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CSF1R colony stimulating factor 1 receptor [ Canis lupus familiaris (dog) ]

Gene ID: 489188, updated on 25-Jul-2026
Official Symbol
CSF1Rprovided by VGNC
Official Full Name
colony stimulating factor 1 receptorprovided by VGNC
Primary source
VGNC:VGNC:39653
See related
Ensembl:ENSCAFG00845008395 RGD:12304144
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See CSF1R in Genome Data Viewer
Location:
chromosome: 4
Exon count:
21
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (59461238..59491183)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (58746695..58776657)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (59895615..59925571)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (59249977..59279943)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (59364574..59394530)

Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene caudal type homeobox 1 Neighboring gene platelet derived growth factor receptor beta Neighboring gene HMG-box containing 3 Neighboring gene tigger transposable element derived 6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. CSF-1R as an inhibitor of apoptosis and promoter of proliferation, migration and invasion of canine mammary cancer cells. Król M, et al. BMC Vet Res, 2013 Apr 5. PMID 23561040, Free PMC Article
  2. Immunohistochemical Expression of CCR2, CSF1R and MMP9 in Canine Inflammatory Mammary Carcinomas. Raposo TP, et al. Anticancer Res, 2016 Apr. PMID 27069163
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Immunohistochemical Expression of CCR2, CSF1R and MMP9 in Canine Inflammatory Mammary Carcinomas
    Title: Immunohistochemical Expression of CCR2, CSF1R and MMP9 in Canine Inflammatory Mammary Carcinomas.
  2. inhibitor of apoptosis and promoter of proliferation, migration and invasion of mammary cancer cells
    Title: CSF-1R as an inhibitor of apoptosis and promoter of proliferation, migration and invasion of canine mammary cancer cells.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables macrophage colony-stimulating factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of CSF1-CSF1R complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of signaling receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
macrophage colony-stimulating factor 1 receptor
Names
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog
XP_038329885.1
XP_038390977.1
XP_038455274.1
XP_038519585.1
XP_546306.2

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051808.1 Reference ROS_Cfam_1.0

    Range
    59461238..59491183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038663657.1 → XP_038519585.1  macrophage colony-stimulating factor 1 receptor

    UniProtKB/TrEMBL
    A0A8I3MXT5
    Related
    ENSCAFP00845011465.1, ENSCAFT00845014795.1
    Conserved Domains (5) summary
    smart00410
    Location:113 → 195
    IG_like; Immunoglobulin like
    pfam13927
    Location:399 → 486
    Ig_3; Immunoglobulin domain
    cd00096
    Location:203 → 208
    Ig; Ig strand A [structural motif]
    cl11960
    Location:203 → 295
    Ig; Immunoglobulin domain
    cl21453
    Location:540 → 912
    PKc_like; Protein Kinases, catalytic domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049264.1 Alternate UMICH_Zoey_3.1

    Range
    59249977..59279943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038473957.1 → XP_038329885.1  

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

    Range
    59364574..59394530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038599346.1 → XP_038455274.1  

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

    Range
    59895615..59925571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038535049.1 → XP_038390977.1  macrophage colony-stimulating factor 1 receptor

    UniProtKB/TrEMBL
    A0A8I3MXT5

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    58746695..58776657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_546306.7 → XP_546306.2  macrophage colony-stimulating factor 1 receptor

    UniProtKB/TrEMBL
    A0A8I3MXT5
    Conserved Domains (7) summary
    cd00096
    Location:415 → 496
    Ig; Immunoglobulin domain
    smart00409
    Location:405 → 493
    IG; Immunoglobulin
    smart00410
    Location:209 → 290
    IG_like; Immunoglobulin like
    pfam00047
    Location:209 → 293
    ig; Immunoglobulin domain
    pfam07714
    Location:579 → 908
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:299 → 398
    Ig; Immunoglobulin domain
    cl21453
    Location:540 → 912
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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