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ATP2B2 ATPase plasma membrane Ca2+ transporting 2 [ Homo sapiens (human) ]

Gene ID: 491, updated on 23-Sep-2017
Official Symbol
ATP2B2provided by HGNC
Official Full Name
ATPase plasma membrane Ca2+ transporting 2provided by HGNC
Primary source
HGNC:HGNC:815
See related
Ensembl:ENSG00000157087 MIM:108733; Vega:OTTHUMG00000128679
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PMCA2; PMCA2a; PMCA2i
Summary
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Orthologs
Location:
3p25.3
Exon count:
32
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (10324023..10707962, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (10365707..10733131, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ghrelin opposite strand/antisense RNA Neighboring gene ghrelin and obestatin prepropeptide Neighboring gene SEC13 homolog, nuclear pore and COPII coat complex component Neighboring gene microRNA 378b Neighboring gene microRNA 885 Neighboring gene ATP2B2 intronic transcript 2 Neighboring gene long intergenic non-protein coding RNA 606 Neighboring gene solute carrier family 6 member 11 Neighboring gene uncharacterized LOC105376950

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Deafness, autosomal recessive 12 Compare labs

NHGRI GWAS Catalog

Description
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.
NHGRI GWA Catalog
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
NHGRI GWA Catalog
  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Cardiac conduction, organism-specific biosystem (from REACTOME)
    Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
  • Ion homeostasis, organism-specific biosystem (from REACTOME)
    Ion homeostasis, organism-specific biosystemIon channel homeostasis in relation to cardiac conduction is described in this section (Couette et al. 2006, Bartos et al. 2015).
  • Ion transport by P-type ATPases, organism-specific biosystem (from REACTOME)
    Ion transport by P-type ATPases, organism-specific biosystemThe P-type ATPases (E1-E2 ATPases) are a large group of evolutionarily related ion pumps that are found in bacteria, archaea and eukaryotes. They are referred to as P-type ATPases because they catal...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Pancreatic secretion, organism-specific biosystem (from KEGG)
    Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Pancreatic secretion, conserved biosystem (from KEGG)
    Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Platelet calcium homeostasis, organism-specific biosystem (from REACTOME)
    Platelet calcium homeostasis, organism-specific biosystemCa2+ homeostasis is controlled by processes that elevate or counter the elevation of cytosolic Ca2+. During steady state conditions, cytoplasmic Ca2+ is reduced by the accumulation of Ca2+ in intrac...
  • Platelet homeostasis, organism-specific biosystem (from REACTOME)
    Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...
  • Reduction of cytosolic Ca++ levels, organism-specific biosystem (from REACTOME)
    Reduction of cytosolic Ca++ levels, organism-specific biosystemDuring steady state conditions, cytoplasmic [Ca2+] is reduced by the accumulation of Ca2+ in intracellular stores and Ca2+ extrusion.
  • Salivary secretion, organism-specific biosystem (from KEGG)
    Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Salivary secretion, conserved biosystem (from KEGG)
    Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
PDZ domain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
calcium-transporting ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
calcium-transporting ATPase activity NAS
Non-traceable Author Statement
more info
PubMed 
calcium-transporting ATPase activity TAS
Traceable Author Statement
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ATP hydrolysis coupled cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cardiac conduction TAS
Traceable Author Statement
more info
 
regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
transport NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
plasma membrane calcium-transporting ATPase 2
Names
ATPase, Ca++ transporting, plasma membrane 2
plasma membrane Ca(2+)-ATPase
plasma membrane Ca2+ pump 2
plasma membrane calcium ATPase
plasma membrane calcium pump
NP_001001331.1
NP_001674.2
XP_005265236.1
XP_006713238.1
XP_011532054.1
XP_016861970.1
XP_016861971.1
XP_016861972.1
XP_016861973.1
XP_016861974.1
XP_016861975.1
XP_016861976.1
XP_016861977.1
XP_016861978.1
XP_016861979.1
XP_016861980.1
XP_016861981.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012046.2 RefSeqGene

