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DENND2D DENN domain containing 2D [ Canis lupus familiaris (dog) ]

Gene ID: 490105, updated on 25-Jul-2026
Official Symbol
DENND2Dprovided by VGNC
Official Full Name
DENN domain containing 2Dprovided by VGNC
Primary source
VGNC:VGNC:39888
See related
Ensembl:ENSCAFG00845001602 RGD:12121238
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See DENND2D in Genome Data Viewer
Location:
chromosome: 6
Exon count:
15
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (41149953..41168235)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (43596024..43614302)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (41276466..41294747)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (40871245..40889500)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (40841183..40859457)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene protein pitchfork-like Neighboring gene uncharacterized LOC119872346 Neighboring gene chitinase acidic Neighboring gene choline/ethanolamine phosphotransferase 1 Neighboring gene uncharacterized LOC111096341 Neighboring gene DNA damage regulated autophagy modulator 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
DENN domain-containing protein 2D

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    41149953..41168235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038669802.1 → XP_038525730.1  DENN domain-containing protein 2D isoform X2

    UniProtKB/TrEMBL
    A0A8C0KB93, A0A8I3MKV7
    Related
    ENSCAFP00845002191.1, ENSCAFT00845002765.1
    Conserved Domains (3) summary
    smart00801
    Location:389 → 454
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:45 → 137
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:144 → 316
    DENN; DENN (AEX-3) domain

  2. XM_038669804.1 → XP_038525732.1  DENN domain-containing protein 2D isoform X4

    UniProtKB/TrEMBL
    A0A8C0KB93
    Conserved Domains (3) summary
    smart00801
    Location:369 → 434
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:47 → 139
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:146 → 330
    DENN; DENN (AEX-3) domain

  3. XM_038669801.1 → XP_038525729.1  DENN domain-containing protein 2D isoform X1

    UniProtKB/TrEMBL
    A0A8C0KB93, A0A8I3MKY2
    Related
    ENSCAFP00845002239.1, ENSCAFT00845002816.1
    Conserved Domains (3) summary
    smart00801
    Location:399 → 464
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:55 → 147
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:154 → 326
    DENN; DENN (AEX-3) domain

  4. XM_038669803.1 → XP_038525731.1  DENN domain-containing protein 2D isoform X3

    UniProtKB/TrEMBL
    A0A8C0K940, A0A8C0KB93
    Conserved Domains (3) summary
    smart00801
    Location:377 → 442
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:55 → 147
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:154 → 338
    DENN; DENN (AEX-3) domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    40871245..40889500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038479730.1 → XP_038335658.1  

    Conserved Domains (3) summary
    smart00801
    Location:389 → 454
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:45 → 137
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:144 → 316
    DENN; DENN (AEX-3) domain

  2. XM_038479732.1 → XP_038335660.1  

    Conserved Domains (3) summary
    smart00801
    Location:369 → 434
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:47 → 139
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:146 → 330
    DENN; DENN (AEX-3) domain

  3. XM_038479729.1 → XP_038335657.1  

    Conserved Domains (3) summary
    smart00801
    Location:399 → 464
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:55 → 147
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:154 → 326
    DENN; DENN (AEX-3) domain

  4. XM_038479731.1 → XP_038335659.1  

    Conserved Domains (3) summary
    smart00801
    Location:377 → 442
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:55 → 147
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:154 → 338
    DENN; DENN (AEX-3) domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    40841183..40859457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038605128.1 → XP_038461056.1  

    Conserved Domains (3) summary
    smart00801
    Location:389 → 454
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:45 → 137
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:144 → 316
    DENN; DENN (AEX-3) domain

  2. XM_038605130.1 → XP_038461058.1  

    Conserved Domains (3) summary
    smart00801
    Location:369 → 434
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:47 → 139
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:146 → 330
    DENN; DENN (AEX-3) domain

  3. XM_038605127.1 → XP_038461055.1  

    Conserved Domains (3) summary
    smart00801
    Location:399 → 464
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:55 → 147
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:154 → 326
    DENN; DENN (AEX-3) domain

  4. XM_038605129.1 → XP_038461057.1  

    Conserved Domains (3) summary
    smart00801
    Location:377 → 442
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:55 → 147
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:154 → 338
    DENN; DENN (AEX-3) domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    41276466..41294747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038541000.1 → XP_038396928.1  DENN domain-containing protein 2D isoform X2

    UniProtKB/TrEMBL
    A0A8C0KB93, A0A8I3MKV7
    Conserved Domains (3) summary
    smart00801
    Location:389 → 454
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:45 → 137
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:144 → 316
    DENN; DENN (AEX-3) domain

  2. XM_038541002.1 → XP_038396930.1  DENN domain-containing protein 2D isoform X4

    UniProtKB/TrEMBL
    A0A8C0KB93
    Conserved Domains (3) summary
    smart00801
    Location:369 → 434
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:47 → 139
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:146 → 330
    DENN; DENN (AEX-3) domain

  3. XM_038540999.1 → XP_038396927.1  DENN domain-containing protein 2D isoform X1

    UniProtKB/TrEMBL
    A0A8C0KB93, A0A8I3MKY2
    Conserved Domains (3) summary
    smart00801
    Location:399 → 464
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:55 → 147
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:154 → 326
    DENN; DENN (AEX-3) domain

  4. XM_038541001.1 → XP_038396929.1  DENN domain-containing protein 2D isoform X3

    UniProtKB/TrEMBL
    A0A8C0K940, A0A8C0KB93
    Conserved Domains (3) summary
    smart00801
    Location:377 → 442
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:55 → 147
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:154 → 338
    DENN; DENN (AEX-3) domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    43596024..43614302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038551627.1 → XP_038407555.1  DENN domain-containing protein 2D isoform X2

    UniProtKB/TrEMBL
    A0A8C0KB93, A0A8I3MKV7
    Conserved Domains (3) summary
    smart00801
    Location:389 → 454
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:45 → 137
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:144 → 316
    DENN; DENN (AEX-3) domain

  2. XM_038551631.1 → XP_038407559.1  DENN domain-containing protein 2D isoform X4

    UniProtKB/TrEMBL
    A0A8C0KB93
    Conserved Domains (3) summary
    smart00801
    Location:369 → 434
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:47 → 139
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:146 → 330
    DENN; DENN (AEX-3) domain

  3. XM_038551621.1 → XP_038407549.1  DENN domain-containing protein 2D isoform X1

    UniProtKB/TrEMBL
    A0A8C0KB93, A0A8I3MKY2
    Conserved Domains (3) summary
    smart00801
    Location:399 → 464
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:55 → 147
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:154 → 326
    DENN; DENN (AEX-3) domain

  4. XM_547226.7 → XP_547226.3  DENN domain-containing protein 2D isoform X3

    UniProtKB/TrEMBL
    A0A8C0K940, A0A8C0KB93
    Conserved Domains (3) summary
    smart00801
    Location:377 → 442
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:55 → 147
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:154 → 338
    DENN; DENN (AEX-3) domain
Nucleotide Protein
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