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NTF4 neurotrophin 4 [ Homo sapiens (human) ]

Gene ID: 4909, updated on 9-Oct-2021

Summary

Official Symbol
NTF4provided by HGNC
Official Full Name
neurotrophin 4provided by HGNC
Primary source
HGNC:HGNC:8024
See related
Ensembl:ENSG00000225950 MIM:162662
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NT4; NT5; NT-4; NT-5; NTF5; GLC10; GLC1O; NT-4/5
Summary
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 4.5), prostate (RPKM 2.1) and 6 other tissues See more
Orthologs
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Genomic context

See NTF4 in Genome Data Viewer
Location:
19q13.33
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49058284..49065076, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49564397..49567124, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene neurotrophin 4 pseudogene Neighboring gene chorionic gonadotropin subunit beta 7 Neighboring gene potassium voltage-gated channel subfamily A member 7 Neighboring gene RNA, 7SL, cytoplasmic 708, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of neurotrophin 4 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nerve growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in adult locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in epidermis development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in ganglion mother cell fate determination ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in innervation IEA
Inferred from Electronic Annotation
more info
 
involved_in long-term memory ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in mechanoreceptor differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in memory IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nerve development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nerve growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peripheral nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sensory organ boundary specification ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in taste bud development IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
neurotrophin-4
Names
neurotrophic factor 4
neurotrophic factor 5
neurotrophin 5 (neurotrophin 4/5)
neurotrophin-5
neutrophic factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016289.1 RefSeqGene

    Range
    5001..7728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001395489.1NP_001382418.1  neurotrophin-4 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC008687
    Conserved Domains (1) summary
    pfam00243
    Location:89208
    NGF; Nerve growth factor family
  2. NM_006179.5NP_006170.1  neurotrophin-4 preproprotein

    See identical proteins and their annotated locations for NP_006170.1

    Status: REVIEWED

    Source sequence(s)
    AC008687
    Consensus CDS
    CCDS12754.1
    UniProtKB/Swiss-Prot
    P34130
    UniProtKB/TrEMBL
    A0A024QZE4
    Related
    ENSP00000469455.1, ENST00000593537.1
    Conserved Domains (1) summary
    pfam00243
    Location:89208
    NGF; Nerve growth factor family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49058284..49065076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258962.3XP_005259019.1  neurotrophin-4 isoform X2

    UniProtKB/Swiss-Prot
    P34130
    UniProtKB/TrEMBL
    A0A024QZE4
    Conserved Domains (1) summary
    pfam00243
    Location:89208
    NGF; Nerve growth factor family
  2. XM_006723232.3XP_006723295.1  neurotrophin-4 isoform X2

    See identical proteins and their annotated locations for XP_006723295.1

    UniProtKB/Swiss-Prot
    P34130
    UniProtKB/TrEMBL
    A0A024QZE4
    Conserved Domains (1) summary
    pfam00243
    Location:89208
    NGF; Nerve growth factor family
  3. XM_011527009.2XP_011525311.1  neurotrophin-4 isoform X2

    See identical proteins and their annotated locations for XP_011525311.1

    UniProtKB/Swiss-Prot
    P34130
    UniProtKB/TrEMBL
    A0A024QZE4
    Conserved Domains (1) summary
    pfam00243
    Location:89208
    NGF; Nerve growth factor family
  4. XM_011527010.2XP_011525312.1  neurotrophin-4 isoform X2

    See identical proteins and their annotated locations for XP_011525312.1

    UniProtKB/Swiss-Prot
    P34130
    UniProtKB/TrEMBL
    A0A024QZE4
    Conserved Domains (1) summary
    pfam00243
    Location:89208
    NGF; Nerve growth factor family
  5. XM_011527008.2XP_011525310.1  neurotrophin-4 isoform X1

    Conserved Domains (1) summary
    pfam00243
    Location:99217
    NGF; Nerve growth factor family

RNA

  1. XR_001753693.1 RNA Sequence

  2. XR_001753694.1 RNA Sequence

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