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NTN3 netrin 3 [ Homo sapiens (human) ]

Gene ID: 4917, updated on 24-Nov-2020

Summary

Official Symbol
NTN3provided by HGNC
Official Full Name
netrin 3provided by HGNC
Primary source
HGNC:HGNC:8030
See related
Ensembl:ENSG00000162068 MIM:602349
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NTN2L
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See NTN3 in Genome Data Viewer
Location:
16p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2471297..2474145)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2521500..2524146)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene tubulin epsilon and delta complex 2 Neighboring gene uncharacterized LOC729652 Neighboring gene microRNA 6768 Neighboring gene TBC1 domain family member 24 Neighboring gene ATPase H+ transporting V0 subunit c

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon guidance NAS
Non-traceable Author Statement
more info
PubMed 
dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
netrin-3
Names
Netrin-2, chicken, homolog of, like
netrin-2-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006181.3NP_006172.1  netrin-3 precursor

    See identical proteins and their annotated locations for NP_006172.1

    Status: VALIDATED

    Source sequence(s)
    AC106820, U86759
    Consensus CDS
    CCDS10469.1
    UniProtKB/Swiss-Prot
    O00634
    Related
    ENSP00000293973.1, ENST00000293973.2
    Conserved Domains (3) summary
    smart00136
    Location:34253
    LamNT; Laminin N-terminal domain (domain VI)
    cd00055
    Location:373422
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cl02512
    Location:456562
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2471297..2474145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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