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NTF3 neurotrophin 3 [ Homo sapiens (human) ]

Gene ID: 4908, updated on 17-Oct-2021

Summary

Official Symbol
NTF3provided by HGNC
Official Full Name
neurotrophin 3provided by HGNC
Primary source
HGNC:HGNC:8023
See related
Ensembl:ENSG00000185652 MIM:162660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NT3; HDNF; NGF2; NT-3; NGF-2
Summary
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
Expression
Broad expression in ovary (RPKM 4.8), spleen (RPKM 2.1) and 19 other tissues See more
Orthologs
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Genomic context

See NTF3 in Genome Data Viewer
Location:
12p13.31
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (5432108..5495299)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (5541274..5604465)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369617 Neighboring gene 12p13 proximal LINE-mediated recombination region Neighboring gene uncharacterized LOC105369618 Neighboring gene dynein light chain roadblock-type 1 pseudogene Neighboring gene meiotic recombination hotspot F Neighboring gene anoctamin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129711

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chemoattractant activity IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nerve growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of activation of protein kinase B activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in induction of positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in memory IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nerve development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nerve growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peripheral nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
neurotrophin-3
Names
nerve growth factor 2
neurotrophic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050629.1 RefSeqGene

    Range
    4995..68186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001102654.2NP_001096124.1  neurotrophin-3 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001096124.1

    Status: REVIEWED

    Source sequence(s)
    AC007848, BC069773, BU939830, CD672441, CN267386
    Consensus CDS
    CCDS44806.1
    UniProtKB/Swiss-Prot
    P20783
    Related
    ENSP00000397297.2, ENST00000423158.4
    Conserved Domains (1) summary
    pfam00243
    Location:157266
    NGF; Nerve growth factor family
  2. NM_002527.5NP_002518.1  neurotrophin-3 isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_002518.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence and uses a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC069773, CD672441
    Consensus CDS
    CCDS8538.1
    UniProtKB/Swiss-Prot
    P20783
    Related
    ENSP00000328738.6, ENST00000331010.7
    Conserved Domains (1) summary
    pfam00243
    Location:144253
    NGF; Nerve growth factor family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    5432108..5495299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520963.2XP_011519265.1  neurotrophin-3 isoform X1

    See identical proteins and their annotated locations for XP_011519265.1

    UniProtKB/Swiss-Prot
    P20783
    Conserved Domains (1) summary
    pfam00243
    Location:144253
    NGF; Nerve growth factor family
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