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RNF125 ring finger protein 125 [ Canis lupus familiaris (dog) ]

Gene ID: 490498, updated on 27-Jun-2026
Official Symbol
RNF125provided by VGNC
Official Full Name
ring finger protein 125provided by VGNC
Primary source
VGNC:VGNC:45627
See related
Ensembl:ENSCAFG00845010018 RGD:12061229
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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See RNF125 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
6
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (57552615..57589372, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (57004743..57041487, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (57544766..57581517, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (57229577..57266076, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (57248867..57285615, complement)

Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 138 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC119876454 Neighboring gene trafficking protein particle complex subunit 8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
E3 ubiquitin-protein ligase RNF125
XP_005622984.2
XP_038338087.1
XP_038338088.1
XP_038399519.1
XP_038399520.1
XP_038463640.1
XP_038463641.1
XP_038528321.1
XP_038528322.1
XP_547620.4

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051811.1 Reference ROS_Cfam_1.0

    Range
    57552615..57589372 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038672394.1 → XP_038528322.1  E3 ubiquitin-protein ligase RNF125 isoform X2

    Conserved Domains (4) summary
    cd00162
    Location:37 → 75
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam05605
    Location:141 → 168
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam18574
    Location:94 → 126
    zf_C2HC_14; C2HC Zing finger domain
    cl17238
    Location:35 → 76
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_038672393.1 → XP_038528321.1  E3 ubiquitin-protein ligase RNF125 isoform X1

    UniProtKB/TrEMBL
    A0A8I3N8R2
    Related
    ENSCAFP00845013728.1, ENSCAFT00845017631.1
    Conserved Domains (3) summary
    cd16542
    Location:35 → 76
    RING-HC_RNF125; RING finger, HC subclass, found in RING finger protein 125 (RNF125)
    pfam05605
    Location:141 → 173
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam18574
    Location:94 → 126
    zf_C2HC_14; C2HC Zing finger domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049267.1 Alternate UMICH_Zoey_3.1

    Range
    57229577..57266076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038482160.1 → XP_038338088.1  

    Conserved Domains (4) summary
    cd00162
    Location:37 → 75
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam05605
    Location:141 → 168
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam18574
    Location:94 → 126
    zf_C2HC_14; C2HC Zing finger domain
    cl17238
    Location:35 → 76
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_038482159.1 → XP_038338087.1  

    Conserved Domains (3) summary
    cd16542
    Location:35 → 76
    RING-HC_RNF125; RING finger, HC subclass, found in RING finger protein 125 (RNF125)
    pfam05605
    Location:141 → 173
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam18574
    Location:94 → 126
    zf_C2HC_14; C2HC Zing finger domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

    Range
    57248867..57285615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038607713.1 → XP_038463641.1  

    Conserved Domains (4) summary
    cd00162
    Location:37 → 75
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam05605
    Location:141 → 168
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam18574
    Location:94 → 126
    zf_C2HC_14; C2HC Zing finger domain
    cl17238
    Location:35 → 76
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_038607712.1 → XP_038463640.1  

    Conserved Domains (3) summary
    cd16542
    Location:35 → 76
    RING-HC_RNF125; RING finger, HC subclass, found in RING finger protein 125 (RNF125)
    pfam05605
    Location:141 → 173
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam18574
    Location:94 → 126
    zf_C2HC_14; C2HC Zing finger domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

    Range
    57544766..57581517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038543592.1 → XP_038399520.1  E3 ubiquitin-protein ligase RNF125 isoform X2

    Conserved Domains (4) summary
    cd00162
    Location:37 → 75
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam05605
    Location:141 → 168
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam18574
    Location:94 → 126
    zf_C2HC_14; C2HC Zing finger domain
    cl17238
    Location:35 → 76
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_038543591.1 → XP_038399519.1  E3 ubiquitin-protein ligase RNF125 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KGS5
    Conserved Domains (3) summary
    cd16542
    Location:35 → 76
    RING-HC_RNF125; RING finger, HC subclass, found in RING finger protein 125 (RNF125)
    pfam05605
    Location:141 → 173
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam18574
    Location:94 → 126
    zf_C2HC_14; C2HC Zing finger domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    57004743..57041487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005622927.4 → XP_005622984.2  E3 ubiquitin-protein ligase RNF125 isoform X2

    Conserved Domains (4) summary
    cd00162
    Location:37 → 75
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam05605
    Location:141 → 168
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam18574
    Location:94 → 126
    zf_C2HC_14; C2HC Zing finger domain
    cl17238
    Location:35 → 76
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_547620.7 → XP_547620.4  E3 ubiquitin-protein ligase RNF125 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KGS5
    Conserved Domains (3) summary
    cd16542
    Location:35 → 76
    RING-HC_RNF125; RING finger, HC subclass, found in RING finger protein 125 (RNF125)
    pfam05605
    Location:141 → 173
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam18574
    Location:94 → 126
    zf_C2HC_14; C2HC Zing finger domain
Nucleotide Protein
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