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NPHP4 nephrocystin 4 [ Canis lupus familiaris (dog) ]

Gene ID: 489625, updated on 25-Jul-2026
Official Symbol
NPHP4provided by VGNC
Official Full Name
nephrocystin 4provided by VGNC
Primary source
VGNC:VGNC:43920
See related
Ensembl:ENSCAFG00845021358 RGD:12160370
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
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Try the new Transcripts and proteins table
See NPHP4 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
38
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (60022493..60152631, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (59830501..59946241, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (60303659..60419425, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (60035853..60151600, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (59902253..60018001, complement)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111095969 Neighboring gene uncharacterized LOC111095970 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 2 Neighboring gene chromodomain helicase DNA binding protein 5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Analysis of a deletion in the nephronophthisis 4 gene in different dog breeds. Palánová A, et al. Vet Ophthalmol, 2014 Jan. PMID 23998563
  2. A deletion in nephronophthisis 4 (NPHP4) is associated with recessive cone-rod dystrophy in standard wire-haired dachshund. Wiik AC, et al. Genome Res, 2008 Sep. PMID 18687878, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein localization to ciliary transition zone IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ciliary base IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ciliary transition zone IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in non-motile cilium IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
nephrocystin-4
Names
nephroretinin

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135788.1 → NP_001129260.1  nephrocystin-4

    See identical proteins and their annotated locations for NP_001129260.1

    Status: PROVISIONAL

    Source sequence(s)
    EU659993
    UniProtKB/TrEMBL
    A0A8C0QXY0, A0A8I3PGH6, B5LBI2
    Related
    ENSCAFP00845029561.1, ENSCAFT00845037727.1
    Conserved Domains (1) summary
    pfam15551
    Location:414 → 575
    DUF4656; Domain of unknown function (DUF4656)

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    60022493..60152631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038664189.1 → XP_038520117.1  nephrocystin-4 isoform X9

    UniProtKB/TrEMBL
    A0A8I3PGK0
    Conserved Domains (1) summary
    cd22239
    Location:112 → 1418
    NPHP4; Nephrocystin-4

  2. XM_038664183.1 → XP_038520111.1  nephrocystin-4 isoform X4

    UniProtKB/TrEMBL
    A0A8I3PGH6
    Conserved Domains (2) summary
    PRK12495
    Location:523 → 624
    PRK12495; hypothetical protein; Provisional
    cd22239
    Location:112 → 1478
    NPHP4; Nephrocystin-4

  3. XM_038664188.1 → XP_038520116.1  nephrocystin-4 isoform X8

    UniProtKB/TrEMBL
    A0A8I3PGH6
    Conserved Domains (2) summary
    PRK12495
    Location:467 → 568
    PRK12495; hypothetical protein; Provisional
    cd22239
    Location:56 → 1423
    NPHP4; Nephrocystin-4

  4. XM_038664184.1 → XP_038520112.1  nephrocystin-4 isoform X5

    UniProtKB/TrEMBL
    A0A8I3PGH6
    Conserved Domains (2) summary
    PRK12495
    Location:501 → 602
    PRK12495; hypothetical protein; Provisional
    cd22239
    Location:90 → 1457
    NPHP4; Nephrocystin-4

  5. XM_038664187.1 → XP_038520115.1  nephrocystin-4 isoform X7

    UniProtKB/TrEMBL
    A0A8I3PH47
    Conserved Domains (1) summary
    cd22239
    Location:112 → 1442
    NPHP4; Nephrocystin-4

  6. XM_038664181.1 → XP_038520109.1  nephrocystin-4 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PGH6
    Conserved Domains (2) summary
    PRK12495
    Location:523 → 623
    PRK12495; hypothetical protein; Provisional
    cd22239
    Location:112 → 1478
    NPHP4; Nephrocystin-4

  7. XM_038664182.1 → XP_038520110.1  nephrocystin-4 isoform X3

    UniProtKB/TrEMBL
    A0A8I3PGH6
    Conserved Domains (2) summary
    PRK12495
    Location:523 → 624
    PRK12495; hypothetical protein; Provisional
    cd22239
    Location:112 → 1478
    NPHP4; Nephrocystin-4

  8. XM_038664180.1 → XP_038520108.1  nephrocystin-4 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PGH6
    Conserved Domains (2) summary
    PRK12495
    Location:523 → 624
    PRK12495; hypothetical protein; Provisional
    cd22239
    Location:112 → 1479
    NPHP4; Nephrocystin-4

