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ACR acrosin [ Homo sapiens (human) ]

Gene ID: 49, updated on 5-Aug-2018

Summary

Official Symbol
ACRprovided by HGNC
Official Full Name
acrosinprovided by HGNC
Primary source
HGNC:HGNC:126
See related
Ensembl:ENSG00000100312 MIM:102480; Vega:OTTHUMG00000150155
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 44.8) See more
Orthologs

Genomic context

See ACR in Genome Data Viewer
Location:
22q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (50738224..50745299)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (51176652..51183727)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene SH3 and multiple ankyrin repeat domains 3 Neighboring gene RNA, U6 small nuclear 409, pseudogene Neighboring gene uncharacterized LOC105373100 Neighboring gene small nuclear ribonucleoprotein polypeptide A' pseudogene Neighboring gene ribosomal protein L23a pseudogene 82 Neighboring gene RAB, member of RAS oncogene family like 2B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Acrosome Reaction, organism-specific biosystem (from REACTOME)
    Acrosome Reaction, organism-specific biosystemThe acrosome reaction is stimulated by zona pellucida binding and subsequent downstream events, including Ca2+ influx. Proacrosin cleavage is the hallmark event of the acrosome reaction.
  • Fertilization, organism-specific biosystem (from REACTOME)
    Fertilization, organism-specific biosystemMammalian fertilization comprises sperm migration through the female reproductive tract, biochemical and morphological changes to sperm, and sperm-egg interaction in the oviduct. Although the broad c...
  • Reproduction, organism-specific biosystem (from REACTOME)
    Reproduction, organism-specific biosystemHuman reproduction mixes the genomes of two individuals creating a new organism. The offspring individuals produced by sexual reproduction differ from their parents and from their siblings. Reproduct...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
amidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
copper ion binding NAS
Non-traceable Author Statement
more info
PubMed 
drug binding ISS
Inferred from Sequence or Structural Similarity
more info
 
fucose binding ISS
Inferred from Sequence or Structural Similarity
more info
 
mannose binding IDA
Inferred from Direct Assay
more info
PubMed 
protease binding TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acrosome matrix dispersal NAS
Non-traceable Author Statement
more info
PubMed 
acrosome reaction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acrosome reaction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acrosome reaction TAS
Traceable Author Statement
more info
 
activation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
binding of sperm to zona pellucida IEA
Inferred from Electronic Annotation
more info
 
penetration of zona pellucida IEA
Inferred from Electronic Annotation
more info
 
response to steroid hormone IEA
Inferred from Electronic Annotation
more info
 
single fertilization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi-associated vesicle IEA
Inferred from Electronic Annotation
more info
 
acrosomal matrix TAS
Traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
acrosin
Names
acrosin light and heavy chain prepropeptide
preproacrosin
proacrosin
NP_001088.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097.2NP_001088.2  acrosin precursor

    See identical proteins and their annotated locations for NP_001088.2

    Status: REVIEWED

    Source sequence(s)
    CR456366, DB054152, Y00970
    Consensus CDS
    CCDS14101.1
    UniProtKB/Swiss-Prot
    P10323
    Related
    ENSP00000216139.5, OTTHUMP00000196479, ENST00000216139.9, OTTHUMT00000316605
    Conserved Domains (2) summary
    smart00020
    Location:42285
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:43288
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    50738224..50745299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_015148969.1 Reference GRCh38.p12 PATCHES

    Range
    74341..81410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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