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NT5E 5'-nucleotidase ecto [ Homo sapiens (human) ]

Gene ID: 4907, updated on 5-Jul-2020

Summary

Official Symbol
NT5Eprovided by HGNC
Official Full Name
5'-nucleotidase ectoprovided by HGNC
Primary source
HGNC:HGNC:8021
See related
Ensembl:ENSG00000135318 MIM:129190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NT; eN; NT5; NTE; eNT; CD73; E5NT; CALJA
Summary
The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Expression
Ubiquitous expression in endometrium (RPKM 30.0), ovary (RPKM 19.6) and 22 other tissues See more
Orthologs

Genomic context

See NT5E in Genome Data Viewer
Location:
6q14.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (85449584..85495791)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (86159302..86205509)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene tumor protein, translationally-controlled 1 pseudogene 6 Neighboring gene deoxyuridine triphosphatase pseudogene 5 Neighboring gene sorting nexin 14 Neighboring gene synaptotagmin binding cytoplasmic RNA interacting protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Calcification of joints and arteries
MedGen: C1859372 OMIM: 211800 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of 5'-nucleotidase, ecto (NT5E, CD73) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
AMP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA metabolic process TAS
Traceable Author Statement
more info
PubMed 
NAD metabolic process TAS
Traceable Author Statement
more info
 
adenosine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
leukocyte cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
purine nucleotide catabolic process TAS
Traceable Author Statement
more info
 
pyrimidine nucleoside catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface HDA PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
5'-nucleotidase
Names
5'-NT
Purine 5-Prime-Nucleotidase
ecto-5'-nucleotidase
NP_001191742.1
NP_002517.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028214.1 RefSeqGene

    Range
    5500..51201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204813.1NP_001191742.1  5'-nucleotidase isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001191742.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK075008, BC065937, BQ019358, DA574510, X55740
    Consensus CDS
    CCDS56439.1
    UniProtKB/Swiss-Prot
    P21589
    UniProtKB/TrEMBL
    Q6NZX3
    Related
    ENSP00000358665.3, ENST00000369651.7
    Conserved Domains (3) summary
    COG0737
    Location:11482
    UshA; 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family [Nucleotide transport and metabolism, Defense mechanisms]
    cd07409
    Location:29310
    MPP_CD73_N; CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain
    pfam02872
    Location:339457
    5_nucleotid_C; 5'-nucleotidase, C-terminal domain
  2. NM_002526.4NP_002517.1  5'-nucleotidase isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_002517.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK075008, BC065937, BQ019358, DA574510, X55740
    Consensus CDS
    CCDS5002.1
    UniProtKB/Swiss-Prot
    P21589
    UniProtKB/TrEMBL
    Q6NZX3
    Related
    ENSP00000257770.3, ENST00000257770.8
    Conserved Domains (3) summary
    COG0737
    Location:11532
    UshA; 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family [Nucleotide transport and metabolism, Defense mechanisms]
    cd07409
    Location:29310
    MPP_CD73_N; CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain
    pfam02872
    Location:339507
    5_nucleotid_C; 5'-nucleotidase, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    85449584..85495791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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