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RAPGEF4 Rap guanine nucleotide exchange factor 4 [ Canis lupus familiaris (dog) ]

Gene ID: 488402, updated on 27-Jun-2026
Official Symbol
RAPGEF4provided by VGNC
Official Full Name
Rap guanine nucleotide exchange factor 4provided by VGNC
Primary source
VGNC:VGNC:53103
See related
Ensembl:ENSCAFG00845028929 RGD:12272008
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See RAPGEF4 in Genome Data Viewer
Location:
chromosome: 36
Exon count:
37
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 36 NC_051840.1 (17166818..17450241)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 36 NC_006618.4 (17044798..17327450)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 36 NC_049257.1 (17349948..17632781)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 36 NC_049296.1 (17247410..17530838)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 36 NC_049777.1 (17246048..17529604)

Chromosome 36 - NC_051840.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102153619 Neighboring gene uncharacterized LOC111094204 Neighboring gene pyruvate dehydrogenase kinase 1 Neighboring gene uncharacterized LOC119867831 Neighboring gene uncharacterized LOC102153088 Neighboring gene mitogen-activated protein kinase kinase kinase 20 Neighboring gene uncharacterized LOC102154031 Neighboring gene uncharacterized LOC111094212

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
rap guanine nucleotide exchange factor 4

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051840.1 Reference ROS_Cfam_1.0

    Range
    17166818..17450241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038447070.1 → XP_038302998.1  rap guanine nucleotide exchange factor 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0QVK1, A0A8I3PZ28
    Related
    ENSCAFP00845040385.1, ENSCAFT00845051471.1
    Conserved Domains (4) summary
    smart00147
    Location:768 → 1009
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43 → 158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:206 → 334
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:499 → 605
    RasGEF_N; RasGEF N-terminal motif

  2. XM_038447071.1 → XP_038302999.1  rap guanine nucleotide exchange factor 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0QVK1
    Conserved Domains (4) summary
    smart00147
    Location:750 → 991
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43 → 158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:188 → 316
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:481 → 587
    RasGEF_N; RasGEF N-terminal motif

  3. XM_038447072.1 → XP_038303000.1  rap guanine nucleotide exchange factor 4 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:638 → 879
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:226 → 337
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:76 → 204
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:369 → 475
    RasGEF_N; RasGEF N-terminal motif

  4. XM_038447079.1 → XP_038303007.1  rap guanine nucleotide exchange factor 4 isoform X8

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:615 → 856
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:203 → 314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:53 → 181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:346 → 452
    RasGEF_N; RasGEF N-terminal motif

  5. XM_038447074.1 → XP_038303002.1  rap guanine nucleotide exchange factor 4 isoform X5

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:630 → 871
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:218 → 329
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:68 → 196
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:361 → 467
    RasGEF_N; RasGEF N-terminal motif

  6. XM_038447075.1 → XP_038303003.1  rap guanine nucleotide exchange factor 4 isoform X6

    UniProtKB/TrEMBL
    A0A8C0JV71, A0A8I3QRR0
    Related
    ENSCAFP00845040428.1, ENSCAFT00845051524.1
    Conserved Domains (4) summary
    smart00147
    Location:624 → 865
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:212 → 323
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:62 → 190
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:355 → 461
    RasGEF_N; RasGEF N-terminal motif

  7. XM_038447077.1 → XP_038303005.1  rap guanine nucleotide exchange factor 4 isoform X8

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:615 → 856
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:203 → 314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:53 → 181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:346 → 452
    RasGEF_N; RasGEF N-terminal motif

  8. XM_038447081.1 → XP_038303009.1  rap guanine nucleotide exchange factor 4 isoform X10

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:597 → 838
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:185 → 296
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:35 → 163
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:328 → 434
    RasGEF_N; RasGEF N-terminal motif

  9. XM_038447078.1 → XP_038303006.1  rap guanine nucleotide exchange factor 4 isoform X8

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:615 → 856
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:203 → 314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:53 → 181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:346 → 452
    RasGEF_N; RasGEF N-terminal motif

  10. XM_038447080.1 → XP_038303008.1  rap guanine nucleotide exchange factor 4 isoform X9

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:600 → 841
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:188 → 299
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:38 → 166
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:331 → 437
    RasGEF_N; RasGEF N-terminal motif

  11. XM_038447073.1 → XP_038303001.1  rap guanine nucleotide exchange factor 4 isoform X4

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:631 → 872
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:219 → 330
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:69 → 197
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:362 → 468
    RasGEF_N; RasGEF N-terminal motif

