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PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 [ Canis lupus familiaris (dog) ]

Gene ID: 491903, updated on 25-Jul-2026
Official Symbol
PFKFB1provided by VGNC
Official Full Name
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1provided by VGNC
Primary source
VGNC:VGNC:44442
See related
Ensembl:ENSCAFG00845030216 RGD:12133957
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See PFKFB1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (46906002..46979845, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (37952977..38026831, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (46824607..46898459, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (46415757..46489624, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (46882333..46956196, complement)

Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene PEST proteolytic signal-containing nuclear protein-like Neighboring gene small nucleolar RNA SNORA11 Neighboring gene trophinin Neighboring gene small EDRK-rich factor 2-like Neighboring gene apurinic/apyrimidinic endodeoxyribonuclease 2 Neighboring gene 5'-aminolevulinate synthase 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 6-phosphofructo-2-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fructose-2,6-bisphosphate 2-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fructose 2,6-bisphosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fructose metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051843.1 Reference ROS_Cfam_1.0

    Range
    46906002..46979845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038450116.1 → XP_038306044.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KLU5
    Conserved Domains (2) summary
    pfam00300
    Location:211 → 397
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 208
    6PF2K; 6-phosphofructo-2-kinase

  2. XM_038450114.1 → XP_038306042.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KLU5
    Related
    ENSCAFP00845042197.1, ENSCAFT00845053700.1
    Conserved Domains (2) summary
    pfam00300
    Location:231 → 417
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:7 → 228
    6PF2K; 6-phosphofructo-2-kinase

  3. XM_038450115.1 → XP_038306043.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KLU5
    Conserved Domains (2) summary
    pfam00300
    Location:211 → 397
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 208
    6PF2K; 6-phosphofructo-2-kinase

  4. XM_038450118.1 → XP_038306046.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KN60, A0A8I3Q2Z4
    Conserved Domains (2) summary
    pfam00300
    Location:250 → 387
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 247
    6PF2K; 6-phosphofructo-2-kinase

  5. XM_038450113.1 → XP_038306041.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KN60, A0A8I3Q2Z4
    Related
    ENSCAFP00845042185.1, ENSCAFT00845053689.1
    Conserved Domains (2) summary
    pfam00300
    Location:250 → 436
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 247
    6PF2K; 6-phosphofructo-2-kinase

  6. XM_038450117.1 → XP_038306045.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KLU5
    Conserved Domains (2) summary
    pfam00300
    Location:211 → 397
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 208
    6PF2K; 6-phosphofructo-2-kinase

  7. XM_038450119.1 → XP_038306047.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I3Q5Z1
    Related
    ENSCAFP00845042167.1, ENSCAFT00845053665.1
    Conserved Domains (2) summary
    pfam00300
    Location:156 → 342
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    cl17190
    Location:2 → 153
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049299.1 Alternate UMICH_Zoey_3.1

    Range
    46415757..46489624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038523570.1 → XP_038379498.1  

    Conserved Domains (2) summary
    pfam00300
    Location:211 → 397
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 208
    6PF2K; 6-phosphofructo-2-kinase

  2. XM_038523568.1 → XP_038379496.1  

    Conserved Domains (2) summary
    pfam00300
    Location:231 → 417
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:7 → 228
    6PF2K; 6-phosphofructo-2-kinase

  3. XM_038523569.1 → XP_038379497.1  

    Conserved Domains (2) summary
    pfam00300
    Location:211 → 397
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 208
    6PF2K; 6-phosphofructo-2-kinase

  4. XM_038523572.1 → XP_038379500.1  

    Conserved Domains (2) summary
    pfam00300
    Location:250 → 387
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 247
    6PF2K; 6-phosphofructo-2-kinase

  5. XM_038523567.1 → XP_038379495.1  

    Conserved Domains (2) summary
    pfam00300
    Location:250 → 436
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 247
    6PF2K; 6-phosphofructo-2-kinase

  6. XM_038523571.1 → XP_038379499.1  

    Conserved Domains (2) summary
    pfam00300
    Location:211 → 397
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 208
    6PF2K; 6-phosphofructo-2-kinase

  7. XM_038523573.1 → XP_038379501.1  

    Conserved Domains (2) summary
    pfam00300
    Location:156 → 342
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    cl17190
    Location:2 → 153
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

    Range
    46882333..46956196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038652056.1 → XP_038507984.1  

    Conserved Domains (2) summary
    pfam00300
    Location:211 → 397
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 208
    6PF2K; 6-phosphofructo-2-kinase

