Conserved Domains (4) summary
    PTZ00449
    Location:278 → 556
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:64 → 220
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:485 → 499
    AF4_int; AF4 interaction motif
    pfam18876
    Location:739 → 994
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    102589304..103060400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038464308.1 → XP_038320236.1  AF4/FMR2 family member 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I3PGJ9
    Conserved Domains (4) summary
    PTZ00449
    Location:587 → 865
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:18 → 529
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:794 → 808
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1048 → 1303
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  2. XM_038464306.1 → XP_038320234.1  AF4/FMR2 family member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PGJ9
    Conserved Domains (4) summary
    PTZ00449
    Location:598 → 876
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 540
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:805 → 819
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1059 → 1314
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  3. XM_038464309.1 → XP_038320237.1  AF4/FMR2 family member 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I3PGT9
    Conserved Domains (4) summary
    PTZ00449
    Location:569 → 847
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 511
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:776 → 790
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1030 → 1285
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  4. XM_038464307.1 → XP_038320235.1  AF4/FMR2 family member 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PGJ9
    Conserved Domains (4) summary
    PTZ00449
    Location:594 → 872
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 536
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:801 → 815
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1055 → 1310
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  5. XM_038464310.1 → XP_038320238.1  AF4/FMR2 family member 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I3PGT9
    Conserved Domains (4) summary
    PTZ00449
    Location:565 → 843
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:29 → 507
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:772 → 786
    AF4_int; AF4 interaction motif
    pfam18876
    Location:1026 → 1281
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  6. XM_038464311.1 → XP_038320239.1  AF4/FMR2 family member 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I3PCN3
    Conserved Domains (4) summary
    PTZ00449
    Location:307 → 585
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:64 → 249
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:514 → 528
    AF4_int; AF4 interaction motif
    pfam18876
    Location:768 → 1023
    AF-4_C; AF-4 proto-oncoprotein C-terminal region

  7. XM_038464312.1 → XP_038320240.1  AF4/FMR2 family member 2 isoform X7

    UniProtKB/TrEMBL
    A0A8I3PCN3
    Conserved Domains (4) summary
    PTZ00449
    Location:278 → 556
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam05110
    Location:64 → 220
    AF-4; AF-4 proto-oncoprotein
    pfam18875
    Location:485 → 499
    AF4_int; AF4 interaction motif
    pfam18876
    Location:739 → 994
    AF-4_C; AF-4 proto-oncoprotein C-terminal region
Nucleotide Protein
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