GPX3 glutathione peroxidase 3 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: GPX3provided by VGNC
Official Full Name: glutathione peroxidase 3provided by VGNC
Primary source: VGNC:VGNC:41463
See related: RGD:12371655
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	4	NC_051808.1 (58638793..58647136, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	4	NC_006586.4 (57952390..57960731, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	4	NC_049225.1 (59058428..59066768, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	4	NC_049264.1 (58456392..58464733, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	4	NC_049745.1 (58555078..58563407, complement)

Chromosome 4 - NC_051808.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables selenium binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: glutathione peroxidase 3

Names: glutathione peroxidase 3 (plasma)

NP_001157926.1

EC 1.11.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164454.1 → NP_001157926.1 glutathione peroxidase 3 precursor

Status: VALIDATED

Source sequence(s)

DN350586, DN374277, DN439024, DN873362, DN878031, DN904267

UniProtKB/TrEMBL

A0A8C0LIL1

Conserved Domains (1) summary

cd00340
Location:39 → 211

GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...