  12. XM_038447076.1 → XP_038303004.1  rap guanine nucleotide exchange factor 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:604 → 845
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:192 → 303
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:42 → 170
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:335 → 441
    RasGEF_N; RasGEF N-terminal motif

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049296.1 Alternate UMICH_Zoey_3.1

    Range
    17247410..17530838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038521150.1 → XP_038377078.1  

    Conserved Domains (4) summary
    smart00147
    Location:768 → 1009
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43 → 158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:206 → 334
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:499 → 605
    RasGEF_N; RasGEF N-terminal motif

  2. XM_038521151.1 → XP_038377079.1  

    Conserved Domains (4) summary
    smart00147
    Location:750 → 991
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43 → 158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:188 → 316
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:481 → 587
    RasGEF_N; RasGEF N-terminal motif

  3. XM_038521152.1 → XP_038377080.1  

    Conserved Domains (4) summary
    smart00147
    Location:638 → 879
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:226 → 337
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:76 → 204
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:369 → 475
    RasGEF_N; RasGEF N-terminal motif

  4. XM_038521160.1 → XP_038377088.1  

    Conserved Domains (4) summary
    smart00147
    Location:615 → 856
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:203 → 314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:53 → 181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:346 → 452
    RasGEF_N; RasGEF N-terminal motif

  5. XM_038521153.1 → XP_038377081.1  

    Conserved Domains (4) summary
    smart00147
    Location:630 → 871
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:218 → 329
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:68 → 196
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:361 → 467
    RasGEF_N; RasGEF N-terminal motif

  6. XM_038521155.1 → XP_038377083.1  

    Conserved Domains (4) summary
    smart00147
    Location:624 → 865
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:212 → 323
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:62 → 190
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:355 → 461
    RasGEF_N; RasGEF N-terminal motif

  7. XM_038521157.1 → XP_038377085.1  

    Conserved Domains (4) summary
    smart00147
    Location:615 → 856
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:203 → 314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:53 → 181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:346 → 452
    RasGEF_N; RasGEF N-terminal motif

  8. XM_038521162.1 → XP_038377090.1  

    Conserved Domains (4) summary
    smart00147
    Location:597 → 838
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:185 → 296
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:35 → 163
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:328 → 434
    RasGEF_N; RasGEF N-terminal motif

  9. XM_038521158.1 → XP_038377086.1  

    Conserved Domains (4) summary
    smart00147
    Location:615 → 856
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:203 → 314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:53 → 181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:346 → 452
    RasGEF_N; RasGEF N-terminal motif

  10. XM_038521161.1 → XP_038377089.1  

    Conserved Domains (4) summary
    smart00147
    Location:600 → 841
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:188 → 299
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:38 → 166
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:331 → 437
    RasGEF_N; RasGEF N-terminal motif

  11. XM_038521159.1 → XP_038377087.1  

    Conserved Domains (4) summary
    smart00147
    Location:615 → 856
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:203 → 314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:53 → 181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:346 → 452
    RasGEF_N; RasGEF N-terminal motif

  12. XM_038521156.1 → XP_038377084.1  

    Conserved Domains (4) summary
    smart00147
    Location:604 → 845
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:192 → 303
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:42 → 170
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:335 → 441
    RasGEF_N; RasGEF N-terminal motif

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049777.1 Alternate UNSW_CanFamBas_1.0

    Range
    17246048..17529604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038649265.1 → XP_038505193.1  

    Conserved Domains (4) summary
    smart00147
    Location:768 → 1009
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43 → 158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:206 → 334
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:499 → 605
    RasGEF_N; RasGEF N-terminal motif

  2. XM_038649266.1 → XP_038505194.1  

    Conserved Domains (4) summary
    smart00147
    Location:750 → 991
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43 → 158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:188 → 316
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:481 → 587
    RasGEF_N; RasGEF N-terminal motif

  3. XM_038649267.1 → XP_038505195.1  

    Conserved Domains (4) summary
    smart00147
    Location:638 → 879
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:226 → 337
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:76 → 204
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:369 → 475
    RasGEF_N; RasGEF N-terminal motif

  4. XM_038649275.1 → XP_038505203.1  

    Conserved Domains (4) summary
    smart00147
    Location:615 → 856
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:203 → 314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:53 → 181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:346 → 452
    RasGEF_N; RasGEF N-terminal motif

