U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ERN2 endoplasmic reticulum to nucleus signaling 2 [ Canis lupus familiaris (dog) ]

Gene ID: 489970, updated on 27-Jun-2026
Official Symbol
ERN2provided by VGNC
Official Full Name
endoplasmic reticulum to nucleus signaling 2provided by VGNC
Primary source
VGNC:VGNC:40465
See related
Ensembl:ENSCAFG00845001451 RGD:12198897
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See ERN2 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (22293767..22309179)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (23717029..23732220)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (22395153..22410360)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (22097649..22112813)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (21999693..22014916)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene collagen alpha-1(I) chain-like Neighboring gene calcineurin like EF-hand protein 2 Neighboring gene polo like kinase 1 Neighboring gene uncharacterized LOC111096276 Neighboring gene dynactin subunit 5 Neighboring gene partner and localizer of BRCA2 Neighboring gene uncharacterized LOC111096275

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of IRE1-TRAF2-ASK1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
serine/threonine-protein kinase/endoribonuclease IRE2
Names
endoplasmic reticulum to nucleus signalling 2
XP_022275654.1
XP_038334711.1
XP_038395958.1
XP_038460035.1
XP_038460036.1
XP_038524756.1
XP_038524757.1
XP_547090.3

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    22293767..22309179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038668828.1 → XP_038524756.1  serine/threonine-protein kinase/endoribonuclease IRE2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MG68
    Related
    ENSCAFP00845002105.1, ENSCAFT00845002652.1
    Conserved Domains (3) summary
    cd09769
    Location:34 → 292
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:784 → 909
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:515 → 781
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

  2. XM_038668829.1 → XP_038524757.1  serine/threonine-protein kinase/endoribonuclease IRE2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3MG68
    Conserved Domains (3) summary
    cd09769
    Location:11 → 269
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:761 → 886
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:492 → 758
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    22097649..22112813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038478783.1 → XP_038334711.1  

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    21999693..22014916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038604107.1 → XP_038460035.1  

    Conserved Domains (3) summary
    cd09769
    Location:34 → 292
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:784 → 909
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:515 → 781
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

  2. XM_038604108.1 → XP_038460036.1  

    Conserved Domains (3) summary
    cd09769
    Location:11 → 269
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:761 → 886
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:492 → 758
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    22395153..22410360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038540030.1 → XP_038395958.1  serine/threonine-protein kinase/endoribonuclease IRE2 isoform X4

    UniProtKB/TrEMBL
    A0A8I3MG68

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    23717029..23732220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_547090.7 → XP_547090.3  serine/threonine-protein kinase/endoribonuclease IRE2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MG68
    Conserved Domains (3) summary
    cd09769
    Location:34 → 292
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:784 → 909
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:515 → 781
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

  2. XM_022419946.2 → XP_022275654.1  serine/threonine-protein kinase/endoribonuclease IRE2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3MG68
    Conserved Domains (3) summary
    cd09769
    Location:11 → 269
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:761 → 886
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:492 → 758
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials