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HMCN1 hemicentin 1 [ Canis lupus familiaris (dog) ]

Gene ID: 490318, updated on 25-Jul-2026
Official Symbol
HMCN1provided by VGNC
Official Full Name
hemicentin 1provided by VGNC
Primary source
VGNC:VGNC:41706
See related
Ensembl:ENSCAFG00845005182 RGD:12155158
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See HMCN1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
107
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (18532233..18990765)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (18318234..18776558)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (18679642..19137567)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (18440588..18897706)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (18548519..19007053)

Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L21-like Neighboring gene uncharacterized LOC119872667 Neighboring gene 1-acyl-sn-glycerol-3-phosphate acyltransferase beta-like Neighboring gene transcription factor BTF3-like Neighboring gene proteoglycan 4 Neighboring gene translocated promoter region, nuclear basket protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables axon guidance receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cell-cell adhesion mediator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dendrite self-avoidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in homophilic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in synapse organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
hemicentin-1
XP_038336883.1

Length

  • 5637
XP_547438.3

Length

  • 5637

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051811.1 Reference ROS_Cfam_1.0

    Range
    18532233..18990765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038671142.1 → XP_038527070.1  hemicentin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KP93, A0A8I3MXV4
    Related
    ENSCAFP00845007347.1, ENSCAFT00845009373.1
    Conserved Domains (12) summary
    smart00179
    Location:5434 → 5473
    EGF_CA; Calcium-binding EGF-like domain
    smart00209
    Location:4705 → 4757
    TSP1; Thrombospondin type 1 repeats
    smart00409
    Location:1462 → 1544
    IG; Immunoglobulin
    smart00410
    Location:898 → 979
    IG_like; Immunoglobulin like
    smart00682
    Location:4870 → 5094
    G2F; G2 nidogen domain and fibulin
    cd00054
    Location:5232 → 5265
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00198
    Location:44 → 200
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam07645
    Location:5274 → 5315
    EGF_CA; Calcium-binding EGF domain
    pfam07679
    Location:1173 → 1260
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:794 → 873
    Ig_3; Immunoglobulin domain
    cd00096
    Location:450 → 515
    Ig; Immunoglobulin domain
    cl11960
    Location:4443 → 4528
    Ig; Immunoglobulin domain

  2. XM_038671144.1 → XP_038527072.1  hemicentin-1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KP93
    Conserved Domains (12) summary
    smart00179
    Location:5317 → 5356
    EGF_CA; Calcium-binding EGF-like domain
    smart00209
    Location:4705 → 4757
    TSP1; Thrombospondin type 1 repeats
    smart00409
    Location:1088 → 1169
    IG; Immunoglobulin
    smart00410
    Location:1462 → 1544
    IG_like; Immunoglobulin like
    smart00682
    Location:4870 → 5094
    G2F; G2 nidogen domain and fibulin
    cd00054
    Location:5232 → 5265
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00198
    Location:44 → 200
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam07645
    Location:5274 → 5315
    EGF_CA; Calcium-binding EGF domain
    pfam07679
    Location:1173 → 1260
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:794 → 873
    Ig_3; Immunoglobulin domain
    cd00096
    Location:450 → 515
    Ig; Immunoglobulin domain
    cl11960
    Location:4443 → 4528
    Ig; Immunoglobulin domain

  3. XM_038671143.1 → XP_038527071.1  hemicentin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KP93
    Conserved Domains (12) summary
    smart00179
    Location:5340 → 5379
    EGF_CA; Calcium-binding EGF-like domain
    smart00209
    Location:4611 → 4663
    TSP1; Thrombospondin type 1 repeats
    smart00409
    Location:898 → 979
    IG; Immunoglobulin
    smart00410
    Location:1462 → 1544
    IG_like; Immunoglobulin like
    smart00682
    Location:4776 → 5000
    G2F; G2 nidogen domain and fibulin
    cd00054
    Location:5138 → 5171
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00198
    Location:44 → 200
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam07645
    Location:5180 → 5221
    EGF_CA; Calcium-binding EGF domain
    pfam07679
    Location:1173 → 1260
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:794 → 873
    Ig_3; Immunoglobulin domain
    cd00096
    Location:450 → 515
    Ig; Immunoglobulin domain
    cl11960
    Location:4349 → 4434
    Ig; Immunoglobulin domain

