NTF3 neurotrophin 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NTF3provided by HGNC
Official Full Name: neurotrophin 3provided by HGNC
Primary source: HGNC:HGNC:8023
See related: Ensembl:ENSG00000185652 MIM:162660
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NT3; HDNF; NGF2; NT-3; NGF-2
Summary: The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
Expression: Broad expression in ovary (RPKM 4.8), spleen (RPKM 2.1) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12p13.31

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109.20210514	current	GRCh38.p13 (GCF_000001405.39)	12	NC_000012.12 (5432108..5495299)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (5541274..5604465)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue.
Title: Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue.
The Role of the Second Extracellular Loop of Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T Cells: A Peripheral Biomarker in the Etiology of Schizophrenia.
Title: The Role of the Second Extracellular Loop of Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T Cells: A Peripheral Biomarker in the Etiology of Schizophrenia.
Neurotrophin 3 ligand-coated with silver nanoparticle was induced in the model to normalize the transcription of myelin gene
Title: Silver nanoparticles conjugated with Neurotrophin 3 upregulate myelin gene transcription pathway.
In patients with schizophrenia, serum levels of neurotrophin-3 are increased only if depressive symptoms are also present.
Title: In schizophrenia serum level of neurotrophin-3 (NT-3) is increased only if depressive symptoms are present.
NTF3 is a novel target gene of POU3F2 and that the POU3F2/NTF3 pathway plays a role in the process of neuronal differentiation.
Title: NTF3 Is a Novel Target Gene of the Transcription Factor POU3F2 and Is Required for Neuronal Differentiation.
brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) levels in post-mortem brain tissue from patients with depression compared to healthy individuals - a proof of concept study
Title: Brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) levels in post-mortem brain tissue from patients with depression compared to healthy individuals - a proof of concept study.
NT-3 has been shown to be both an osteogenic and angiogenic factor, and can also enhance expression of the key osteogenic factor, BMP-2, as well as the major angiogenic factor, VEGF, to promote bone formation, vascularization, and bone healing
Title: Roles of neurotrophins in skeletal tissue formation and healing.
High expression of NT-3 is associated with glioblastoma.
Title: Autophagy and TrkC/NT-3 signaling joined forces boost the hypoxic glioblastoma cell survival.
Meta-analysis found the levels of both NT-3 and NT-4/5 were significantly increased in bipolar disorder patients. Through subgroup analysis, this increase persisted only in patients in depressed state, but not in manic or euthymic state. In addition, we found the differences in NT-3 and NT-4/5 were significantly associated with the duration of illness, but not by the mean age or female proportion.
Title: State-dependent increase in the levels of neurotrophin-3 and neurotrophin-4/5 in patients with bipolar disorder: A meta-analysis.
NT3 upregulates cellular proliferation, extracellular matrix protein production, and collagen deposition in human aortic valve interstitial cells through the Trk-Akt-cyclin D1 cascade.
Title: Neurotrophin 3 upregulates proliferation and collagen production in human aortic valve interstitial cells: a potential role in aortic valve sclerosis.

Submit: New GeneRIF Correction See all GeneRIFs (75)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:483844

UniSTS:225313 (e-PCR)
- UniSTS:225313

GDB:214846 (e-PCR)
- UniSTS:156195

RH48860 (e-PCR)
- UniSTS:58174

D12S99 (e-PCR), detects polymorphism
- UniSTS:48707

G42645 (e-PCR)
- UniSTS:94545

SHGC-149817 (e-PCR)
- UniSTS:177240

D12S99 (e-PCR), detects polymorphism
- UniSTS:52654

G19257 (e-PCR)
- UniSTS:19909

SHGC-943 (e-PCR)
- UniSTS:173266

GDB:210011 (e-PCR)
- UniSTS:156125

Ntf3 (e-PCR), detects polymorphism
- UniSTS:507105

SHGC-142535 (e-PCR)
- UniSTS:171515

Homology

Homologs of the NTF3 gene: The NTF3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 421 organisms have orthologs with human gene NTF3
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chemoattractant activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables nerve growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of activation of protein kinase B activity	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in induction of positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in memory	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in nerve development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in nerve growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in peripheral nervous system development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of actin cytoskeleton reorganization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor internalization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in transmembrane receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in transmembrane receptor protein tyrosine kinase signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: neurotrophin-3

Names: nerve growth factor 2; neurotrophic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_050629.1 RefSeqGene

Range

4995..68186

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001102654.2 → NP_001096124.1 neurotrophin-3 isoform 1 preproprotein

See identical proteins and their annotated locations for NP_001096124.1

Status: REVIEWED

Source sequence(s)

AC007848, BC069773, BU939830, CD672441, CN267386

Consensus CDS

CCDS44806.1

UniProtKB/Swiss-Prot

P20783

Related

ENSP00000397297.2, ENST00000423158.4

Conserved Domains (1) summary

pfam00243
Location:157 → 266

NGF; Nerve growth factor family
NM_002527.5 → NP_002518.1 neurotrophin-3 isoform 2 preproprotein

See identical proteins and their annotated locations for NP_002518.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' sequence and uses a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

BC069773, CD672441

Consensus CDS

CCDS8538.1

UniProtKB/Swiss-Prot

P20783

Related

ENSP00000328738.6, ENST00000331010.7

Conserved Domains (1) summary

pfam00243
Location:144 → 253

NGF; Nerve growth factor family