  2. XM_038652054.1 → XP_038507982.1  

    Conserved Domains (2) summary
    pfam00300
    Location:231 → 417
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:7 → 228
    6PF2K; 6-phosphofructo-2-kinase

  3. XM_038652055.1 → XP_038507983.1  

    Conserved Domains (2) summary
    pfam00300
    Location:211 → 397
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 208
    6PF2K; 6-phosphofructo-2-kinase

  4. XM_038652058.1 → XP_038507986.1  

    Conserved Domains (2) summary
    pfam00300
    Location:250 → 387
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 247
    6PF2K; 6-phosphofructo-2-kinase

  5. XM_038652053.1 → XP_038507981.1  

    Conserved Domains (2) summary
    pfam00300
    Location:250 → 436
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 247
    6PF2K; 6-phosphofructo-2-kinase

  6. XM_038652057.1 → XP_038507985.1  

    Conserved Domains (2) summary
    pfam00300
    Location:211 → 397
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 208
    6PF2K; 6-phosphofructo-2-kinase

  7. XM_038652059.1 → XP_038507987.1  

    Conserved Domains (2) summary
    pfam00300
    Location:156 → 342
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    cl17190
    Location:2 → 153
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

    Range
    46824607..46898459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038587529.1 → XP_038443457.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KLU5
    Conserved Domains (2) summary
    pfam00300
    Location:211 → 397
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 208
    6PF2K; 6-phosphofructo-2-kinase

  2. XM_038587527.1 → XP_038443455.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KLU5
    Conserved Domains (2) summary
    pfam00300
    Location:231 → 417
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:7 → 228
    6PF2K; 6-phosphofructo-2-kinase

  3. XM_038587528.1 → XP_038443456.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KLU5
    Conserved Domains (2) summary
    pfam00300
    Location:211 → 397
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 208
    6PF2K; 6-phosphofructo-2-kinase

  4. XM_038587531.1 → XP_038443459.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KN60, A0A8I3Q2Z4
    Conserved Domains (2) summary
    pfam00300
    Location:250 → 387
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 247
    6PF2K; 6-phosphofructo-2-kinase

  5. XM_038587526.1 → XP_038443454.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KN60, A0A8I3Q2Z4
    Conserved Domains (2) summary
    pfam00300
    Location:250 → 436
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 247
    6PF2K; 6-phosphofructo-2-kinase

  6. XM_038587530.1 → XP_038443458.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KLU5
    Conserved Domains (2) summary
    pfam00300
    Location:211 → 397
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 208
    6PF2K; 6-phosphofructo-2-kinase

  7. XM_038587532.1 → XP_038443460.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I3Q5Z1
    Conserved Domains (2) summary
    pfam00300
    Location:156 → 342
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    cl17190
    Location:2 → 153
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    37952977..38026831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038464913.1 → XP_038320841.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KLU5
    Conserved Domains (2) summary
    pfam00300
    Location:211 → 397
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 208
    6PF2K; 6-phosphofructo-2-kinase

  2. XM_005641396.4 → XP_005641453.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KLU5
    Conserved Domains (2) summary
    pfam00300
    Location:231 → 417
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:7 → 228
    6PF2K; 6-phosphofructo-2-kinase

  3. XM_022415975.2 → XP_022271683.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KLU5
    Conserved Domains (2) summary
    pfam00300
    Location:211 → 397
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 208
    6PF2K; 6-phosphofructo-2-kinase

  4. XM_038464914.1 → XP_038320842.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KN60, A0A8I3Q2Z4
    Conserved Domains (2) summary
    pfam00300
    Location:250 → 387
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 247
    6PF2K; 6-phosphofructo-2-kinase

  5. XM_038464912.1 → XP_038320840.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KN60, A0A8I3Q2Z4
    Conserved Domains (2) summary
    pfam00300
    Location:250 → 436
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:26 → 247
    6PF2K; 6-phosphofructo-2-kinase

  6. XM_014111869.3 → XP_013967344.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KLU5
    Conserved Domains (2) summary
    pfam00300
    Location:211 → 397
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    pfam01591
    Location:1 → 208
    6PF2K; 6-phosphofructo-2-kinase

  7. XM_014111871.2 → XP_013967346.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I3Q5Z1
    Conserved Domains (2) summary
    pfam00300
    Location:156 → 342
    His_Phos_1; Histidine phosphatase superfamily (branch 1)
    cl17190
    Location:2 → 153
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
Nucleotide Protein
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