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SIX4 SIX homeobox 4 [ Canis lupus familiaris (dog) ]

Gene ID: 490720, updated on 27-Jun-2026
Official Symbol
SIX4provided by VGNC
Official Full Name
SIX homeobox 4provided by VGNC
Primary source
VGNC:VGNC:46192
See related
Ensembl:ENSCAFG00845022621 RGD:12164361
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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See SIX4 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
3
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (35969183..35982082, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (35489928..35502823, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (36020222..36033117, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (35581305..35594193, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (35658978..35671679, complement)

Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Neighboring gene SIX homeobox 1 Neighboring gene MNAT1 component of CDK activating kinase Neighboring gene 10 kDa heat shock protein, mitochondrial Neighboring gene U6 spliceosomal RNA

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
homeobox protein SIX4
Names
sine oculis homeobox homolog 4
XP_038464913.1

Length

  • 785

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051812.1 Reference ROS_Cfam_1.0

    Range
    35969183..35982082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038673789.1 → XP_038529717.1  homeobox protein SIX4

    UniProtKB/TrEMBL
    A0A8C0K6T0, A0A8I3PG75
    Related
    ENSCAFP00845031338.1, ENSCAFT00845040020.1
    Conserved Domains (3) summary
    cd00086
    Location:233 → 287
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    NF033176
    Location:341 → 563
    auto_AIDA-I; autotransporter adhesin AIDA-I
    pfam16878
    Location:113 → 222
    SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049268.1 Alternate UMICH_Zoey_3.1

    Range
    35581305..35594193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038483408.1 → XP_038339336.1  

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

    Range
    35658978..35671679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038608985.1 → XP_038464913.1  

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

    Range
    36020222..36033117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038544872.1 → XP_038400800.1  homeobox protein SIX4

    UniProtKB/TrEMBL
    A0A8C0K2F9, A0A8C0K6T0

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    35489928..35502823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_547842.7 → XP_547842.2  homeobox protein SIX4

    See identical proteins and their annotated locations for XP_547842.2

    UniProtKB/TrEMBL
    A0A8C0K2F9, A0A8C0K6T0
    Conserved Domains (2) summary
    cd00086
    Location:232 → 286
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam16878
    Location:112 → 221
    SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain
Nucleotide Protein
Heading Accession and Version

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