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TFR2 transferrin receptor 2 [ Canis lupus familiaris (dog) ]

Gene ID: 489834, updated on 27-Jun-2026
Official Symbol
TFR2provided by VGNC
Official Full Name
transferrin receptor 2provided by VGNC
Primary source
VGNC:VGNC:47304
See related
Ensembl:ENSCAFG00845001347 RGD:12142751
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See TFR2 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
19
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (8993681..9010842)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (10763917..10781061)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (9006114..9023274)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (8846198..8863361)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (8823694..8841037)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene G protein subunit beta 2 Neighboring gene actin like 6B Neighboring gene uncharacterized LOC111096206 Neighboring gene motile sperm domain containing 3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables transferrin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytic iron import into cell IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transferrin transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
transferrin receptor protein 2

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    8993681..9010842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038668034.1 → XP_038523962.1  transferrin receptor protein 2

    UniProtKB/TrEMBL
    A0A8C0KP87, A0A8I3MDN1
    Related
    ENSCAFP00845001837.1, ENSCAFT00845002317.1
    Conserved Domains (4) summary
    cd02128
    Location:210 → 401
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:409 → 642
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:669 → 796
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:143 → 196
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

  2. XM_038668033.1 → XP_038523961.1  transferrin receptor protein 2

    UniProtKB/TrEMBL
    A0A8C0KP87, A0A8I3MDN1
    Conserved Domains (4) summary
    cd02128
    Location:210 → 401
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:409 → 642
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:669 → 796
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:143 → 196
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    8846198..8863361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038477988.1 → XP_038333916.1  

    Conserved Domains (4) summary
    cd02128
    Location:210 → 401
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:409 → 642
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:669 → 796
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:143 → 196
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

  2. XM_038477987.1 → XP_038333915.1  

    Conserved Domains (4) summary
    cd02128
    Location:210 → 401
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:409 → 642
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:669 → 796
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:143 → 196
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    8823694..8841037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038603329.1 → XP_038459257.1  

    Conserved Domains (4) summary
    cd02128
    Location:210 → 401
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:409 → 642
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:669 → 796
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:143 → 196
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

  2. XM_038603328.1 → XP_038459256.1  

    Conserved Domains (4) summary
    cd02128
    Location:210 → 401
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:409 → 642
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:669 → 796
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:143 → 196
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    9006114..9023274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038539249.1 → XP_038395177.1  transferrin receptor protein 2

    UniProtKB/TrEMBL
    A0A8C0KP87, A0A8I3MDN1
    Conserved Domains (4) summary
    cd02128
    Location:210 → 401
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:409 → 642
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:669 → 796
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:143 → 196
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

  2. XM_038539248.1 → XP_038395176.1  transferrin receptor protein 2

    UniProtKB/TrEMBL
    A0A8C0KP87, A0A8I3MDN1
    Conserved Domains (4) summary
    cd02128
    Location:210 → 401
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:409 → 642
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:669 → 796
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:143 → 196
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    10763917..10781061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_546952.7 → XP_546952.2  transferrin receptor protein 2

    See identical proteins and their annotated locations for XP_546952.2

    UniProtKB/TrEMBL
    A0A8C0KP87, A0A8I3MDN1
    Conserved Domains (4) summary
    cd02128
    Location:210 → 401
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:409 → 642
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:669 → 796
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:143 → 196
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

  2. XM_022419636.2 → XP_022275344.1  transferrin receptor protein 2

    UniProtKB/TrEMBL
    A0A8C0KP87, A0A8I3MDN1
    Conserved Domains (4) summary
    cd02128
    Location:210 → 401
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:409 → 642
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:669 → 796
    TFR_dimer; Transferrin receptor-like dimerization domain
    cl14876
    Location:143 → 196
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
Nucleotide Protein
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