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CRB1 crumbs cell polarity complex component 1 [ Canis lupus familiaris (dog) ]

Gene ID: 490260, updated on 25-Jul-2026
Official Symbol
CRB1provided by VGNC
Official Full Name
crumbs cell polarity complex component 1provided by VGNC
Primary source
VGNC:VGNC:39593
See related
Ensembl:ENSCAFG00845000998 RGD:12101988
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See CRB1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (4967450..5180345, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (4896806..5113389, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (5042374..5255595, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (4909374..5120084, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (5009956..5223118, complement)

Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102154048 Neighboring gene DENN domain containing 1B Neighboring gene 40S ribosomal protein S6-like Neighboring gene uncharacterized LOC111096600 Neighboring gene uncharacterized LOC106559013 Neighboring gene zinc finger and BTB domain containing 41

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex. Li Y, et al. Proc Natl Acad Sci U S A, 2014 Dec 9. PMID 25385611, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem has a highly specific assembly mechanism for the apical Crumbs complex
    Title: Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in establishment or maintenance of epithelial cell apical/basal polarity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heterophilic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
protein crumbs homolog 1
Names
crumbs 1, cell polarity complex component
crumbs homolog 1
XP_038336587.1

Length

  • 1336

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051811.1 Reference ROS_Cfam_1.0

    Range
    4967450..5180345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038670808.1 → XP_038526736.1  protein crumbs homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MG92, A0A8I3RPL4
    Related
    ENSCAFP00845001375.1, ENSCAFT00845001740.1
    Conserved Domains (4) summary
    smart00179
    Location:397 → 438
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:148 → 183
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:114 → 144
    EGF; EGF-like domain
    pfam02210
    Location:514 → 651
    Laminin_G_2; Laminin G domain

  2. XM_038670809.1 → XP_038526737.1  protein crumbs homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KHK6
    Conserved Domains (4) summary
    smart00179
    Location:328 → 369
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:79 → 114
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:45 → 75
    EGF; EGF-like domain
    pfam02210
    Location:445 → 582
    Laminin_G_2; Laminin G domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049267.1 Alternate UMICH_Zoey_3.1

    Range
    4909374..5120084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038480659.1 → XP_038336587.1  

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

    Range
    5009956..5223118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038606117.1 → XP_038462045.1  

  2. XM_038606118.1 → XP_038462046.1  

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

    Range
    5042374..5255595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038541982.1 → XP_038397910.1  protein crumbs homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MG92

  2. XM_038541983.1 → XP_038397911.1  protein crumbs homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KHK6
    Conserved Domains (4) summary
    smart00179
    Location:328 → 369
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:79 → 114
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:45 → 75
    EGF; EGF-like domain
    pfam02210
    Location:445 → 582
    Laminin_G_2; Laminin G domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    4896806..5113389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005622293.4 → XP_005622350.1  protein crumbs homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MG92
    Conserved Domains (4) summary
    smart00179
    Location:397 → 438
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:148 → 183
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:114 → 144
    EGF; EGF-like domain
    pfam02210
    Location:514 → 651
    Laminin_G_2; Laminin G domain

  2. XM_038561594.1 → XP_038417522.1  protein crumbs homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KHK6
    Conserved Domains (4) summary
    smart00179
    Location:328 → 369
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:79 → 114
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:45 → 75
    EGF; EGF-like domain
    pfam02210
    Location:445 → 582
    Laminin_G_2; Laminin G domain
Nucleotide Protein
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