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SPG7 SPG7 matrix AAA peptidase subunit, paraplegin [ Canis lupus familiaris (dog) ]

Gene ID: 489657, updated on 25-Jul-2026
Official Symbol
SPG7provided by VGNC
Official Full Name
SPG7 matrix AAA peptidase subunit, parapleginprovided by VGNC
Primary source
VGNC:VGNC:46736
See related
Ensembl:ENSCAFG00845002439 RGD:12192779
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See SPG7 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (64212077..64250632, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (63996864..64035406, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (64476292..64514838, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (64231998..64270537, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (64069471..64108027, complement)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102155777 Neighboring gene small nucleolar RNA MBII-202 Neighboring gene copine 7 Neighboring gene ribosomal protein L13 Neighboring gene ankyrin repeat domain containing 11 Neighboring gene solute carrier family 22 member 31

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP-dependent peptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of m-AAA complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
paraplegin
Names
SPG7, paraplegin matrix AAA peptidase subunit

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    64212077..64250632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038666753.1 → XP_038522681.1  paraplegin

    UniProtKB/TrEMBL
    A0A8C0JXB0, A0A8I3MG69
    Related
    ENSCAFP00845003494.1, ENSCAFT00845004372.1
    Conserved Domains (2) summary
    TIGR01241
    Location:265 → 748
    FtsH_fam; ATP-dependent metalloprotease FtsH
    pfam06480
    Location:145 → 242
    FtsH_ext; FtsH Extracellular

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    64231998..64270537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038476850.1 → XP_038332778.1  

    Conserved Domains (2) summary
    TIGR01241
    Location:265 → 748
    FtsH_fam; ATP-dependent metalloprotease FtsH
    pfam06480
    Location:145 → 242
    FtsH_ext; FtsH Extracellular

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    64069471..64108027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038602147.1 → XP_038458075.1  

    Conserved Domains (2) summary
    TIGR01241
    Location:265 → 748
    FtsH_fam; ATP-dependent metalloprotease FtsH
    pfam06480
    Location:145 → 242
    FtsH_ext; FtsH Extracellular

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    64476292..64514838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038538013.1 → XP_038393941.1  paraplegin

    UniProtKB/TrEMBL
    A0A8C0JXB0, A0A8I3MG69
    Conserved Domains (2) summary
    TIGR01241
    Location:265 → 748
    FtsH_fam; ATP-dependent metalloprotease FtsH
    pfam06480
    Location:145 → 242
    FtsH_ext; FtsH Extracellular

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    63996864..64035406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_546777.6 → XP_546777.4  paraplegin

    UniProtKB/TrEMBL
    A0A8C0JXB0, A0A8I3MG69
    Conserved Domains (2) summary
    TIGR01241
    Location:265 → 748
    FtsH_fam; ATP-dependent metalloprotease FtsH
    pfam06480
    Location:145 → 242
    FtsH_ext; FtsH Extracellular
Nucleotide Protein
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