    Range
    207448..389009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001001331.3NP_001001331.1  plasma membrane calcium-transporting ATPase 2 isoform 1

    See identical proteins and their annotated locations for NP_001001331.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1), also known as WB.
    Source sequence(s)
    AB210008, AC022384, AK308898, S95738, X63575
    Consensus CDS
    CCDS33701.1
    UniProtKB/Swiss-Prot
    Q01814
    UniProtKB/TrEMBL
    A0A024R2K6, Q4J699, Q4LE63
    Related
    ENSP00000353414.2, ENST00000360273.6
    Conserved Domains (7) summary
    TIGR01517
    Location:121087
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:161488
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:9031081
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:51113
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:11261173
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:690829
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:549638
    Cation_ATPase; Cation transport ATPase (P-type)
  2. NM_001330611.2NP_001317540.1  plasma membrane calcium-transporting ATPase 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks three in-frame exons in the 5' coding region, and contains two additional exons in the 3' coding regions, resulting in novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC018839, AC022384, AC090841
    Consensus CDS
    CCDS82733.1
    UniProtKB/Swiss-Prot
    Q01814
  3. NM_001353564.1NP_001340493.1  plasma membrane calcium-transporting ATPase 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks three in-frame exons, compared to variant 1. The encoded isoform (2), also known as ZB, is shorter, compared to isoform 1. Variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AC022384, AC090841, BM681464, L20977
    Conserved Domains (2) summary
    pfam12424
    Location:10811127
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:121042
    E1-E2_ATPase; E1-E2 ATPase
  4. NM_001683.4NP_001674.2  plasma membrane calcium-transporting ATPase 2 isoform 2

    See identical proteins and their annotated locations for NP_001674.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three in-frame exons, compared to variant 1. The encoded isoform (2), also known as ZB, is shorter, compared to isoform 1. Variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AB210008, AC022384, AK308898, X63575
    Consensus CDS
    CCDS2601.1
    UniProtKB/Swiss-Prot
    Q01814
    UniProtKB/TrEMBL
    A0A024R2E4, Q4LE63
    Related
    ENSP00000373311.4, OTTHUMP00000178534, ENST00000383800.8
    Conserved Domains (2) summary
    pfam12424
    Location:10811127
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:121042
    E1-E2_ATPase; E1-E2 ATPase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

    Range
    10324023..10707962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006484.1XP_016861973.1  plasma membrane calcium-transporting ATPase 2 isoform X2

    UniProtKB/Swiss-Prot
    Q01814
    Conserved Domains (7) summary
    TIGR01517
    Location:121056
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:161457
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:8721050
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:51113
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:10951142
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:659798
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:518607
    Cation_ATPase; Cation transport ATPase (P-type)
  2. XM_006713175.3XP_006713238.1  plasma membrane calcium-transporting ATPase 2 isoform X1

    See identical proteins and their annotated locations for XP_006713238.1

    UniProtKB/Swiss-Prot
    Q01814
    UniProtKB/TrEMBL
    A0A024R2K6
    Conserved Domains (7) summary
    TIGR01517
    Location:121087
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:161488
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:9031081
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:51113
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:11261173
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:690829
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:549638
    Cation_ATPase; Cation transport ATPase (P-type)
  3. XM_017006487.1XP_016861976.1  plasma membrane calcium-transporting ATPase 2 isoform X5

    UniProtKB/TrEMBL
    A0A024R2E4, Q4LE63
    Related
    ENSP00000380267.1, OTTHUMP00000178537, ENST00000397077.5, OTTHUMT00000276089
    Conserved Domains (2) summary
    pfam12424
    Location:10811127
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:121042
    E1-E2_ATPase; E1-E2 ATPase
  4. XM_017006481.1XP_016861970.1  plasma membrane calcium-transporting ATPase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q01814
    UniProtKB/TrEMBL
    A0A024R2K6
    Conserved Domains (7) summary
    TIGR01517
    Location:121087
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:161488
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:9031081
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:51113
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:11261173
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:690829
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:549638
    Cation_ATPase; Cation transport ATPase (P-type)
  5. XM_005265179.4XP_005265236.1  plasma membrane calcium-transporting ATPase 2 isoform X1

