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NPY1R neuropeptide Y receptor Y1 [ Homo sapiens (human) ]

Gene ID: 4886, updated on 1-Jun-2020

Summary

Official Symbol
NPY1Rprovided by HGNC
Official Full Name
neuropeptide Y receptor Y1provided by HGNC
Primary source
HGNC:HGNC:7956
See related
Ensembl:ENSG00000164128 MIM:162641
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPYR; NPY1-R
Summary
This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
Expression
Biased expression in spleen (RPKM 33.6), fat (RPKM 10.5) and 9 other tissues See more
Orthologs

Genomic context

See NPY1R in Genome Data Viewer
Location:
4q32.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (163323962..163344832, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (164245116..164265984, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377517 Neighboring gene mitochondrial ribosomal protein S5 pseudogene Neighboring gene neuropeptide Y receptor Y5 Neighboring gene ribosomal protein L35a pseudogene 12 Neighboring gene transketolase like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
neuropeptide Y receptor activity TAS
Traceable Author Statement
more info
PubMed 
pancreatic polypeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide YY receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
feeding behavior IEA
Inferred from Electronic Annotation
more info
 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neuropeptide Y receptor type 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000909.6NP_000900.1  neuropeptide Y receptor type 1

    See identical proteins and their annotated locations for NP_000900.1

    Status: VALIDATED

    Source sequence(s)
    AC079238, BC036657
    Consensus CDS
    CCDS34089.1
    UniProtKB/Swiss-Prot
    P25929
    Related
    ENSP00000354652.2, ENST00000296533.3
    Conserved Domains (2) summary
    pfam00001
    Location:57320
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:52176
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    163323962..163344832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263031.4XP_005263088.1  neuropeptide Y receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_005263088.1

    UniProtKB/Swiss-Prot
    P25929
    Conserved Domains (2) summary
    pfam00001
    Location:57320
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:52176
    7tm_4; Olfactory receptor
  2. XM_011532010.3XP_011530312.1  neuropeptide Y receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_011530312.1

    UniProtKB/Swiss-Prot
    P25929
    Conserved Domains (2) summary
    pfam00001
    Location:57320
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:52176
    7tm_4; Olfactory receptor
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