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EPHB4 EPH receptor B4 [ Canis lupus familiaris (dog) ]

Gene ID: 489830, updated on 27-Jun-2026
Official Symbol
EPHB4provided by VGNC
Official Full Name
EPH receptor B4provided by VGNC
Primary source
VGNC:VGNC:40413
See related
Ensembl:ENSCAFG00845000816 RGD:12402554
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See EPHB4 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (8861650..8879327)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (10631634..10649370)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (8874020..8891770)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (8714171..8731877)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (8692052..8709742)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 member 9 Neighboring gene uncharacterized LOC119872322 Neighboring gene zonadhesin Neighboring gene erythropoietin

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane-ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in central nervous system projection neuron axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
ephrin type-B receptor 4
XP_038333905.1
XP_038395164.1
XP_038459244.1
XP_038523949.1
XP_546948.3

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    8861650..8879327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038668021.1 → XP_038523949.1  ephrin type-B receptor 4

    UniProtKB/TrEMBL
    A0A8C0KJ14, A0A8I3MBN5
    Related
    ENSCAFP00845001051.1, ENSCAFT00845001362.1
    Conserved Domains (5) summary
    cd05065
    Location:610 → 878
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09554
    Location:907 → 973
    SAM_EPH-B4; SAM domain of EPH-B4 subfamily of tyrosine kinase receptors
    cd10474
    Location:17 → 196
    EphR_LBD_B4; Ligand Binding Domain of Ephrin type-B Receptor 4
    cd00063
    Location:434 → 526
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam14575
    Location:562 → 612
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    8714171..8731877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038477977.1 → XP_038333905.1  

    Conserved Domains (5) summary
    cd05065
    Location:610 → 878
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09554
    Location:907 → 973
    SAM_EPH-B4; SAM domain of EPH-B4 subfamily of tyrosine kinase receptors
    cd10474
    Location:17 → 196
    EphR_LBD_B4; Ligand Binding Domain of Ephrin type-B Receptor 4
    cd00063
    Location:434 → 526
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam14575
    Location:562 → 612
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    8692052..8709742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038603316.1 → XP_038459244.1  

    Conserved Domains (5) summary
    cd05065
    Location:610 → 878
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09554
    Location:907 → 973
    SAM_EPH-B4; SAM domain of EPH-B4 subfamily of tyrosine kinase receptors
    cd10474
    Location:17 → 196
    EphR_LBD_B4; Ligand Binding Domain of Ephrin type-B Receptor 4
    cd00063
    Location:434 → 526
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam14575
    Location:562 → 612
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    8874020..8891770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038539236.1 → XP_038395164.1  ephrin type-B receptor 4

    UniProtKB/TrEMBL
    A0A8C0KJ14, A0A8I3MBN5
    Conserved Domains (5) summary
    cd05065
    Location:610 → 878
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09554
    Location:907 → 973
    SAM_EPH-B4; SAM domain of EPH-B4 subfamily of tyrosine kinase receptors
    cd10474
    Location:17 → 196
    EphR_LBD_B4; Ligand Binding Domain of Ephrin type-B Receptor 4
    cd00063
    Location:434 → 526
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam14575
    Location:562 → 612
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    10631634..10649370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_546948.7 → XP_546948.3  ephrin type-B receptor 4

    UniProtKB/TrEMBL
    A0A8C0KJ14, A0A8I3MBN5
    Conserved Domains (5) summary
    cd05065
    Location:610 → 878
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09554
    Location:907 → 973
    SAM_EPH-B4; SAM domain of EPH-B4 subfamily of tyrosine kinase receptors
    cd10474
    Location:17 → 196
    EphR_LBD_B4; Ligand Binding Domain of Ephrin type-B Receptor 4
    cd00063
    Location:434 → 526
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam14575
    Location:562 → 612
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
Nucleotide Protein
Heading Accession and Version

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