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PKLR pyruvate kinase L/R [ Canis lupus familiaris (dog) ]

Gene ID: 490425, updated on 12-Jan-2019

Summary

Official Symbol
PKLRprovided by VGNC
Official Full Name
pyruvate kinase L/Rprovided by VGNC
Primary source
VGNC:VGNC:44609
See related
Ensembl:ENSCAFG00000016959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs

Genomic context

See PKLR in Genome Data Viewer
Location:
chromosome: 7
Exon count:
14
Annotation release Status Assembly Chr Location
105 current CanFam3.1 (GCF_000002285.3) 7 NC_006589.3 (42263899..42272770)

Chromosome 7 - NC_006589.3Genomic Context describing neighboring genes Neighboring gene RUN and SH3 domain containing 1 Neighboring gene farnesyl diphosphate synthase Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium channel 3 Neighboring gene CDC like kinase 2 Neighboring gene secretory carrier membrane protein 3

Genomic regions, transcripts, and products

Genomic Sequence:
NC_006589.3 Chromosome 7 Reference CanFam3.1 Primary Assembly

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
potassium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
glycolytic process IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pyruvate kinase PKLR
Names
Pyruvate kinase isozyme R
Pyruvate kinase isozymes R/L
pyruvate kinase isozymes L/R
pyruvate kinase, liver and RBC
NP_001242947.1
NP_001243191.1
XP_013970455.1
XP_022276471.1
XP_022276472.1
XP_022276473.1
XP_022276474.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256018.1NP_001242947.1  pyruvate kinase PKLR isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a distinct and shorter N-terminus, as compared to isoform 1. Isoform 2 is also known as type L.
    Source sequence(s)
    AH004600, DN338485
    UniProtKB/Swiss-Prot
    Q29536
    Conserved Domains (2) summary
    cd00288
    Location:54542
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:55539
    pyruv_kin; pyruvate kinase
  2. NM_001256262.1NP_001243191.1  pyruvate kinase PKLR isoform 1

    See identical proteins and their annotated locations for NP_001243191.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Isoform 1 is also known as type R.
    Source sequence(s)
    AAEX03005338
    UniProtKB/Swiss-Prot
    Q29536
    Related
    ENSCAFP00000024956.2, ENSCAFT00000026853.3
    Conserved Domains (1) summary
    cd00288
    Location:85573
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CanFam3.1 Primary Assembly

Genomic

  1. NC_006589.3 Reference CanFam3.1 Primary Assembly

    Range
    42263899..42272770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022420766.1XP_022276474.1  pyruvate kinase PKLR isoform X4

    Conserved Domains (1) summary
    cd00288
    Location:99587
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
  2. XM_022420763.1XP_022276471.1  pyruvate kinase PKLR isoform X1

    Conserved Domains (1) summary
    cl28161
    Location:85522
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
  3. XM_022420764.1XP_022276472.1  pyruvate kinase PKLR isoform X2

    Conserved Domains (1) summary
    cd00288
    Location:21509
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
  4. XM_014114980.2XP_013970455.1  pyruvate kinase PKLR isoform X2

    UniProtKB/TrEMBL
    H9KUV7
    Related
    ENSCAFP00000030738.2, ENSCAFT00000035475.2
    Conserved Domains (1) summary
    cd00288
    Location:21509
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
  5. XM_022420765.1XP_022276473.1  pyruvate kinase PKLR isoform X3

    Conserved Domains (1) summary
    cd00288
    Location:1467
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
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