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WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 [ Canis lupus familiaris (dog) ]

Gene ID: 490094, updated on 27-Jun-2026
Official Symbol
WFIKKN1provided by VGNC
Official Full Name
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1provided by VGNC
Primary source
VGNC:VGNC:48406
See related
Ensembl:ENSCAFG00845027942 RGD:12117232
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See WFIKKN1 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
2
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (40276276..40279832, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (41197722..41201278, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (40404167..40407723, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (39964800..39968355, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (39924986..39928542, complement)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene methyltransferase like 26 Neighboring gene RAB40C, member RAS oncogene family Neighboring gene phosphatidylinositol glycan anchor biosynthesis class Q

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables receptor antagonist activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transforming growth factor beta binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    40276276..40279832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038669724.1 → XP_038525652.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1

    UniProtKB/TrEMBL
    A0A8C0QXP7, A0A8I3QAQ1
    Related
    ENSCAFP00845038702.1, ENSCAFT00845049318.1
    Conserved Domains (7) summary
    cd00104
    Location:196 → 233
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00014
    Location:433 → 484
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:104 → 153
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    cd00096
    Location:270 → 273
    Ig; Ig strand A' [structural motif]
    cl00101
    Location:392 → 426
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cl02512
    Location:502 → 613
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    cl11960
    Location:264 → 356
    Ig; Immunoglobulin domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    39964800..39968355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038479644.1 → XP_038335572.1  

    Conserved Domains (7) summary
    cd00104
    Location:196 → 233
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00014
    Location:433 → 484
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:104 → 153
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    cd00096
    Location:270 → 273
    Ig; Ig strand A' [structural motif]
    cl00101
    Location:392 → 426
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cl02512
    Location:502 → 613
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    cl11960
    Location:264 → 356
    Ig; Immunoglobulin domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    39924986..39928542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038605048.1 → XP_038460976.1  

    Conserved Domains (7) summary
    cd00104
    Location:196 → 233
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00014
    Location:433 → 484
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:104 → 153
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    cd00096
    Location:270 → 273
    Ig; Ig strand A' [structural motif]
    cl00101
    Location:392 → 426
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cl02512
    Location:502 → 613
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    cl11960
    Location:264 → 356
    Ig; Immunoglobulin domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    40404167..40407723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038540923.1 → XP_038396851.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1

    UniProtKB/TrEMBL
    A0A8C0QXP7, A0A8I3QAQ1
    Conserved Domains (7) summary
    cd00104
    Location:196 → 233
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00014
    Location:433 → 484
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:104 → 153
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    cd00096
    Location:270 → 273
    Ig; Ig strand A' [structural motif]
    cl00101
    Location:392 → 426
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cl02512
    Location:502 → 613
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    cl11960
    Location:264 → 356
    Ig; Immunoglobulin domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    41197722..41201278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_547215.7 → XP_547215.5  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1

    UniProtKB/TrEMBL
    A0A8C0QXP7, A0A8I3QAQ1
    Conserved Domains (7) summary
    cd00104
    Location:196 → 233
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00014
    Location:433 → 484
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:104 → 153
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
    cd00096
    Location:270 → 273
    Ig; Ig strand A' [structural motif]
    cl00101
    Location:392 → 426
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cl02512
    Location:502 → 613
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    cl11960
    Location:264 → 356
    Ig; Immunoglobulin domain
Nucleotide Protein
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