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NPTX1 neuronal pentraxin 1 [ Homo sapiens (human) ]

Gene ID: 4884, updated on 5-Mar-2024

Summary

Official Symbol
NPTX1provided by HGNC
Official Full Name
neuronal pentraxin 1provided by HGNC
Primary source
HGNC:HGNC:7952
See related
Ensembl:ENSG00000171246 MIM:602367; AllianceGenome:HGNC:7952
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NP1; SCA50
Summary
NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 51.6) and adrenal (RPKM 2.1) See more
Orthologs
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Genomic context

See NPTX1 in Genome Data Viewer
Location:
17q25.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (80466834..80476607, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (81368723..81378497, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (78440634..78450407, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 213 Neighboring gene RNF213 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:78345568-78346767 Neighboring gene MPRA-validated peak3024 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78354122-78354622 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:78359110-78360309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78369069-78369570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78371216-78371723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78371724-78372230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12935 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78398753-78399254 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78399255-78399754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78415272-78415938 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78419431-78420213 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78428217-78429046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12936 Neighboring gene Sharpr-MPRA regulatory region 4093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78441725-78442449 Neighboring gene microRNA 4730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78448861-78449394 Neighboring gene endonuclease V Neighboring gene Sharpr-MPRA regulatory region 3125 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78467323-78467823 Neighboring gene Sharpr-MPRA regulatory region 6979 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:78500540-78501513 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:78509630-78510257 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78518332-78519158 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:78519159-78519985 Neighboring gene MPRA-validated peak3025 silencer Neighboring gene uncharacterized LOC105371922 Neighboring gene Sharpr-MPRA regulatory region 3542 Neighboring gene ribosomal protein L32 pseudogene 31 Neighboring gene regulatory associated protein of MTOR complex 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC105123, DKFZp686J2446

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in synaptic cleft IEA
Inferred from Electronic Annotation
more info
 
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neuronal pentraxin-1
Names
NP-I
neuronal pentraxin I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002522.4NP_002513.2  neuronal pentraxin-1 precursor

    See identical proteins and their annotated locations for NP_002513.2

    Status: REVIEWED

    Source sequence(s)
    AC120024, AK127335, DA188847
    Consensus CDS
    CCDS32762.1
    UniProtKB/Swiss-Prot
    B3KXH3, Q15818, Q5FWE6
    Related
    ENSP00000307549.4, ENST00000306773.5
    Conserved Domains (1) summary
    smart00159
    Location:222428
    PTX; Pentraxin / C-reactive protein / pentaxin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    80466834..80476607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    81368723..81378497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)