    See identical proteins and their annotated locations for XP_005265236.1

    UniProtKB/Swiss-Prot
    Q01814
    UniProtKB/TrEMBL
    A0A024R2K6
    Conserved Domains (7) summary
    TIGR01517
    Location:121087
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:161488
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:9031081
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:51113
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:11261173
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:690829
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:549638
    Cation_ATPase; Cation transport ATPase (P-type)
  6. XM_011533752.2XP_011532054.1  plasma membrane calcium-transporting ATPase 2 isoform X1

    See identical proteins and their annotated locations for XP_011532054.1

    UniProtKB/Swiss-Prot
    Q01814
    UniProtKB/TrEMBL
    A0A024R2K6
    Related
    ENSP00000324172.5, OTTHUMP00000158863, ENST00000352432.8, OTTHUMT00000250576
    Conserved Domains (7) summary
    TIGR01517
    Location:121087
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:161488
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:9031081
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:51113
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:11261173
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:690829
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:549638
    Cation_ATPase; Cation transport ATPase (P-type)
  7. XM_017006485.1XP_016861974.1  plasma membrane calcium-transporting ATPase 2 isoform X3

    Conserved Domains (7) summary
    TIGR01517
    Location:121087
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:161488
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:9031081
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:51113
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:11261190
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:690829
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:549638
    Cation_ATPase; Cation transport ATPase (P-type)
  8. XM_017006486.1XP_016861975.1  plasma membrane calcium-transporting ATPase 2 isoform X4

    UniProtKB/Swiss-Prot
    Q01814
    Conserved Domains (7) summary
    TIGR01517
    Location:121087
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:161488
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:9031081
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:51113
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:11261190
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:690829
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:549638
    Cation_ATPase; Cation transport ATPase (P-type)
  9. XM_017006492.1XP_016861981.1  plasma membrane calcium-transporting ATPase 2 isoform X10

  10. XM_017006483.1XP_016861972.1  plasma membrane calcium-transporting ATPase 2 isoform X2

    UniProtKB/Swiss-Prot
    Q01814
    Related
    ENSP00000414854.1, OTTHUMP00000178535, ENST00000452124.1, OTTHUMT00000276087
    Conserved Domains (7) summary
    TIGR01517
    Location:121056
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:161457
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:8721050
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:51113
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:10951142
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:659798
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:518607
    Cation_ATPase; Cation transport ATPase (P-type)
  11. XM_017006482.1XP_016861971.1  plasma membrane calcium-transporting ATPase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q01814
    UniProtKB/TrEMBL
    A0A024R2K6
    Conserved Domains (7) summary
    TIGR01517
    Location:121087
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:161488
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:9031081
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:51113
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:11261173
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:690829
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:549638
    Cation_ATPase; Cation transport ATPase (P-type)
  12. XM_017006491.1XP_016861980.1  plasma membrane calcium-transporting ATPase 2 isoform X9

    Related
    ENSP00000424494.1, OTTHUMP00000222615, ENST00000460129.5, OTTHUMT00000276088
  13. XM_017006489.1XP_016861978.1  plasma membrane calcium-transporting ATPase 2 isoform X7

    UniProtKB/Swiss-Prot
    Q01814
  14. XM_017006490.1XP_016861979.1  plasma membrane calcium-transporting ATPase 2 isoform X8

  15. XM_017006488.1XP_016861977.1  plasma membrane calcium-transporting ATPase 2 isoform X6

    Conserved Domains (7) summary
    TIGR01517
    Location:121056
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:161457
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:8721050
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:51113
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:10951159
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:659798
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:518607
    Cation_ATPase; Cation transport ATPase (P-type)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    10315744..10497280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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