  5. XM_038649270.1 → XP_038505198.1  

    Conserved Domains (4) summary
    smart00147
    Location:630 → 871
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:218 → 329
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:68 → 196
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:361 → 467
    RasGEF_N; RasGEF N-terminal motif

  6. XM_038649271.1 → XP_038505199.1  

    Conserved Domains (4) summary
    smart00147
    Location:624 → 865
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:212 → 323
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:62 → 190
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:355 → 461
    RasGEF_N; RasGEF N-terminal motif

  7. XM_038649273.1 → XP_038505201.1  

    Conserved Domains (4) summary
    smart00147
    Location:615 → 856
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:203 → 314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:53 → 181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:346 → 452
    RasGEF_N; RasGEF N-terminal motif

  8. XM_038649277.1 → XP_038505205.1  

    Conserved Domains (4) summary
    smart00147
    Location:597 → 838
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:185 → 296
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:35 → 163
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:328 → 434
    RasGEF_N; RasGEF N-terminal motif

  9. XM_038649274.1 → XP_038505202.1  

    Conserved Domains (4) summary
    smart00147
    Location:615 → 856
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:203 → 314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:53 → 181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:346 → 452
    RasGEF_N; RasGEF N-terminal motif

  10. XM_038649276.1 → XP_038505204.1  

    Conserved Domains (4) summary
    smart00147
    Location:600 → 841
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:188 → 299
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:38 → 166
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:331 → 437
    RasGEF_N; RasGEF N-terminal motif

  11. XM_038649269.1 → XP_038505197.1  

    Conserved Domains (4) summary
    smart00147
    Location:631 → 872
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:219 → 330
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:69 → 197
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:362 → 468
    RasGEF_N; RasGEF N-terminal motif

  12. XM_038649272.1 → XP_038505200.1  

    Conserved Domains (4) summary
    smart00147
    Location:604 → 845
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:192 → 303
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:42 → 170
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:335 → 441
    RasGEF_N; RasGEF N-terminal motif

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049257.1 Alternate UU_Cfam_GSD_1.0

    Range
    17349948..17632781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038584850.1 → XP_038440778.1  rap guanine nucleotide exchange factor 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0QVK1, A0A8I3PZ28
    Conserved Domains (4) summary
    smart00147
    Location:768 → 1009
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43 → 158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:206 → 334
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:499 → 605
    RasGEF_N; RasGEF N-terminal motif

  2. XM_038584851.1 → XP_038440779.1  rap guanine nucleotide exchange factor 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0QVK1
    Conserved Domains (4) summary
    smart00147
    Location:750 → 991
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43 → 158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:188 → 316
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:481 → 587
    RasGEF_N; RasGEF N-terminal motif

  3. XM_038584852.1 → XP_038440780.1  rap guanine nucleotide exchange factor 4 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:638 → 879
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:226 → 337
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:76 → 204
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:369 → 475
    RasGEF_N; RasGEF N-terminal motif

  4. XM_038584859.1 → XP_038440787.1  rap guanine nucleotide exchange factor 4 isoform X8

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:615 → 856
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:203 → 314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:53 → 181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:346 → 452
    RasGEF_N; RasGEF N-terminal motif

  5. XM_038584854.1 → XP_038440782.1  rap guanine nucleotide exchange factor 4 isoform X5

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:630 → 871
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:218 → 329
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:68 → 196
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:361 → 467
    RasGEF_N; RasGEF N-terminal motif

  6. XM_038584855.1 → XP_038440783.1  rap guanine nucleotide exchange factor 4 isoform X6

    UniProtKB/TrEMBL
    A0A8C0JV71, A0A8I3QRR0
    Conserved Domains (4) summary
    smart00147
    Location:624 → 865
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:212 → 323
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:62 → 190
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:355 → 461
    RasGEF_N; RasGEF N-terminal motif

  7. XM_038584857.1 → XP_038440785.1  rap guanine nucleotide exchange factor 4 isoform X8

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:615 → 856
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:203 → 314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:53 → 181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:346 → 452
    RasGEF_N; RasGEF N-terminal motif

  8. XM_038584861.1 → XP_038440789.1  rap guanine nucleotide exchange factor 4 isoform X10

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:597 → 838
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:185 → 296
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:35 → 163
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:328 → 434
    RasGEF_N; RasGEF N-terminal motif

