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AOX4 aldehyde oxidase 4 [ Canis lupus familiaris (dog) ]

Gene ID: 488467, updated on 27-Jun-2026
Official Symbol
AOX4provided by VGNC
Official Full Name
aldehyde oxidase 4provided by VGNC
Primary source
VGNC:VGNC:109266
See related
Ensembl:ENSCAFG00845028797 RGD:12091412
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
AOH2
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Try the new Transcripts and proteins table
See AOX4 in Genome Data Viewer
Location:
chromosome: 37
Exon count:
36
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 37 NC_051841.1 (9743096..9807466)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 37 NC_006619.4 (10723944..10786765)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 37 NC_049258.1 (9696603..9759976)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 37 NC_049297.1 (9724911..9788299)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 37 NC_049778.1 (9703544..9766613)

Chromosome 37 - NC_051841.1Genomic Context describing neighboring genes Neighboring gene translationally-controlled tumor protein-like Neighboring gene uncharacterized LOC100855711 Neighboring gene methylsterol monooxygenase 1-like Neighboring gene aldehyde oxidase 2 Neighboring gene uncharacterized LOC102154768

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Avian and canine aldehyde oxidases. Novel insights into the biology and evolution of molybdo-flavoenzymes. Terao M, et al. J Biol Chem, 2006 Jul 14. PMID 16672219
  2. Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression. Kurosaki M, et al. Cell Mol Life Sci, 2013 May. PMID 23263164, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
aldehyde oxidase 4
Names
aldehyde oxidase 2
NP_001038214.1
XP_038303234.1
XP_038303235.1
XP_038303236.1
XP_038303238.1
XP_038303239.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044749.1 → NP_001038214.1  aldehyde oxidase 4

    See identical proteins and their annotated locations for NP_001038214.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ150104
    UniProtKB/TrEMBL
    A0A8I3Q6L9, Q2QB48
    Related
    ENSCAFP00845040100.1, ENSCAFT00845051140.1
    Conserved Domains (6) summary
    TIGR02969
    Location:9 → 1334
    mam_aldehyde_ox; aldehyde oxidase
    smart01008
    Location:595 → 698
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    pfam00941
    Location:240 → 420
    FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
    pfam01799
    Location:91 → 162
    Fer2_2; [2Fe-2S] binding domain
    pfam02738
    Location:708 → 1242
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
    pfam03450
    Location:430 → 531
    CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051841.1 Reference ROS_Cfam_1.0

    Range
    9743096..9807466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038447306.1 → XP_038303234.1  aldehyde oxidase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I3Q6L9
    Conserved Domains (1) summary
    TIGR02969
    Location:10 → 1335
    mam_aldehyde_ox; aldehyde oxidase

  2. XM_038447308.1 → XP_038303236.1  aldehyde oxidase 4 isoform X3

    UniProtKB/TrEMBL
    A0A8I3Q6L9
    Conserved Domains (1) summary
    TIGR02969
    Location:10 → 1306
    mam_aldehyde_ox; aldehyde oxidase

  3. XM_038447310.1 → XP_038303238.1  aldehyde oxidase 4 isoform X4

    UniProtKB/TrEMBL
    M1ZMR8
    Conserved Domains (1) summary
    TIGR02969
    Location:25 → 1288
    mam_aldehyde_ox; aldehyde oxidase

  4. XM_038447307.1 → XP_038303235.1  aldehyde oxidase 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I3Q6L9
    Conserved Domains (1) summary
    TIGR02969
    Location:4 → 1320
    mam_aldehyde_ox; aldehyde oxidase

  5. XM_038447311.1 → XP_038303239.1  aldehyde oxidase 4 isoform X5

    UniProtKB/TrEMBL
    M1ZMR8
    Conserved Domains (1) summary
    TIGR02969
    Location:2 → 1159
    mam_aldehyde_ox; aldehyde oxidase

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049297.1 Alternate UMICH_Zoey_3.1

    Range
    9724911..9788299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049778.1 Alternate UNSW_CanFamBas_1.0

    Range
    9703544..9766613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049258.1 Alternate UU_Cfam_GSD_1.0

    Range
    9696603..9759976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006619.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    10723944..10786765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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