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NRDC nardilysin convertase [ Homo sapiens (human) ]

Gene ID: 4898, updated on 1-Aug-2020

Summary

Official Symbol
NRDCprovided by HGNC
Official Full Name
nardilysin convertaseprovided by HGNC
Primary source
HGNC:HGNC:7995
See related
Ensembl:ENSG00000078618 MIM:602651
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRD1; hNRD1; hNRD2
Summary
This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Expression
Ubiquitous expression in testis (RPKM 55.2), skin (RPKM 27.3) and 25 other tissues See more
Orthologs

Genomic context

See NRDC in Genome Data Viewer
Location:
1p32.3
Exon count:
34
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (51789192..51878937, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (52254864..52344609, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein like 9 Neighboring gene solute carrier family 25 member 6 pseudogene 3 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 51 Neighboring gene uncharacterized LOC105378721 Neighboring gene microRNA 761 Neighboring gene Sharpr-MPRA regulatory region 5937 Neighboring gene tRNA splicing endonuclease subunit 15 pseudogene 2 Neighboring gene RAB3B, member RAS oncogene family Neighboring gene RNA, 5S ribosomal pseudogene 48 Neighboring gene ribosomal protein S26 pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, nardilysin (N-arginine dibasic convertase) (NRD1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with NRD1 is decreased by RRE PubMed
Vif vif HIV-1 Vif interacts with NRDC; interaction predicted to be relevant to proteolysis PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
epidermal growth factor binding TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell surface TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nardilysin
Names
NRD convertase
nardilysin (N-arginine dibasic convertase)
NP_001095132.1
NP_001229290.1
NP_002516.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029171.2 RefSeqGene

    Range
    5001..94746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001101662.2NP_001095132.1  nardilysin isoform b precursor

    See identical proteins and their annotated locations for NP_001095132.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AY360265, BC008775, DA245717, X93209
    Consensus CDS
    CCDS41335.1
    UniProtKB/Swiss-Prot
    O43847
    UniProtKB/TrEMBL
    Q6UUU9
    Related
    ENSP00000262679.8, ENST00000352171.11
    Conserved Domains (1) summary
    cl25708
    Location:1031089
    Peptidase_M16; Insulinase (Peptidase family M16)
  2. NM_001242361.1NP_001229290.1  nardilysin isoform c

    See identical proteins and their annotated locations for NP_001229290.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AY360265, BC008775, CA422553, DB084774
    Consensus CDS
    CCDS55599.1
    UniProtKB/Swiss-Prot
    O43847
    UniProtKB/TrEMBL
    G3V1R5, Q6UUU9
    Related
    ENSP00000444416.1, ENST00000539524.5
    Conserved Domains (1) summary
    cl25708
    Location:1471025
    Peptidase_M16; Insulinase (Peptidase family M16)
  3. NM_002525.2NP_002516.2  nardilysin isoform a

    See identical proteins and their annotated locations for NP_002516.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AY360265, BC008775, CA422553, DA245717, DA756064, X93207
    Consensus CDS
    CCDS559.1
    UniProtKB/Swiss-Prot
    O43847
    UniProtKB/TrEMBL
    B1AKJ5, Q6UUU9
    Related
    ENSP00000346890.7, ENST00000354831.11
    Conserved Domains (4) summary
    COG1025
    Location:2791157
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
    pfam00675
    Location:279405
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:430616
    Peptidase_M16_C; Peptidase M16 inactive domain
    pfam16187
    Location:621902
    Peptidase_M16_M; Middle or third domain of peptidase_M16

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    51789192..51878937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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