  9. XM_038584858.1 → XP_038440786.1  rap guanine nucleotide exchange factor 4 isoform X8

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:615 → 856
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:203 → 314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:53 → 181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:346 → 452
    RasGEF_N; RasGEF N-terminal motif

  10. XM_038584860.1 → XP_038440788.1  rap guanine nucleotide exchange factor 4 isoform X9

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:600 → 841
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:188 → 299
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:38 → 166
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:331 → 437
    RasGEF_N; RasGEF N-terminal motif

  11. XM_038584853.1 → XP_038440781.1  rap guanine nucleotide exchange factor 4 isoform X4

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:631 → 872
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:219 → 330
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:69 → 197
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:362 → 468
    RasGEF_N; RasGEF N-terminal motif

  12. XM_038584856.1 → XP_038440784.1  rap guanine nucleotide exchange factor 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:604 → 845
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:192 → 303
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:42 → 170
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:335 → 441
    RasGEF_N; RasGEF N-terminal motif

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006618.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    17044798..17327450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038463301.1 → XP_038319229.1  rap guanine nucleotide exchange factor 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0QVK1, A0A8I3PZ28
    Conserved Domains (4) summary
    smart00147
    Location:768 → 1009
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43 → 158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:206 → 334
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:499 → 605
    RasGEF_N; RasGEF N-terminal motif

  2. XM_038463302.1 → XP_038319230.1  rap guanine nucleotide exchange factor 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0QVK1
    Conserved Domains (4) summary
    smart00147
    Location:750 → 991
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:43 → 158
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:188 → 316
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:481 → 587
    RasGEF_N; RasGEF N-terminal motif

  3. XM_038463303.1 → XP_038319231.1  rap guanine nucleotide exchange factor 4 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:638 → 879
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:226 → 337
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:76 → 204
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:369 → 475
    RasGEF_N; RasGEF N-terminal motif

  4. XM_014110687.3 → XP_013966162.1  rap guanine nucleotide exchange factor 4 isoform X8

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:615 → 856
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:203 → 314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:53 → 181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:346 → 452
    RasGEF_N; RasGEF N-terminal motif

  5. XM_038463304.1 → XP_038319232.1  rap guanine nucleotide exchange factor 4 isoform X5

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:630 → 871
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:218 → 329
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:68 → 196
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:361 → 467
    RasGEF_N; RasGEF N-terminal motif

  6. XM_038463305.1 → XP_038319233.1  rap guanine nucleotide exchange factor 4 isoform X6

    UniProtKB/TrEMBL
    A0A8C0JV71, A0A8I3QRR0
    Conserved Domains (4) summary
    smart00147
    Location:624 → 865
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:212 → 323
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:62 → 190
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:355 → 461
    RasGEF_N; RasGEF N-terminal motif

  7. XM_005640318.4 → XP_005640375.1  rap guanine nucleotide exchange factor 4 isoform X8

    See identical proteins and their annotated locations for XP_005640375.1

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:615 → 856
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:203 → 314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:53 → 181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:346 → 452
    RasGEF_N; RasGEF N-terminal motif

  8. XM_022414722.2 → XP_022270430.1  rap guanine nucleotide exchange factor 4 isoform X10

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:597 → 838
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:185 → 296
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:35 → 163
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:328 → 434
    RasGEF_N; RasGEF N-terminal motif

  9. XM_022414721.2 → XP_022270429.1  rap guanine nucleotide exchange factor 4 isoform X8

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:615 → 856
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:203 → 314
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:53 → 181
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:346 → 452
    RasGEF_N; RasGEF N-terminal motif

  10. XM_038463307.1 → XP_038319235.1  rap guanine nucleotide exchange factor 4 isoform X9

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:600 → 841
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:188 → 299
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:38 → 166
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:331 → 437
    RasGEF_N; RasGEF N-terminal motif

  11. XM_022414719.2 → XP_022270427.2  rap guanine nucleotide exchange factor 4 isoform X4

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:631 → 872
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:219 → 330
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:69 → 197
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:362 → 468
    RasGEF_N; RasGEF N-terminal motif

  12. XM_038463306.1 → XP_038319234.1  rap guanine nucleotide exchange factor 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C0JV71
    Conserved Domains (4) summary
    smart00147
    Location:604 → 845
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00038
    Location:192 → 303
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd04437
    Location:42 → 170
    DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    pfam00618
    Location:335 → 441
    RasGEF_N; RasGEF N-terminal motif
Nucleotide Protein
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