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NTF3 neurotrophin 3 [ Homo sapiens (human) ]

Gene ID: 4908, updated on 9-Jun-2025
Official Symbol
NTF3provided by HGNC
Official Full Name
neurotrophin 3provided by HGNC
Primary source
HGNC:HGNC:8023
See related
Ensembl:ENSG00000185652 MIM:162660; AllianceGenome:HGNC:8023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NT3; HDNF; NGF2; NT-3; NGF-2
Summary
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
Expression
Broad expression in ovary (RPKM 4.8), spleen (RPKM 2.1) and 19 other tissues See more
Orthologs
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See NTF3 in Genome Data Viewer
Location:
12p13.31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (5430332..5495299)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (5437400..5502089)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (5541274..5604465)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369617 Neighboring gene Sharpr-MPRA regulatory region 8722 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:5355081-5355848 Neighboring gene long intergenic non-protein coding RNA 2443 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:5377405-5378062 Neighboring gene 12p13 proximal LINE-mediated recombination region Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:5399277-5399846 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:5399847-5400415 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:5497373-5498572 Neighboring gene uncharacterized LOC105369618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:5542091-5542616 Neighboring gene uncharacterized LOC124902865 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:5618629-5619828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:5626075-5626631 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:5629720-5630919 Neighboring gene OCT4 hESC enhancer GRCh37_chr12:5681388-5681889 Neighboring gene dynein light chain roadblock-type 1 pseudogene Neighboring gene anoctamin 2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC129711

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chemoattractant activity IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables nerve growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neurotrophin receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in induction of positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nerve development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nerve growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
neurotrophin-3
Names
nerve growth factor 2
neurotrophic factor

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050629.1 RefSeqGene

    Range
    4995..68186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001102654.2NP_001096124.1  neurotrophin-3 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001096124.1

    Status: REVIEWED

    Source sequence(s)
    AC007848, BC069773, BU939830, CD672441, CN267386
    Consensus CDS
    CCDS44806.1
    UniProtKB/Swiss-Prot
    P20783
    Related
    ENSP00000397297.2, ENST00000423158.4
    Conserved Domains (1) summary
    pfam00243
    Location:157266
    NGF; Nerve growth factor family
  2. NM_002527.5NP_002518.1  neurotrophin-3 isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_002518.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence and uses a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC069773, CD672441
    Consensus CDS
    CCDS8538.1
    UniProtKB/Swiss-Prot
    B7Z1T5, P20783, Q6FH50
    Related
    ENSP00000328738.6, ENST00000331010.7
    Conserved Domains (1) summary
    pfam00243
    Location:144253
    NGF; Nerve growth factor family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    5430332..5495299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428901.1XP_047284857.1  neurotrophin-3 isoform X1

    UniProtKB/Swiss-Prot
    B7Z1T5, P20783, Q6FH50
  2. XM_011520963.3XP_011519265.1  neurotrophin-3 isoform X1

    See identical proteins and their annotated locations for XP_011519265.1

    UniProtKB/Swiss-Prot
    B7Z1T5, P20783, Q6FH50
    Conserved Domains (1) summary
    pfam00243
    Location:144253
    NGF; Nerve growth factor family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    5437400..5502089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372132.1XP_054228107.1  neurotrophin-3 isoform X1

    UniProtKB/Swiss-Prot
    B7Z1T5, P20783, Q6FH50
  2. XM_054372133.1XP_054228108.1  neurotrophin-3 isoform X1

    UniProtKB/Swiss-Prot
    B7Z1T5, P20783, Q6FH50