  4. XM_038671145.1 → XP_038527073.1  hemicentin-1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KRB0
    Conserved Domains (8) summary
    smart00209
    Location:4705 → 4757
    TSP1; Thrombospondin type 1 repeats
    smart00409
    Location:801 → 886
    IG; Immunoglobulin
    smart00410
    Location:898 → 979
    IG_like; Immunoglobulin like
    cd00198
    Location:44 → 200
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam07679
    Location:1173 → 1260
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:3152 → 3230
    Ig_3; Immunoglobulin domain
    cd00096
    Location:450 → 515
    Ig; Immunoglobulin domain
    cl11960
    Location:4443 → 4528
    Ig; Immunoglobulin domain

  5. XM_038671146.1 → XP_038527074.1  hemicentin-1 isoform X5

    UniProtKB/TrEMBL
    A0A8C0KP93
    Conserved Domains (11) summary
    smart00179
    Location:4453 → 4492
    EGF_CA; Calcium-binding EGF-like domain
    smart00209
    Location:3724 → 3776
    TSP1; Thrombospondin type 1 repeats
    smart00409
    Location:481 → 563
    IG; Immunoglobulin
    smart00410
    Location:107 → 188
    IG_like; Immunoglobulin like
    smart00682
    Location:3889 → 4113
    G2F; G2 nidogen domain and fibulin
    cd00054
    Location:4251 → 4284
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:4293 → 4334
    EGF_CA; Calcium-binding EGF domain
    pfam07679
    Location:192 → 279
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:2171 → 2249
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3462 → 3465
    Ig; Ig strand A [structural motif]
    cl11960
    Location:3462 → 3547
    Ig; Immunoglobulin domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049267.1 Alternate UMICH_Zoey_3.1

    Range
    18440588..18897706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038480955.1 → XP_038336883.1  

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

    Range
    18548519..19007053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038606475.1 → XP_038462403.1  

  2. XM_038606477.1 → XP_038462405.1  

  3. XM_038606476.1 → XP_038462404.1  

  4. XM_038606478.1 → XP_038462406.1  

  5. XM_038606479.1 → XP_038462407.1  

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

    Range
    18679642..19137567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038542311.1 → XP_038398239.1  hemicentin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KP93

  2. XM_038542313.1 → XP_038398241.1  hemicentin-1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KP93

  3. XM_038542312.1 → XP_038398240.1  hemicentin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KP93

  4. XM_038542314.1 → XP_038398242.1  hemicentin-1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KRB0

  5. XM_038542315.1 → XP_038398243.1  hemicentin-1 isoform X5

    UniProtKB/TrEMBL
    A0A8C0KP93

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    18318234..18776558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_547438.6 → XP_547438.3  hemicentin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KP93
    Conserved Domains (12) summary
    smart00179
    Location:5434 → 5473
    EGF_CA; Calcium-binding EGF-like domain
    smart00209
    Location:4705 → 4757
    TSP1; Thrombospondin type 1 repeats
    smart00409
    Location:898 → 979
    IG; Immunoglobulin
    smart00410
    Location:1462 → 1544
    IG_like; Immunoglobulin like
    smart00682
    Location:4870 → 5094
    G2F; G2 nidogen domain and fibulin
    cd00054
    Location:5232 → 5265
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00198
    Location:44 → 200
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam07645
    Location:5274 → 5315
    EGF_CA; Calcium-binding EGF domain
    pfam07679
    Location:1173 → 1260
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:794 → 873
    Ig_3; Immunoglobulin domain
    cd00096
    Location:450 → 515
    Ig; Immunoglobulin domain
    cl11960
    Location:4443 → 4528
    Ig; Immunoglobulin domain
Nucleotide Protein
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