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PDE8A phosphodiesterase 8A [ Canis lupus familiaris (dog) ]

Gene ID: 488752, updated on 18-Sep-2020

Summary

Official Symbol
PDE8Aprovided by VGNC
Official Full Name
phosphodiesterase 8Aprovided by VGNC
Primary source
VGNC:VGNC:44365
See related
Ensembl:ENSCAFG00000013011
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs

Genomic context

See PDE8A in Genome Data Viewer
Location:
chromosome: 3
Exon count:
22
Annotation release Status Assembly Chr Location
105 current CanFam3.1 (GCF_000002285.3) 3 NC_006585.3 (54278498..54367492)

Chromosome 3 - NC_006585.3Genomic Context describing neighboring genes Neighboring gene solute carrier family 28 member 1 Neighboring gene 60S ribosomal protein L17-like Neighboring gene ribosomal protein S17 Neighboring gene cytoplasmic polyadenylation element binding protein 1

Genomic regions, transcripts, and products

Genomic Sequence:
NC_006585.3 Chromosome 3 Reference CanFam3.1 Primary Assembly

Pathways from PubChem

General gene information

Homology

General protein information

Preferred Names
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
XP_005618439.1
XP_022272671.1
XP_022272672.1

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CanFam3.1 Primary Assembly

Genomic

  1. NC_006585.3 Reference CanFam3.1 Primary Assembly

    Range
    54278498..54367492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022416964.1XP_022272672.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3

    Related
    ENSCAFP00000058707.1, ENSCAFT00000083070.1
    Conserved Domains (3) summary
    COG0745
    Location:1097
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:457713
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:154252
    PAS_9; PAS domain
  2. XM_022416963.1XP_022272671.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1

    Conserved Domains (3) summary
    COG0745
    Location:1097
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    pfam00233
    Location:483739
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:154252
    PAS_9; PAS domain
  3. XM_005618382.3XP_005618439.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2

    UniProtKB/TrEMBL
    F1PB69
    Related
    ENSCAFP00000019209.4, ENSCAFT00000020695.5
    Conserved Domains (5) summary
    COG0745
    Location:1097
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    cd00130
    Location:158252
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:483735
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:154252
    PAS_9; PAS domain
    cl19078
    Location:1197
    REC; Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; ...
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