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LRRC8A leucine rich repeat containing 8 VRAC subunit A [ Canis lupus familiaris (dog) ]

Gene ID: 491309, updated on 27-Jun-2026
Official Symbol
LRRC8Aprovided by VGNC
Official Full Name
leucine rich repeat containing 8 VRAC subunit Aprovided by VGNC
Primary source
VGNC:VGNC:42814
See related
Ensembl:ENSCAFG00845025448 RGD:12244726
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See LRRC8A in Genome Data Viewer
Location:
chromosome: 9
Exon count:
5
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (55653903..55681136, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (53928394..53955628, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (54820897..54848149, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (54414997..54442249, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (54727390..54754601, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene dolichol kinase Neighboring gene phytanoyl-CoA dioxygenase domain containing 1 Neighboring gene kynurenine aminotransferase 1 Neighboring gene SPOUT domain containing methyltransferase 1 Neighboring gene endonuclease G

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
volume-regulated anion channel subunit LRRC8A
Names
leucine rich repeat containing 8 family member A

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    55653903..55681136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038678355.1 → XP_038534283.1  volume-regulated anion channel subunit LRRC8A

    UniProtKB/TrEMBL
    A0A8C0LC31, A0A8I3PQW0, A0A8I3PV35
    Related
    ENSCAFP00845035233.1, ENSCAFT00845044958.1
    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

  2. XM_038678357.1 → XP_038534285.1  volume-regulated anion channel subunit LRRC8A

    UniProtKB/TrEMBL
    A0A8C0LC31, A0A8I3PQW0, A0A8I3PV35
    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

  3. XM_038678356.1 → XP_038534284.1  volume-regulated anion channel subunit LRRC8A

    UniProtKB/TrEMBL
    A0A8C0LC31, A0A8I3PQW0, A0A8I3PV35
    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

  4. XM_038678358.1 → XP_038534286.1  volume-regulated anion channel subunit LRRC8A

    UniProtKB/TrEMBL
    A0A8C0LC31, A0A8I3PQW0, A0A8I3PV35
    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    54414997..54442249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038487200.1 → XP_038343128.1  

    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

  2. XM_038487202.1 → XP_038343130.1  

    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

  3. XM_038487201.1 → XP_038343129.1  

    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

  4. XM_038487203.1 → XP_038343131.1  

    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    54727390..54754601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038613052.1 → XP_038468980.1  

    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

  2. XM_038613055.1 → XP_038468983.1  

    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

  3. XM_038613053.1 → XP_038468981.1  

    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

  4. XM_038613056.1 → XP_038468984.1  

    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    54820897..54848149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038549108.1 → XP_038405036.1  volume-regulated anion channel subunit LRRC8A

    UniProtKB/TrEMBL
    A0A8C0LC31, A0A8I3PQW0, A0A8I3PV35
    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

  2. XM_038549110.1 → XP_038405038.1  volume-regulated anion channel subunit LRRC8A

    UniProtKB/TrEMBL
    A0A8C0LC31, A0A8I3PQW0, A0A8I3PV35
    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

  3. XM_038549109.1 → XP_038405037.1  volume-regulated anion channel subunit LRRC8A

    UniProtKB/TrEMBL
    A0A8C0LC31, A0A8I3PQW0, A0A8I3PV35
    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

  4. XM_038549111.1 → XP_038405039.1  volume-regulated anion channel subunit LRRC8A

    UniProtKB/TrEMBL
    A0A8C0LC31, A0A8I3PQW0, A0A8I3PV35
    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    53928394..53955628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005625263.4 → XP_005625320.1  volume-regulated anion channel subunit LRRC8A

    See identical proteins and their annotated locations for XP_005625320.1

    UniProtKB/TrEMBL
    A0A8C0LC31, A0A8I3PQW0, A0A8I3PV35
    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

  2. XM_038617531.1 → XP_038473459.1  volume-regulated anion channel subunit LRRC8A

    UniProtKB/TrEMBL
    A0A8C0LC31, A0A8I3PQW0, A0A8I3PV35
    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

  3. XM_005625265.4 → XP_005625322.1  volume-regulated anion channel subunit LRRC8A

    See identical proteins and their annotated locations for XP_005625322.1

    UniProtKB/TrEMBL
    A0A8C0LC31, A0A8I3PQW0, A0A8I3PV35
    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8

  4. XM_548430.6 → XP_548430.2  volume-regulated anion channel subunit LRRC8A

    See identical proteins and their annotated locations for XP_548430.2

    UniProtKB/TrEMBL
    A0A8C0LC31, A0A8I3PQW0, A0A8I3PV35
    Conserved Domains (4) summary
    COG4886
    Location:568 → 780
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:546 → 568
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:379 → 713
    internalin_A; class 1 internalin InlA
    pfam12534
    Location:1 → 340
    Pannexin_like; Pannexin-like TM region of LRRC8
Nucleotide Protein
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