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PLCG2 phospholipase C gamma 2 [ Canis lupus familiaris (dog) ]

Gene ID: 489692, updated on 18-Sep-2020

Summary

Official Symbol
PLCG2provided by VGNC
Official Full Name
phospholipase C gamma 2provided by VGNC
Primary source
VGNC:VGNC:44652
See related
Ensembl:ENSCAFG00000019989
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs

Genomic context

See PLCG2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
38
Annotation release Status Assembly Chr Location
105 current CanFam3.1 (GCF_000002285.3) 5 NC_006587.3 (70054683..70233459, complement)

Chromosome 5 - NC_006587.3Genomic Context describing neighboring genes Neighboring gene hydroxysteroid 17-beta dehydrogenase 2 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 Neighboring gene uncharacterized LOC102154738 Neighboring gene c-Maf inducing protein Neighboring gene uncharacterized LOC111096019

Genomic regions, transcripts, and products

Genomic Sequence:
NC_006587.3 Chromosome 5 Reference CanFam3.1 Primary Assembly

Pathways from PubChem

General gene information

Markers

Homology

General protein information

Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
XP_005620714.1
XP_022274836.1
XP_022274838.1
XP_022274839.1
XP_022274840.1
XP_022274841.1
XP_546812.3

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CanFam3.1 Primary Assembly

Genomic

  1. NC_006587.3 Reference CanFam3.1 Primary Assembly

    Range
    70054683..70233459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022419131.1XP_022274839.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

    Conserved Domains (10) summary
    cd00275
    Location:10611187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:311458
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:641744
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527627
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:840910
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:22140
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:9261031
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:475510
    PH-like; Pleckstrin homology-like domain
  2. XM_005620657.3XP_005620714.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

    See identical proteins and their annotated locations for XP_005620714.1

    UniProtKB/TrEMBL
    E2RQM0
    Conserved Domains (10) summary
    cd00275
    Location:10611187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:311458
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:641744
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527627
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:840910
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:22140
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:9261031
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:475510
    PH-like; Pleckstrin homology-like domain
  3. XM_022419133.1XP_022274841.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

    Conserved Domains (10) summary
    cd00275
    Location:10611187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:311458
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:641744
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527627
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:840910
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:22140
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:9261031
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:475510
    PH-like; Pleckstrin homology-like domain
  4. XM_022419128.1XP_022274836.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

    Conserved Domains (10) summary
    cd00275
    Location:10611187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:311458
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:641744
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527627
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:840910
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:22140
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:9261031
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:475510
    PH-like; Pleckstrin homology-like domain
  5. XM_022419130.1XP_022274838.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

    Conserved Domains (10) summary
    cd00275
    Location:10611187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:311458
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:641744
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527627
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:840910
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:22140
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:9261031
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:475510
    PH-like; Pleckstrin homology-like domain
  6. XM_022419132.1XP_022274840.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

    Conserved Domains (10) summary
    cd00275
    Location:10611187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:311458
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:641744
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527627
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:840910
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:22140
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:9261031
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:475510
    PH-like; Pleckstrin homology-like domain
  7. XM_546812.6XP_546812.3  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

    See identical proteins and their annotated locations for XP_546812.3

    UniProtKB/TrEMBL
    E2RQM0
    Related
    ENSCAFP00000029622.4, ENSCAFT00000031815.4
    Conserved Domains (10) summary
    cd00275
    Location:10611187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:311458
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:641744
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527627
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:840910
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:22140
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:9261031
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:475510
    PH-like; Pleckstrin homology-like domain
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