U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PFN3 profilin 3 [ Canis lupus familiaris (dog) ]

Gene ID: 489091, updated on 27-Jun-2026
Official Symbol
PFN3provided by VGNC
Official Full Name
profilin 3provided by VGNC
Primary source
VGNC:VGNC:44449
See related
Ensembl:ENSCAFG00845010383 RGD:12091459
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See PFN3 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
1
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (36325863..36326951)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (35927059..35928149)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (36846539..36847627)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (36151087..36152175)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (36337305..36338395)

Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene proline rich 7, synaptic Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene uncharacterized LOC111095525 Neighboring gene coagulation factor XII Neighboring gene solute carrier family 34 member 1 Neighboring gene regulator of G protein signaling 14

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of actin filament bundle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
profilin-3

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051808.1 Reference ROS_Cfam_1.0

    Range
    36325863..36326951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038663249.1 → XP_038519177.1  profilin-3

    UniProtKB/TrEMBL
    A0A8C0QZD8, A0A8I3N5I2
    Related
    ENSCAFP00845014268.1, ENSCAFT00845018285.1
    Conserved Domains (1) summary
    cd00148
    Location:3 → 136
    PROF; Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049264.1 Alternate UMICH_Zoey_3.1

    Range
    36151087..36152175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038473569.1 → XP_038329497.1  

    Conserved Domains (1) summary
    cd00148
    Location:3 → 136
    PROF; Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the ...

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

    Range
    36337305..36338395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038598946.1 → XP_038454874.1  

    Conserved Domains (1) summary
    cd00148
    Location:3 → 136
    PROF; Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the ...

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

    Range
    36846539..36847627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038534642.1 → XP_038390570.1  profilin-3

    UniProtKB/TrEMBL
    A0A8C0QZD8, A0A8I3N5I2
    Conserved Domains (1) summary
    cd00148
    Location:3 → 136
    PROF; Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    35927059..35928149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014112988.3 → XP_013968463.1  profilin-3

    UniProtKB/TrEMBL
    A0A8C0QZD8, A0A8I3N5I2
    Conserved Domains (1) summary
    cd00148
    Location:3 → 136
    PROF; Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials