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epsilonTry epsilonTrypsin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 49080, updated on 6-Jul-2026
Official Symbol
epsilonTryprovided by FlyBase
Official Full Name
epsilonTrypsinprovided by FlyBase
Primary source
FLYBASE:FBgn0010425
Locus tag
Dmel_CG18681
See related
AllianceGenome:FB:FBgn0010425
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18681; Dmel\CG18681; DmEpsilonTry; epsilon; epsilonTrp; EpsilonTry; SP88; Try
Summary
Enables serine hydrolase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A1 and prostate cancer. Orthologous to several human genes including KLK12 (kallikrein related peptidase 12); KLK4 (kallikrein related peptidase 4); and KLK9 (kallikrein related peptidase 9). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See epsilonTry in Genome Data Viewer
Location:
47F4-47F4; 2-64 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11345237..11346066, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7232742..7233571, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene thetaTrypsin Neighboring gene alphaTrypsin Neighboring gene betaTrypsin Neighboring gene gammaTrypsin

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Study on the material basis and mechanism of Hemerocallis citrina Baroni on sleep-improvement using Drosophila activity monitoring, metabolomic, targeted screening and transcriptomic. Liang Y, et al. Food Res Int, 2023 Oct. PMID 37689837
  2. The Putzig-NURF nucleosome remodeling complex is required for ecdysone receptor signaling and innate immunity in Drosophila melanogaster. Kugler SJ, et al. Genetics, 2011 May. PMID 21385730, Free PMC Article
  3. In Drosophila Hemolymph, Serine Proteases Are the Major Gelatinases and Caseinases. Gatti JL, et al. Insects, 2024 Mar 28. PMID 38667364, Free PMC Article
  4. Concerted evolution within a trypsin gene cluster in Drosophila. Wang S, et al. Mol Biol Evol, 1999 Sep. PMID 10486967
  5. A novel interplay between the ubiquitin–proteasome system and serine proteases during Drosophila development. Lipinszki Z, et al. Biochem J, 2013 Sep 15. PMID 23805892

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine hydrolase activity HDA PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
epsilonTrypsin
Names
CG18681-PA
epsilonTry-PA
NP_525112.1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11345237..11346066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080373.3 → NP_525112.1  epsilonTrypsin

    See identical proteins and their annotated locations for NP_525112.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35005, Q6IDF4, Q9V5Y1
    Related
    FBpp0087256
    Conserved Domains (2) summary
    smart00020
    Location:30 → 249
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:31 → 252
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35005.1 P35005

Gene LinkOut

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