  9. XM_038664178.1 → XP_038520106.1  nephrocystin-4 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PGH6
    Conserved Domains (2) summary
    PRK12495
    Location:523 → 624
    PRK12495; hypothetical protein; Provisional
    cd22239
    Location:112 → 1479
    NPHP4; Nephrocystin-4

  10. XM_038664185.1 → XP_038520113.1  nephrocystin-4 isoform X5

    UniProtKB/TrEMBL
    A0A8I3PGH6
    Conserved Domains (2) summary
    PRK12495
    Location:501 → 602
    PRK12495; hypothetical protein; Provisional
    cd22239
    Location:90 → 1457
    NPHP4; Nephrocystin-4

  11. XM_038664186.1 → XP_038520114.1  nephrocystin-4 isoform X6

    UniProtKB/TrEMBL
    A0A8I3PGH6
    Conserved Domains (2) summary
    PRK12495
    Location:523 → 624
    PRK12495; hypothetical protein; Provisional
    cd22239
    Location:112 → 1479
    NPHP4; Nephrocystin-4

  12. XM_038664179.1 → XP_038520107.1  nephrocystin-4 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PGH6
    Conserved Domains (2) summary
    PRK12495
    Location:523 → 624
    PRK12495; hypothetical protein; Provisional
    cd22239
    Location:112 → 1479
    NPHP4; Nephrocystin-4

  13. XM_038664191.1 → XP_038520119.1  nephrocystin-4 isoform X10

    UniProtKB/TrEMBL
    A0A8I3PGH6
    Conserved Domains (2) summary
    PRK12495
    Location:523 → 624
    PRK12495; hypothetical protein; Provisional
    cd22239
    Location:112 → 1479
    NPHP4; Nephrocystin-4

  14. XM_038664193.1 → XP_038520121.1  nephrocystin-4 isoform X12

    UniProtKB/TrEMBL
    A0A8C0QXY0, A0A8I3PGH6
    Conserved Domains (2) summary
    PRK12495
    Location:523 → 624
    PRK12495; hypothetical protein; Provisional
    cd22239
    Location:112 → 1477
    NPHP4; Nephrocystin-4

  15. XM_038664194.1 → XP_038520122.1  nephrocystin-4 isoform X13

    UniProtKB/TrEMBL
    A0A8C0QXY0, A0A8I3PGH6
    Related
    ENSCAFP00845030535.1, ENSCAFT00845038985.1
    Conserved Domains (2) summary
    PRK12495
    Location:467 → 567
    PRK12495; hypothetical protein; Provisional
    cd22239
    Location:56 → 1421
    NPHP4; Nephrocystin-4

  16. XM_038664192.1 → XP_038520120.1  nephrocystin-4 isoform X11

    UniProtKB/TrEMBL
    A0A8C0QXY0, A0A8I3PGH6
    Conserved Domains (2) summary
    PRK12495
    Location:523 → 623
    PRK12495; hypothetical protein; Provisional
    cd22239
    Location:112 → 1477
    NPHP4; Nephrocystin-4

  17. XM_038664190.1 → XP_038520118.1  nephrocystin-4 isoform X10

    UniProtKB/TrEMBL
    A0A8I3PGH6
    Conserved Domains (2) summary
    PRK12495
    Location:523 → 624
    PRK12495; hypothetical protein; Provisional
    cd22239
    Location:112 → 1479
    NPHP4; Nephrocystin-4

  18. XM_038664196.1 → XP_038520124.1  nephrocystin-4 isoform X15

    UniProtKB/TrEMBL
    A0A8I3PAB2
    Conserved Domains (2) summary
    PRK12495
    Location:523 → 624
    PRK12495; hypothetical protein; Provisional
    cd22239
    Location:112 → 1246
    NPHP4; Nephrocystin-4

  19. XM_038664195.1 → XP_038520123.1  nephrocystin-4 isoform X14

    UniProtKB/TrEMBL
    A0A8I3PAB2
    Conserved Domains (2) summary
    PRK12495
    Location:523 → 624
    PRK12495; hypothetical protein; Provisional
    cd22239
    Location:112 → 1247
    NPHP4; Nephrocystin-4

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    60035853..60151600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    59902253..60018001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    60303659..60419425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    59830501..59946241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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