NTF4 neurotrophin 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NTF4provided by HGNC
Official Full Name: neurotrophin 4provided by HGNC
Primary source: HGNC:HGNC:8024
See related: Ensembl:ENSG00000225950 MIM:162662; AllianceGenome:HGNC:8024
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NT4; NT5; NT-4; NT-5; NTF5; GLC10; GLC1O; NT-4/5
Summary: This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]
Expression: Biased expression in skin (RPKM 4.5), prostate (RPKM 2.1) and 6 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.33

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (49058284..49065035, complement)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (52053068..52059823, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (49564385..49568292, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-cell transcriptome and cell-specific network analysis reveal the reparative effect of neurotrophin-4 in preantral follicles grown in vitro.
Title: Single-cell transcriptome and cell-specific network analysis reveal the reparative effect of neurotrophin-4 in preantral follicles grown in vitro.
NTF4 stimulates the progression of gastric cancer via regulating FOXL1.
Title: NTF4 stimulates the progression of gastric cancer via regulating FOXL1.
The Impact of Physical Exercise on the Circulating Levels of BDNF and NT 4/5: A Review.
Title: The Impact of Physical Exercise on the Circulating Levels of BDNF and NT 4/5: A Review.
NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats.
Title: NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats.
Upregulated NTF4 in colorectal cancer promotes tumor development via regulating autophagy.
Title: Upregulated NTF4 in colorectal cancer promotes tumor development via regulating autophagy.
Meta-analysis found the levels of both NT-3 and NT-4/5 were significantly increased in bipolar disorder patients. Through subgroup analysis, this increase persisted only in patients in depressed state, but not in manic or euthymic state. In addition, we found the differences in NT-3 and NT-4/5 were significantly associated with the duration of illness, but not by the mean age or female proportion.
Title: State-dependent increase in the levels of neurotrophin-3 and neurotrophin-4/5 in patients with bipolar disorder: A meta-analysis.
Elevated intra-amniotic levels of docosahexaenoic acid and arachidonic acid in the mid-trimester are correlated with increased NT4 concentrations.
Title: Association between neurotrophin 4 and long-chain polyunsaturated fatty acid levels in mid-trimester amniotic fluid.
No differences in plasma BDNF, NGF, NT3, NT4 and GDNF were found between autism spectrum disorders and control.
Title: Circulating levels of neurotrophic factors in autism spectrum disorders.
Patients with mastocytosis featured elevated serum levels of NGF, NT-3, and NT-4. TrkA, TrkB, and TrkC expression was also elevated.
Title: Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis.
The NTF4 variants p.Gly157Ala and p.Ala182Val have been shown to be functional mutations, occurring in 2 of a total of 720 Chinese primary open-angle glaucoma patients.
Title: Evaluation of NTF4 as a causative gene for primary open-angle glaucoma.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Glaucoma 1, open angle, O MedGen: C2751294 OMIM: 613100 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	The gene expression of neurotrophin 4 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D19S1129 (e-PCR)
- UniSTS:10256

RH46960 (e-PCR)
- UniSTS:52320

RH80807 (e-PCR)
- UniSTS:91638

Homology

Homologs of the NTF4 gene: The NTF4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and frog.
Orthologs from Annotation Pipeline: 220 organisms have orthologs with human gene NTF4
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables nerve growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in epidermis development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in ganglion mother cell fate determination	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in innervation	IEA Inferred from Electronic Annotation more info
involved_in long-term memory	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mechanoreceptor differentiation	IEA Inferred from Electronic Annotation more info
involved_in memory	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in nerve development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in nerve growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in sensory organ boundary specification	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in taste bud development	IEA Inferred from Electronic Annotation more info
involved_in transmembrane receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: neurotrophin-4

Names: neurotrophic factor 4; neurotrophic factor 5; neurotrophin 5 (neurotrophin 4/5); neurotrophin-5; neutrophic factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016289.2 RefSeqGene

Range

5217..8907

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001395489.1 → NP_001382418.1 neurotrophin-4 preproprotein

Status: REVIEWED

Source sequence(s)

AC008687

Consensus CDS

CCDS12754.1

UniProtKB/Swiss-Prot

Q6FH56

UniProtKB/TrEMBL

A0A024QZE4

Related

ENSP00000512388.1, ENST00000696091.1

Conserved Domains (1) summary

pfam00243
Location:89 → 208

NGF; Nerve growth factor family
NM_006179.5 → NP_006170.1 neurotrophin-4 preproprotein

See identical proteins and their annotated locations for NP_006170.1

Status: REVIEWED

Source sequence(s)

AC008687

Consensus CDS

CCDS12754.1

UniProtKB/Swiss-Prot

P34130, Q6FH56

UniProtKB/TrEMBL

A0A024QZE4

Related

ENSP00000469455.1, ENST00000593537.2

Conserved Domains (1) summary

pfam00243
Location:89 → 208

NGF; Nerve growth factor family