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PRSS22 serine protease 22 [ Canis lupus familiaris (dog) ]

Gene ID: 490056, updated on 25-Jul-2026
Official Symbol
PRSS22provided by VGNC
Official Full Name
serine protease 22provided by VGNC
Primary source
VGNC:VGNC:45064
See related
Ensembl:ENSCAFG00845003694 RGD:12213966
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
Try the new Gene page
Try the new Transcripts and proteins table
See PRSS22 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
6
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (38681253..38685140, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (39610463..39614342, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (38815136..38819018, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (38366440..38370320, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (38339117..38342985, complement)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119872341 Neighboring gene zymogen granule protein 16B Neighboring gene uncharacterized LOC111096325 Neighboring gene uncharacterized LOC119872214 Neighboring gene uncharacterized LOC119872215

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
PubMed 
Preferred Names
brain-specific serine protease 4
Names
protease, serine 22

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    38681253..38685140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038669489.1XP_038525417.1  brain-specific serine protease 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LR83, A0A8I3N6E6
    Related
    ENSCAFP00845005271.1, ENSCAFT00845006624.1
    Conserved Domains (1) summary
    cd00190
    Location:50288
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_038669490.1XP_038525418.1  brain-specific serine protease 4 isoform X2

    Conserved Domains (1) summary
    cd00190
    Location:50190
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    38366440..38370320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038479423.1XP_038335351.1  

    Conserved Domains (1) summary
    cd00190
    Location:50288
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_038479424.1XP_038335352.1  

    Conserved Domains (1) summary
    cd00190
    Location:50190
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    38339117..38342985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038604803.1XP_038460731.1  

    Conserved Domains (1) summary
    cd00190
    Location:50288
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_038604804.1XP_038460732.1  

    Conserved Domains (1) summary
    cd00190
    Location:50190
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    38815136..38819018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038540682.1XP_038396610.1  brain-specific serine protease 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LR83, A0A8I3N6E6
    Conserved Domains (1) summary
    cd00190
    Location:50288
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_038540683.1XP_038396611.1  brain-specific serine protease 4 isoform X2

    Conserved Domains (1) summary
    cd00190
    Location:50190
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    39610463..39614342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022420233.2XP_022275941.2  brain-specific serine protease 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LR83, A0A8I3N6E6
    Conserved Domains (1) summary
    cd00190
    Location:50288
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_038549498.1XP_038405426.1  brain-specific serine protease 4 isoform X2

    Conserved Domains (1) summary
    cd00190
    Location:50190
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...